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Specific cross-immunity between Trichinella spiralis and Trichuris muris: immunization with heterologous infections and antigens and transfer of immunity with heterologous immune mesenteric lymph node cells

Published online by Cambridge University Press:  06 April 2009

T. D. G. Lee ,
R. K. Grencis  and
D. Wakelin
T. D. G. Lee
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
R. K. Grencis
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH
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Summary

Infections with either 300 infective Trichinella spiralis larvae or 400 embryonated eggs of Trichuris muris were effective in eliciting accelerated expulsion of heterologous challenge infections given 20 days after the primary infection. Accelerated expulsion could also be achieved by the administration of soluble crude worm antigen given 12 days prior to heterologous challenge or by adoptive transfer of mesenteric lymph node cells taken from mice infected with the heterologous parasite. Each species is capable of eliciting an accelerated secondary expulsion response in hosts that have been actively or adoptively immunized against the other species and these results are taken to indicate that there is a specific cross-immunity between T. spiralis and T. muris due to shared antigens. It is postulated that these shared antigens are derived from stichocyte granules.

Type
Research Article
Information
Parasitology , Volume 84 , Issue 2 , April 1982 , pp. 381 - 389
Copyright
Copyright © Cambridge University Press 1982

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References

Au, A. C. S. & Ko, R. C. (1979). Cross-resistance between Trichinella spiralis and Angiostrongylus cantonensis in laboratory rats. Zeitschrift für Parsitenkunde 59, 161–8.CrossRefGoogle ScholarPubMed
Bruce, R. G. (1970). Structure of the oesophagus of the infective juvenile and adult Trichinella spiralis. Journal of Parasitology 56, 540–9.CrossRefGoogle Scholar
Bruce, R. G. (1974). The formation and utilization of stichosome secretory globules in Trichinella spiralis. In Trichinellosis (ed. Kim, C.), pp. 49–57. New York: Intext Educational Publishers.Google Scholar
Bruce, R. G. & Wakelin, D. (1977). Immunological interactions between Trichinella spiralis and Trichuris muris in the intestine of the mouse. Parasitology 74, 163–73.CrossRefGoogle Scholar
Despommier, D. D. (1974). The stichocyte of Trichinella spiralis during morphogenesis in the small intestine of the rat. In Trichinellosis (ed. Kim, C.), pp. 239–54. New York: Intext Educational Publishers.Google Scholar
Despommier, D. D. & Muller, M. (1970). Functional antigens of Trichinella spiralis. Journal of Parasitology 56, 76.Google Scholar
Despommier, D. D. & Muller, M. (1976). The stichosome and its secretion granules in the mature muscle larvae of Trichinella spiralis. Journal of Parasitology 62, 775–85.CrossRefGoogle Scholar
Despommier, D. D., Campbell, W. C. & Blair, L. S. (1977). The in vivo and in vitro analysis of immunity to Trichinella spiralis in mice and rats. Parasitology 74, 109–19.CrossRefGoogle ScholarPubMed
Dineen, J. K., Gregg, P., Windon, R. G., Donald, A. D. & Kelly, J. D. (1977). The role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes. International Journal for Parasitology 7, 211–15.CrossRefGoogle ScholarPubMed
Jenkins, D. C. (1975). The influence of Nematospiroides dubius on subsequent Nippostrongylus brasiliensis infections in mice. Parasitology 71, 349–55.CrossRefGoogle ScholarPubMed
Jenkins, S. N. & Wakelin, D. (1977). The source and nature of some functional antigens of Trichuris muris. Parasitology 74, 153–61.CrossRefGoogle Scholar
Kazacos, K. R. (1975). Increased resistance in the rat to Nippostrongylus brasiliensis following immunization against Trichinella spiralis. Veterinary Parasitology 1, 165–74.CrossRefGoogle Scholar
Kennedy, M. W. (1980). Immunologically mediated non-specific interactions between the intestinal phases of Trichinella spiralis and Nippostrongylus brasiliensis in the mouse. Parasitology 80, 61–72.CrossRefGoogle ScholarPubMed
Lee, T. D. G. & Wright, K. A. (1978). The morphology of the attachment and probable feeding site of the nematode Trichuris muris. Canadian Journal of Zoology 56, 1889–1905.CrossRefGoogle ScholarPubMed
Moqbel, R. & Wakelin, D. (1979). Trichinella spiralis and Strongyloides ratti: Immune interaction in adult rats. Experimental Parasitology 47, 65–72.CrossRefGoogle ScholarPubMed
Schacterle, G. R. & Pollack, R. L. (1973). A simplified method for the qualitative assay of small amounts of protein in biological material. Analytical Biochemistry 51, 654–5.CrossRefGoogle Scholar
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–24.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975). Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the components involved. Parasitology 70, 397–405.CrossRefGoogle ScholarPubMed
Wakelin, D. (1978 a). Immunity to intestinal parasites. Nature, London 273, 617–20.CrossRefGoogle ScholarPubMed
Wakelin, D. (1978 b). Genetic control of susceptibility and resistance to parasitic infection. In Advances in Parasitology, vol. 16 (ed. Lumsden, W. H. R., Muller, R. and Baker, J. R.). New York and London: Academic Press.Google Scholar
Wakelin, D. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of the conventional parameters. Parasitology 72, 173–82.CrossRefGoogle ScholarPubMed
Wakelin, D. & Wilson, M. M. (1977). Transfer of immunity to Trichinella spiralis in the mouse with mesenteric lymph node cells: time of appearance of effective cells in donors and expression of immunity in recipients. Parasitology 74, 215–24.CrossRefGoogle Scholar
Wright, K. A. (1972). The fine structure of the esophagus of some trichuroid nematodes. I The stichosome of Capillaria hepatica, Trichuris myocastoris and Trichuris vulpis: Canadian Journal of Zoology 50, 319–24.CrossRefGoogle Scholar
Wright, K. A. (1979). Trichinella spiralis: An intracellular parasite in the intestinal phase. Journal of Parasitology 65, 441–5.CrossRefGoogle ScholarPubMed