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The SRA gene: the key to understanding the nature of Trypanosoma brucei rhodesiense

Published online by Cambridge University Press:  06 May 2005

W. C. GIBSON
Affiliation:
School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK

Abstract

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Type
Review Article
Copyright
2005 Cambridge University Press

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References

REFERENCES

ALLSOPP, R. & BALDRY, D. A. T. ( 1972). A general description of the Lambwe valley area of South Nyanza District, Kenya. Bulletin of the World Health Organization 47, 691697.Google Scholar
APTED, F. I. C. ( 1962). Sleeping sickness in Tanganyika, past, present, and future. Transactions of the Royal Society of Tropical Medicine and Hygiene 56, 1529.CrossRefGoogle Scholar
ASHCROFT, M. T. ( 1959). A critical review of the epidemiology of human trypanosomiasis in Africa. Tropical Diseases Bulletin 56, 10731093.Google Scholar
BAKER, J. R. ( 1962). Infection of the chimpanzee (Pan troglodytes verus) with Trypanosoma rhodesiense and T. brucei. Annals of Tropical Medicine and Parasitology 56, 216217.CrossRefGoogle Scholar
BAKER, J. R. & TAYLOR, A. E. R. ( 1971). Experimental infections of the chimpanzee (Pan troglodytes) with Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Annals of Tropical Medicine and Parasitology 65, 471485.CrossRefGoogle Scholar
BITEAU, N., BRINGAUD, F., GIBSON, W., TRUC, P. & BALTZ, T. ( 2000). Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers. Molecular and Biochemical Parasitology 105, 185201.CrossRefGoogle Scholar
BITTER, W., GERRITS, H., KIEFT, R. & BORST, P. ( 1998). The role of transferrin-receptor variation in the host range of Trypanosoma brucei. Nature, London 391, 499502.CrossRefGoogle Scholar
BRUN, R. & JENNI, L. ( 1987). Human serum resistance of metacyclic forms of Trypanosoma brucei brucei, T. brucei rhodesiense and T. brucei gambiense. Parasitology Research 73, 218223.Google Scholar
CAMPILLO, N. & CARRINGTON, M. ( 2003). The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology 127, 7984.CrossRefGoogle Scholar
COLEMAN, P. G. & WELBURN, S. C. ( 2004). Are fitness costs associated with resistance to human serum in Trypanosoma brucei rhodesiense? Trends in Parasitology 20, 311315.Google Scholar
DE GREEF, C., CHIMFWEMBE, E., KIHANG'A WABACHA, J., BAJYANA SONGA, E. & HAMERS, R. ( 1992). Only the serum-resistant bloodstream forms of Trypanosoma brucei rhodesiense express the serum resistance associated (SRA) protein. Annales de la Société Belge de Medecine Tropicale 72, 1321.Google Scholar
DE GREEF, C. & HAMERS, R. ( 1994). The serum resistance associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a VSG-like protein. Molecular and Biochemical Parasitology 68, 277284.CrossRefGoogle Scholar
DE GREEF, C., IMBERECHTS, H., MATTHYSSONS, G., VAN MEIRVENNE, N. & HAMERS, R. ( 1989). A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology 36, 169176.CrossRefGoogle Scholar
DUCHATEAU, P. N., PULLINGER, C. R., CHO, M. H., ENG, C. & KANE, J. P. ( 2001). Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. Journal of Lipid Research 42, 620630.Google Scholar
FAUST, S. N., WOODROW, C. J., PATEL, S., SNAPE, M., CHIODINI, P. L., TUDOR-WILLIAMS, G. & LYALL, E. G. H. ( 2004). Sleeping sickness in brothers in London. Pediatric Infectious Disease Journal 23, 879881.CrossRefGoogle Scholar
