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Replication slippage and the dynamics of the immune response in malaria: a formal model for immunity

Published online by Cambridge University Press:  29 July 2005

G. DODIN  and
P. LEVOIR
G. DODIN
Affiliation:
Université Denis Diderot, ITODYS, 1 Rue Guy de la Brosse, 75005 Paris, France
P. LEVOIR
Affiliation:
Université Denis Diderot, ITODYS, 1 Rue Guy de la Brosse, 75005 Paris, France
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Abstract

A simple mathematical model of the dynamics of malaria invasion is proposed. The model is based on the hypothesis that replication slippage (slipped strand mispairing occurring in replicating DNAs), likely to take place within regular, low-complexity, regions of the plasmodium genome, is a significant mechanism of the ability for the parasite to escape the host immune defence. The model reconciles the conclusions of other formal approaches like periodic bursts of parasitaemia and, in particular, it predicts that antibody cross-reactivity affects the level and the time profile of malaria recrudescence. It also suggests that an efficient strategy for the parasite to escape host humoral immune defences is to express a single antigen. Linking local complexity to antigenic variability tentatively allows prediction of new potentially immunogenic sequences in the plasmodium genome.

Keywords

Plasmodium falciparummathematical modelimmunity
Type
Research Article
Information
Parasitology , Volume 131 , Issue 6 , December 2005 , pp. 727 - 735
Copyright
© 2005 Cambridge University Press

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