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Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?

Published online by Cambridge University Press:  01 May 2012

R. ALAN WILSON
R. ALAN WILSON*
Affiliation:
Centre for Immunology & Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
*
*Contact: Phone: 01904 328600. Fax: 01904 328505. E-mail: raw3@york.ac.uk
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Summary

Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The principal proteins secreted by the cercaria to gain access to the skin have been described as well as those released by migrating schistosomula. An inventory of transporters, enzymes and structural proteins has been shown to reside the tegument surface, but also immunoglobulins, complement factors and host CD44. The secreted membranocalyx that overlies the plasma membrane may contain a small number of proteins, not simply acting as physical barrier, but its lipid composition remains elusive. Analysis of worm vomitus has provided insights into blood feeding, increasing the number of known lysosomal hydrolases, and identifying a series of carrier proteins potentially involved in uptake of lipids and inorganic ions by the gut epithelium. The egg secretions that aid escape from the tissues include a mixture of MEG-2 and MEG-3 family variant proteins. The utility of identified proteins for the development of new diagnostics, and their potential as vaccines candidates is evaluated.

Keywords

Acetabular glandhead glandtegumentgut epitheliumegg secretionsmicro exon genesschistosomes
Type
Research Article
Information
Parasitology , Volume 139 , Issue 9: Symposia of the British Society for Parasitology Volume 48 Proteomic insights into parasite biology , August 2012 , pp. 1178 - 1194
Copyright
Copyright © Cambridge University Press 2012

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