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Rodents, goats and dogs – their potential roles in the transmission of schistosomiasis in China

Published online by Cambridge University Press:  22 June 2017

CLARE F. VAN DORSSEN ,
CATHERINE A. GORDON ,
YUESHENG LI ,
GAIL M. WILLIAMS ,
YUANYUAN WANG ,
ZHENHUA LUO ,
GEOFFREY N. GOBERT ,
HONG YOU ,
DONALD P. MCMANUS  and
DARREN J. GRAY
CLARE F. VAN DORSSEN
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia School of Biomedical Sciences, University of Queensland, Brisbane, Australia
CATHERINE A. GORDON
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia
YUESHENG LI
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia Hunan Institute of Parasitic Diseases, Yueyang, Hunan, China
GAIL M. WILLIAMS
Affiliation:
School of Public Health, University of Queensland, Brisbane, Australia
YUANYUAN WANG
Affiliation:
Hunan Institute of Parasitic Diseases, Yueyang, Hunan, China
ZHENHUA LUO
Affiliation:
Hunan Institute of Parasitic Diseases, Yueyang, Hunan, China
GEOFFREY N. GOBERT
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom
HONG YOU
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia
DONALD P. MCMANUS*
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia
DARREN J. GRAY*
Affiliation:
Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia School of Public Health, University of Queensland, Brisbane, Australia Research School of Population Health, College of Medicine, Biology and Environment, The Australian National University, Canberra, Australia
*
*Corresponding authors: Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. E-mail: darren.gray@anu.edu.au and donM@qimr.edu.au
*Corresponding authors: Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. E-mail: darren.gray@anu.edu.au and donM@qimr.edu.au
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Summary

Schistosomiasis in China has been substantially reduced due to an effective control programme employing various measures including bovine and human chemotherapy, and the removal of bovines from endemic areas. To fulfil elimination targets, it will be necessary to identify other possible reservoir hosts for Schistosoma japonicum and include them in future control efforts. This study determined the infection prevalence of S. japonicum in rodents (0–9·21%), dogs (0–18·37%) and goats (6·9–46·4%) from the Dongting Lake area of Hunan province, using a combination of traditional coproparasitological techniques (miracidial hatching technique and Kato-Katz thick smear technique) and molecular methods [quantitative real-time PCR (qPCR) and droplet digital PCR (ddPCR)]. We found a much higher prevalence in goats than previously recorded in this setting. Cattle and water buffalo were also examined using the same procedures and all were found to be infected, emphasising the occurrence of active transmission. qPCR and ddPCR were much more sensitive than the coproparasitological procedures with both KK and MHT considerably underestimating the true prevalence in all animals surveyed. The high level of S. japonicum prevalence in goats indicates that they are likely important reservoirs in schistosomiasis transmission, necessitating their inclusion as targets of control, if the goal of elimination is to be achieved in China.

Keywords

Schistosoma japonicumschistosomiasisDongting LakePR ChinagoatsbovinesrodentsdogsqPCRddPCRKKMHT
Type
Special Issue Article
Information
Parasitology , Volume 144 , Special Issue 12: Glasgow encounters with tropical diseases , October 2017 , pp. 1633 - 1642
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Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

†

Authors contributed equally to this work.

References

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