FEVRE, E. M., COLEMAN, P. G., ODIIT, M., MAGONA, J. W., WELBURN, S. C. & WOOLHOUSE, M. E. J. ( 2001). The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda. Lancet 358, 625628.CrossRefGoogle Scholar
GIBSON, W., BACKHOUSE, T. & GRIFFITHS, A. ( 2002). The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa. Infection, Genetics and Evolution 1, 207214.CrossRefGoogle Scholar
GIBSON, W. & FERRIS, V. ( 2003). Conservation of the genomic location of the human serum resistance associated gene in Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology 130, 159162.CrossRefGoogle Scholar
GIBSON, W. C. ( 1986). Will the real Trypanosoma brucei gambiense please stand up? Parasitology Today 2, 255257.Google Scholar
GIBSON, W. C. ( 1989). Analysis of a genetic cross between Trypanosoma brucei rhodesiense and T. b. brucei. Parasitology 99, 391402.CrossRefGoogle Scholar
GIBSON, W. C., FASE-FOWLER, F. & BORST, P. ( 1985). Further analysis of intraspecific variation in Trypanosoma brucei using restriction site polymorphisms in the maxi-circle of kinetoplast DNA. Molecular and Biochemical Parasitology 15, 2136.CrossRefGoogle Scholar
GIBSON, W. C. & GASHUMBA, J. K. ( 1983). Isoenzyme characterisation of some Trypanozoon stocks from a recent trypanosomiasis epidemic in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 114118.CrossRefGoogle Scholar
GIBSON, W. C., MARSHALL, T. F. D. C. & GODFREY, D. G. ( 1980). Numerical analysis of enzyme polymorphism: a new approach to the epidemiology and taxonomy of trypanosomes of the subgenus Trypanozoon. Advances in Parasitology 18, 175246.CrossRefGoogle Scholar
GIBSON, W. C. & WELLDE, B. T. ( 1985). Characterisation of Trypanozoon stocks from the South Nyanza sleeping sickness focus in Western Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 671676.CrossRefGoogle Scholar
GODFREY, D. G., BAKER, R. D., RICKMAN, L. R. & MEHLITZ, D. ( 1990). The distribution, relationships and identification of enzymic variants within the subgenus Trypanozoon. Advances in Parasitology 29, 174.CrossRefGoogle Scholar
HAWKING, F. ( 1976 a). The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense. I. Analysis of the composition of trypanosome strains. Transactions of the Royal Society of Tropical Medicine and Hygiene 70, 504520.Google Scholar
HAWKING, F. ( 1976 b). The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense. II. Survey of strains from East Africa and Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene 70, 513520.Google Scholar
HAWKING, F., RAMSDEN, D. B. & WHYTOCK, S. ( 1973). The trypanocidal action of human serum and of baboon plasma. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 501516.CrossRefGoogle Scholar
HIDE, G., BUCHANAN, N., WELBURN, S., MAUDLIN, I., BARRY, J. D. & TAIT, A. ( 1991). Trypanosoma brucei rhodesiense: characterisation of stocks from Zambia, Kenya, and Uganda using repetitive DNA probes. Experimental Parasitology 72, 430439.CrossRefGoogle Scholar
HIDE, G., CATTAND, P., LE RAY, D., BARRY, D. J. & TAIT, A. ( 1990). The identification of Trypanosoma brucei subspecies using repetitive DNA sequences. Molecular and Biochemical Parasitology 39, 213226.CrossRefGoogle Scholar
HIDE, G., WELBURN, S. C., TAIT, A. & MAUDLIN, I. ( 1994). Epidemiological relationships of Trypanosoma brucei stocks from South East Uganda: evidence for different population structures in human infective and non-infective isolates. Parasitology 109, 95111.CrossRefGoogle Scholar
HUTCHINSON, O. C., FEVRE, E. M., CARRINGTON, M. & WELBURN, S. C. ( 2003). Lessons learned from the emergence of a new Trypanosoma brucei rhodesiense sleeping sickness focus in Uganda. Lancet Infectious Diseases 3, 4245.CrossRefGoogle Scholar
