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Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens

Published online by Cambridge University Press:  06 April 2009

M. Imboden ,
N. Müller ,
A. Hemphill ,
R. Mattioli  and
T. Seebeck
M. Imboden
Affiliation:
Institute of General Microbiology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
N. Müller
Affiliation:
Institut für Parasitologie, Universität Bern, Länggasstrasse 122, 3012 Bern, Switzerland
A. Hemphill
Affiliation:
Institut für Parasitologie, Universität Bern, Länggasstrasse 122, 3012 Bern, Switzerland
R. Mattioli
Affiliation:
International Trypanotolerance Centre (ITC), PMB 14, Banjul, The Gambia
T. Seebeck
Affiliation:
Institute of General Microbiology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
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Summary

Trypanosome infection of mammalian hosts leads, within days, to a strong early response against a small, distinct number of parasite proteins. One of these proteins is the variable surface glycoprotein (VSG). Most of the others are apparently non-variable, intracellular trypanosome proteins. Two of these antigens I2 and I17 are now characterized at the molecular level. Both exhibit a highly repetitive amino acid sequence organization, but they show no sequence similarity either to each other or to any other proteins known to date. Preliminary serological analyses indicate that both allow the early, sensitive and specific detection of infections with different species of trypanosomatids, making them interesting candidates for the development of diagnostic tools for trypanosomiasis detection.

Keywords

Trypanosoma brucei bruceiTrypanosoma congolenseTrypanosoma vivaxcytoskeletonrepetitive proteinantigendiagnosis.
Type
Research Article
Information
Parasitology , Volume 110 , Issue 3 , April 1995 , pp. 249 - 258
Copyright
Copyright © Cambridge University Press 1995

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