Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-10T07:44:45.781Z Has data issue: false hasContentIssue false
  • English
  • Français

Portal shunting and resistance to Schistosoma mansoni in 129 strain mice

Published online by Cambridge University Press:  06 April 2009

P. S. Coulson  and
R. A. Wilson
P. S. Coulson
Affiliation:
Department of Biology, University of York, York Y01 5DD
R. A. Wilson
Affiliation:
Department of Biology, University of York, York Y01 5DD
Get access Rights & Permissions [Opens in a new window]

Summary

The integrity of the hepatic portal vasculature was examined, relative to the resistance to Schistosoma mansoni observed in 68°0 of 129/Ola mice. The passage of microspheres to the lungs, following their injection via the superior mesenteric vein, indicated the presence of shunts in the majority of both naive and infected mice. There was a negative association between shunting of microspheres to the lungs and paucity of liver worms at 28/35 days post-infection. Schistosomula accumulated in the livers of resistant mice at a slower rate than in susceptible animals, and after day 21 relocated to the lungs. Many lung schistosomula injected via the superior mesenteric passed immediately to the lungs; the shunts thus greatly reduce the probability of trapping in the liver. Some parasites migrated back from the lungs, successfully lodged in the liver and began to feed on blood. Latex infusion demonstrated the location of large intrahepatic connections between the portal and hepatic veins. We suggest that as these liver worms grow, migrating upstream into progressively larger vessels, they reach the connections, pass out of the hepatic portal system, and relocate to the lungs. The presence of the natural shunts thus accounts for the resistant status of the mice.

Keywords

Schistosoma mansoni129 strain micemicrospheresportacaval shunting.
Type
Research Article
Information
Parasitology , Volume 99 , Issue 3 , December 1989 , pp. 383 - 389
Copyright
Copyright © Cambridge University Press 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Davern, K. M., Tiu, W. U., Morahan, G., Wright, M. D., Garcia, E. G. & Mitchell, C. F. (1987). Responses in mice to Sj26, a glutathione S-transferase of Schistosoma japonicum worms. Immunology and Cell Biology 65, 473–82.CrossRefGoogle ScholarPubMed
Garcia, E. G., Tiu, W. U. & Mitchell, G. F. (1983). Innate resistance to Schistosoma japonicum in a proportion of 129/J mice. Journal of Parasitology 69, 613–15.CrossRefGoogle Scholar
Mangold, B. L., Dean, D. A., Coulson, P. S. & Wilson, R. A. (1986). Site requirements and kinetics of immunedependent elimination of intravascularly administered lung stage schistosomula in mice immunized with highly irradiated cercariae of Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 35, 332–44.CrossRefGoogle ScholarPubMed
Mchugh, S. M., Coulson, P. S. & Wilson, R. A. (1987). Pathologically induced alterations in the dimensions of the hepatic portal vasculature of mice infected with Schistosoma mansoni. Parasitology 94, 69–80.CrossRefGoogle ScholarPubMed
Medeiros, M. V.M. J. & Andrade, Z. A. (1986). The importance of collateral portal veins for resistance to schistosomiasis in mice. Brazilian Journal of Medical and Biological Research 19, 85–8.Google ScholarPubMed
Mitchell, G. F., Cruise, K. M., Garcia, E. G. & Tiu, W. U. (1984). Anti-worm antibody specificities in 129/J mice resistant to infection with Schistosoma japonicum. Journal of Parasitology 70, 983–5.CrossRefGoogle ScholarPubMed
Mitchell, G. F., Beall, J. A., Cruise, K. M., Tiu, W. U. & Garcia, E. G. (1985). Antibody responses to the antigen Sj26 of Schistosoma japonicum worms that is recognised by genetically resistant 129/J mice. Parasite Immunology 7, 165–78.CrossRefGoogle Scholar
Smith, D. B., Davern, K. M., Board, P. G., Tiu, W. U., Garcia, E. G. & Mitchell, G. F. (1986). Mr 26000 antigen of Schistosoma japonicum recognised by resistant WEHI 129/J mice is a parasite glutathione S-transferase. Proceedings of the National Academy of Sciences, USA 83, 8703–7.CrossRefGoogle Scholar
Smithers, S. R. & Terry, R. J. (1965). Infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Tiu, W. U., Ehl, A., Walker, J. C., Garcia, E. G., Smith, D. B. & Mitchell, G. F. (1986). Resistance of 129/J mice to Schistosoma mansoni infection. Australian Journal of Experimental Biology and Medical Science 64, 345–9.CrossRefGoogle ScholarPubMed
Wheater, P. R. & Wilson, R. A. (1979). Schistosovta mansoni: a histological study of migration in the laboratory mouse. Parasitology 75, 49–62.CrossRefGoogle Scholar
Wilson, R. A., Coulson, P. S. & Mchugh, S. M. (1983). A significant part of the ‘concomitant immunity’ of mice to Schistosoma mansoni is the consequence of a leaky hepatic portal system, not immune killing. Parasite Immunology 5, 595–601.CrossRefGoogle Scholar
Wilson, R. A. & Coulson, P. S. (1986). Schistosoma mansoni: dynamics of migration through the vascular system of the mouse. Parasitology 92, 83–100.CrossRefGoogle ScholarPubMed
Wilson, R. A., Coulson, P. S. & Dixon, B. (1986). Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae, and normal mice: an attempt to identify the timing and site of parasite death. Parasitology 92, 101–16.CrossRefGoogle ScholarPubMed
Wilson, R. A. (1987). Cercariae to liver worms: development and migration in the mammalian host.In The Biology of Schistosomes (ed. Rollinson, D. & Simpson, A. J. G.)., London: Academic Press. pp. 115–46.Google Scholar
Wright, M. D., Tiu, W. U., Wood, S. M., Walker, J. C., Garcia, E. G. & Mitchell, G. F. (1988). Schistosoma mansoni and S. japonicum worm numbers in 129/J mice of two types and dominance of susceptibility in F1 hybrids. Journal of Parasitology 74, 618–22.CrossRefGoogle ScholarPubMed