JELINEK, T., BISOFFI, Z., BONAZZI, L., VAN THIEL, P., BRONNER, U., DE FREY, A., GUNDERSEN, S. G., McWHINNEY, P. & RIPAMONTI, D. ( 2002). Cluster of African trypanosomiasis in travelers to Tanzanian national parks. Emerging Infectious Diseases 8, 634635.CrossRefGoogle Scholar
JENNI, L. & BRUN, R. ( 1982). A new in vitro test for human serum resistance of Trypanosoma (T.) brucei. Acta Tropica 39, 281284.Google Scholar
JENNI, L., MARTI, S., SCHWEIZER, J., BETSCHART, B., LEPAGE, R. W. F., WELLS, J. M., TAIT, A., PAINDAVOINE, P., PAYS, E. & STEINERT, M. ( 1986). Hybrid formation between African trypanosomes during cyclical transmission. Nature, London 322, 173175.CrossRefGoogle Scholar
KOMBA, E. K., KIBONA, S. N., AMBWENE, A. K., STEVENS, J. R. & GIBSON, W. C. ( 1997). Genetic diversity among Trypanosoma brucei rhodesiense isolates from Tanzania. Parasitology 115, 571579.CrossRefGoogle Scholar
MacLEAN, L., CHISI, J. E., ODIIT, M., GIBSON, W. C., FERRIS, V., PICOZZI, K. & STERNBERG, J. M. ( 2004). Severity of Human African Trypanosomiasis in East Africa is associated with geographic location, parasite genotype and host-inflammatory cytokine response profile. Infection and Immunity 72, 70407044.CrossRefGoogle Scholar
MacLEOD, A., TURNER, C. M. R. & TAIT, A. ( 1999). A high level of mixed Trypanosoma brucei infections in tsetse flies detected by three hypervariable minisatellites. Molecular and Biochemical Parasitology 102, 237248.CrossRefGoogle Scholar
MacLEOD, A., TWEEDIE, A., WELBURN, S. C., MAUDLIN, I., TURNER, C. M. R. & TAIT, A. ( 2000). Minisatellite marker analysis of Trypanosoma brucei: Reconciliation of clonal, panmictic, and epidemic population genetic structures. Proceedings of the National Academy of Sciences, USA 97, 1344213447.CrossRefGoogle Scholar
MEHLITZ, D., ZILLMANN, U., SCOTT, C. M. & GODFREY, D. G. ( 1982). Epidemiological studies on the animal reservoir of gambiense sleeping sickness. III. Characterisation of Trypanozoon stocks by isoenzymes and sensitivity to human serum. Tropenmedizin und Parasitologie 33, 113118.Google Scholar
MILNER, J. D. & HAJDUK, S. L. ( 1999). Expression and localization of serum resistance associated protein in Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology 104, 271283.CrossRefGoogle Scholar
MONAJEMI, H., FONTIJN, R. D., PANNEKOEK, H. & HORREVOETS, A. J. G. ( 2002). The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Genomics 79, 539546.CrossRefGoogle Scholar
MOORE, D. R., SMITH, A., HAGER, K. M., WALDON, R., ESKO, J. D. & HAJDUK, S. L. ( 1995). Developmentally-regulated sensitivity of Trypanosoma brucei brucei to the cytotoxic effects of human high density lipoprotein. Experimental Parasitology 81, 216226.CrossRefGoogle Scholar
NJIRU, Z. K., NDUNG'U, K., MATETE, G., NDUNGU, J. M. & GIBSON, W. C. ( 2004). Detection of Trypanosoma brucei rhodesiense in animals from sleeping sickness foci in East Africa using the serum resistance associated (SRA) gene. Acta Tropica 90, 249254.CrossRefGoogle Scholar
ONYANGO, R. J., VAN HOEVE, K. & DE RAADT, P. ( 1966). The epidemiology of Trypanosoma rhodesiense sleeping sickness in Alego location, Central Nyanza, Kenya. I. Evidence that cattle may act as reservoir hosts of trypanosomes infective to man. Transactions of the Royal Society of Tropical Medicine and Hygiene 60, 175182.Google Scholar
ORMEROD, W. E. ( 1967). Taxonomy of the sleeping sickness trypanosomes. Journal of Parasitology 53, 824830.CrossRefGoogle Scholar
