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A note on the effects of antimalarial drugs on the sporogonous cycle of Plasmodium cynomolgi in Anopheles stephensi*

Published online by Cambridge University Press:  06 April 2009

Levon A. Terzian
Levon A. Terzian
Affiliation:
Naval Medical Research Institute, Bethesda, Maryland 20014
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Extract

It has been shown that in common with other malarial species the drug response in the sporogonous cycle of Plasmodium cynomolgi parallels in a special way the drug response in the schizogonous cycle. Thus, prophylactic drugs produce deteriorating changes in the oocysts while curative drugs have a destructive effect on the sporozoites. A comparison of the effects of prophylactic drugs on the sporogonous and schizogonous cycles of the four malarial species studied thus far suggests the presence of more than one pre-erythrocytic developmental stage in the schizogonous cycles of P. vivax and P. cynomolgi following the initial invasion by the sporozoite.

Type
Research Article
Information
Parasitology , Volume 61 , Issue 2 , October 1970 , pp. 191 - 194
Copyright
Copyright © Cambridge University Press 1970

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References

REFERENCES

Covell, G., Coatney, G. R., Field, J. W. & Singh, J. (1955). Chemotherapy of Malaria. Geneva; World Health Organization.Google Scholar
Terzian, L. A. (1947). A method for screening antimalarial compounds in the mosquito host. Science 106, 449–50.Google Scholar
Terzian, L. A. & Weathersby, A. B. (1949). The action of antimalarial drugs in mosquitoes infected with Plasmodium falciparum. American Journal of Tropical Medicine 29, 19–22.Google Scholar
Terzian, L. A., Stahler, N. & Weathersby, A. B. (1949). The action of antimalarial drugs in mosquitoes infected with Plasmodium gallinaceum. Journal of Infectious Diseases 84, 47–55.Google Scholar
Terzian, L. A., Stahler, N. & Dawkins, A. T. (1968). The sporogonous cycle of Plasmodium vivax in Anopheles mosquitoes as a system for evaluating the prophylactic and curative capabilities of potential antimalarial compounds. Experimental Parasitology 23, 56–66.Google Scholar
Terzian, L. A., Stahler, N. & Dawkins, A. T. (1970). Differences in drug response of the sporogonous cycles of three strains of Plasmodium falciparum in Anopheles stephensi. (In the Press.)Google Scholar
Terzian, L. A., Ward, P. A. & Stahler, N. (1951). A new criterion for the selection of compounds for curative activity in Plasmodium vivax malaria. American Journal of Tropical Medicine 31, 692–7.Google Scholar