Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-13T09:43:12.320Z Has data issue: false hasContentIssue false
  • English
  • Français

The potential of vervet monkeys (Cercopithecus aethiops) and baboons (Papio anubis) as models for the study of the immunology of Echinococcus granulosus infections

Published online by Cambridge University Press:  06 April 2009

M. T. Rogan ,
I. Marshall ,
G. D. F. Reid ,
C. N. L. Macpherson  and
P. S. Craig
M. T. Rogan
Affiliation:
Department of Biological Sciences, University of Salford, Salford M5 4WT, UK
I. Marshall
Affiliation:
Division of Biomedical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
G. D. F. Reid
Affiliation:
Institute of Primate Research, Nairobi, Kenya
C. N. L. Macpherson
Affiliation:
Department of Veterinary Parasitology, University of the West Indies, Trinidad
P. S. Craig
Affiliation:
Department of Biological Sciences, University of Salford, Salford M5 4WT, UK
Get access Rights & Permissions [Opens in a new window]

Summary

Nine vervet monkeys and nine baboons were infected with eggs of Echinococcus granulosus per as. Six of the vervets and one of the baboons possessed hydatid cysts at autopsy, 15–28 months post-infection. The sequential IgG response to hydatid fluid and protoscolex antigens showed considerable inter-animal variation. Infected vervets and baboons became seropositive after an average of 8 months post-infection. Considerable fluctuation in the IgG response was observed, particularly to the hydatid fluid antigen which, in humans, may contribute to the existence of a significant proportion of seronegative individuals. Vervets, in particular, may be useful to study immunological events associated with exposure, development and resolution of hydatid disease in outbred human populations.

Keywords

vervet monkeybaboonEchinococcus granulosusprotoscolex antigenhydatid fluid antigen
Type
Research Article
Information
Parasitology , Volume 106 , Issue 5 , June 1993 , pp. 511 - 517
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Ali-Kahn, Z. & Siboo, R. (1980). Pathogenesis and host response in subcutaneous alveolar hydatidosis. I. Histogenesis of alveolar cyst and a quantitative analysis of the inflammatory infiltrates. Zeitschrift für Parasitenkunde 62, 241–54.CrossRefGoogle Scholar
Baron, R. W. & Tanner, C. E. (1976). The effect of immunosuppression on secondary Echinococcus multilocularis infections in mice. International Journal for Parasitology 6, 37–42.CrossRefGoogle ScholarPubMed
Bchir, A., Larouze, B., Soltani, M., Hamdi, A., Bouhaouala, H., Ducic, S., Bouden, L., Ganouni, A., Achour, H., Gaudebout, C, Rousset, J. J. & Jemmali, M. (1991). Echotomographic and serological population-based study of hydatidosis in Central Tunisia. Acta Tropica 49, 149–53.CrossRefGoogle ScholarPubMed
Beardsell, P. L. & Howell, M. J. (1984). Killing of Taenia hydatigena oncospheres by sheep neutrophils. Zeitschrift für Parasitenkunde 70, 337–44.CrossRefGoogle ScholarPubMed
Boever, W. J. & Britt, J. (1975). Hydatid disease in a mandrill baboon. Journal of the American Veterinary Medical Association 167, 619–21.Google Scholar
Craig, P. S. (1986). Detection of specific circulating antigen, immune complexes and antibodies in human hydatidosis from Turkana (Kenya) and Great Britain, by enzyme-immunoassay. Parasite Immunology 8, 171–88.CrossRefGoogle ScholarPubMed
Craig, P. S., Zeyhle, E. & Romig, T. (1986). Hydatid disease: research and control in Turkana. II. The role of immunological techniques for the diagnosis of hydatid disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 183–92.CrossRefGoogle ScholarPubMed
Gemmell, M. A. & Lawson, J. R. (1986). Epidemiology and control of hydatid disease. In The Biology of Echinococcus and Hydatid Disease (ed. Thompson, R. C. A.), pp. 189–216. London: George Allen & Unwin.Google Scholar
Gusbi, A. M. (1988). Studies on Echinococcus granulosus and Toxoplasma gondii in Libya. Ph.D. thesis. University of Liverpool.Google Scholar
Heath, D. D. (1973). The life cycle of Echinococcus granulosus. In Recent Advances in Hydatid Diseases (ed. Brown, R. W., Salisbury, J. R. & White, W. E.), pp. 7–18. Victoria, Australia: Hamilton Medical & Veterinary Association.Google Scholar
Macpherson, C. N. L., Else, J. E. & Suleman, M. (1986). Experimental infection of the baboon (Papio cynocephalus) with Echinococcus granulosus of camel, cattle, sheep and goat origin from Kenya. Journal of Helminthology 60, 213–17.CrossRefGoogle ScholarPubMed
Macchione, C., Arispici, M., Lanfranchi, P. & Testi, F. (1987). Experimental infection of sheep and monkeys with the camel strain of Echinococcus granulosus. In Helminth Zoonoses (ed. Geerts, S., Kumar, V. & Brandt, J.), pp. 48–54. Dordrecht, Boston and Lancaster: Martinus Nijhoff.Google Scholar
Myers, B. J., Kuntz, R. E., Vice, T. E. & Kim, C. S. (1970). Natural infection of Echinococcus granulosus in the Kenya baboon (Papio spp.). Laboratory Animal Care 20, 283–6.Google Scholar
Pinon, J. M., Poirrez, J., Lepan, H., Geers, R., Penna, R. & Fernandez, D. (1987). Value of isotypic characterization of antibodies to Echinococcus granulosus by enzyme-linked immunofiltration assay. European Journal of Clinical Microbiology 6, 291–5.CrossRefGoogle Scholar
Rickard, M. D. (1984). Serological diagnosis and postoperative surveillance of human hydatid disease. Pathology 16, 207–10.CrossRefGoogle ScholarPubMed
Rickard, M. D. & Williams, J. F. (1982). Hydatidosis/cysticercosis: immune mechanisms and immunization against infection. Advances in Parasitology 21, 229–96.CrossRefGoogle ScholarPubMed
Rogan, M. T., Craig, P. S., Zeyhle, E., Romig, T., Lubano, G. M. & Liu, D. (1991). Evaluation of a rapid dot-ELISA as a field test for the diagnosis of cystic hydatid disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 773–7.CrossRefGoogle ScholarPubMed
Romig, T. (1990). Beobachtungen zur zystischen Echinokokkose des Menschen im Turkana-Gebiet, Kenia. Ph.D. thesis, University of Hohenheim.Google Scholar
Thompson, R. C. A. & Allsop, C. E. (1988). Hydatidosis: Veterinary Perspectives and Annotated Bibliography. Wallingford: C.A.B. International.Google Scholar
Yarzabal, L. A., Leiton, J. & Lopez-Lemes, M. H. (1974). The diagnosis of human pulmonary hydatidosis by the immunoelectrophoresis test. American Journal of Tropical Medicine and Hygiene 23, 662–6.CrossRefGoogle ScholarPubMed
Yong, W. K., Heath, D. D. & Van Knapen, F. (1984). Comparison of cestode antigens in an enzyme-linked immunosorbent assay for the diagnosis of Echinococcus granulosus, Taenia hydatigena and T. ovis infections in sheep. Research in Veterinary Science 36, 24–31.CrossRefGoogle Scholar