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Pregnancy-induced recrudescences strengthen malarial immunity in mice infected with Plasmodium berghei

Published online by Cambridge University Press:  06 April 2009

A. A. J. C. Van Zon ,
W. M. C. Eling  and
C. C. Hermsen
A. A. J. C. Van Zon
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
W. M. C. Eling
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
C. C. Hermsen
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
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Extract

A considerable proportion of mice lose acquired immunity to Plasmodium berghei during the first pregnancy. Immune parous mice, however, have a better immune status than virgin mice, the risk of loss of immunity during a subsequent pregnancy is greatly reduced, the capacity to clear parasites is enhanced, and the maintenance of immunity is less dependent on certain splenic functions. The establishment of improved immunity is dependent on the presence of proliferating parasites during the second half of pregnancy when immunosup pression results in recrudescence. Immune reactivity is also improved after a (chemothera peutically controlled) recrudescent infection provoked by immunosuppressive treatment of immune mice with corticoids or anti-T cell serum. This mimics the situation encountered during pregnancy. Hence, improved immunity after pregnancy is a consequence of a reconfrontation of a suppressed and/or convalescent immune system with proliferating parasites.

Type
Research Article
Information
Parasitology , Volume 91 , Issue 1 , August 1985 , pp. 9 - 17
Copyright
Copyright © Cambridge University Press 1985

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