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Screening and synthesis: high throughput technologies applied to parasitology

Published online by Cambridge University Press:  12 May 2005

R. E. MORGAN  and
N. J. WESTWOOD
R. E. MORGAN
Affiliation:
School of Chemistry and the Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK
N. J. WESTWOOD
Affiliation:
School of Chemistry and the Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK
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Abstract

High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compound collections are provided. The important issue of identifying the protein target(s) of bioactive compounds is discussed from the synthetic chemist's perspective. This article concludes by reviewing recent examples of successful target identification studies in parasitology.

Keywords

High throughput screeningautomated synthesisaffinity chromatographyprotozoanreviewtechnologytarget identificationchemical geneticscompound collectionphenotypic assay

Information

Type
Research Article
Information
Parasitology , Volume 128 , Issue S1 , October 2004 , pp. S71 - S79
Copyright
© 2004 Cambridge University Press

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