PAGE, N. M., BUTLIN, D. J., LOMTHAISONG, K. & LOWRY, P. J. ( 2001). The human apolipoprotein L gene cluster: Identification, classification, and sites of distribution. Genomics 74, 7178.CrossRefGoogle Scholar
POELVOORDE, P., VANHAMME, L., VAN DEN ABBEELE, J., SWITZER, W. M. & PAYS, E. ( 2004). Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera. Molecular and Biochemical Parasitology 134, 155157.CrossRefGoogle Scholar
RADWANSKA, M., CHAMEKH, M., VANHAMME, L., CLAES, F., MAGEZ, S., MAGNUS, E., DE BAETSELIER, P., BUSCHER, P. & PAYS, E. ( 2002). The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense. American Journal of Tropical Medicine and Hygiene 67, 684690.CrossRefGoogle Scholar
RAPER, J., PORTELA, M. P. M., LUGLI, E., FREVERT, U. & TOMLINSON, S. ( 2001). Trypanosome lytic factors: novel mediators of human innate immunity. Current Opinion in Microbiology 4, 402408.CrossRefGoogle Scholar
RICKMAN, L. R. ( 1977). Variation in the test response of clone-derived Trypanosoma (Trypanozoon) brucei brucei and T. (T.) b. rhodesiense relapse antigenic variants, examined by a modified blood incubation infectivity test and its possible significance in rhodesian sleeping sickness transmission. Medical Journal of Zambia 11, 3141.Google Scholar
RICKMAN, L. R. & ROBSON, J. ( 1970). The testing of proven Trypanosoma brucei and T. rhodesiense strains by the blood incubation infectivity test. Bulletin of the World Health Organization 42, 911916.Google Scholar
RIFKIN, M. R. ( 1978). Identification of the trypanocidal factor in normal human serum: high density lipoprotein. Proceedings of the National Academy of Sciences, USA 75, 34503454.CrossRefGoogle Scholar
RUDENKO, G., CROSS, M. & BORST, P. ( 1998). Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes. Trends in Microbiology 6, 113117.CrossRefGoogle Scholar
SEED, J. R., SECHELSKI, J. B. & LOOMIS, M. R. ( 1990). A survey for a trypanocidal factor in primate sera. Journal of Protozoology 37, 393400.CrossRefGoogle Scholar
STEPHENS, J. & FANTHAM, H. ( 1910). On the peculiar morphology of a trypanosome from a case of sleeping sickness and the possibility of its being a new species (T. rhodesiense). Annals of Tropical Medicine and Parasitology 4, 343350.CrossRefGoogle Scholar
TAIT, A., BARRY, J. D., WINK, R., SANDERSON, A. & CROWE, J. S. ( 1985). Enzyme variation in Trypanosoma brucei spp. II. Evidence for T. b. rhodesiense being a set of variants of T. b. brucei. Parasitology 90, 89100.Google Scholar
TARGETT, G. A. T. & WILSON, V. C. L. C. ( 1973). The blood incubation infectivity test as a means of distinguishing between Trypanosoma brucei brucei and T. brucei rhodesiense. International Journal for Parasitology 3, 511.CrossRefGoogle Scholar
TAUTE, M. & HUBER, F. ( 1919). Die Unterscheidung des Trypanosoma rhodesiense vom Trypanosoma brucei. Beobachtungen und Experimente aus dem Kriege in Ostafrika. Archiv für Schiffs- und Tropen-Hygiene 23, 212234.Google Scholar
TURNER, C. M. R., McLELLAN, S., LINDERGARD, L. A. G., BISONI, L., TAIT, A. & MacLEOD, A. ( 2004). Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression. Parasitology, 129, 445454.CrossRefGoogle Scholar
VAN MEIRVENNE, N., MAGNUS, E. & JANSSENS, P. G. ( 1976). The effect of normal human serum on trypanosomes of distinct antigenic type (ETat 1–12) isolated from a strain of Trypanosoma brucei rhodesiense. Annales de la Société Belge de Medecine Tropicale 56, 5563.Google Scholar
VANHAMME, L., PATURIAUX-HANOCQ, F., POELVOORDE, P., NOLAN, D., LINS, L., VAN DEN ABBEELE, J., PAYS, A., TEBABI, P., XONG, H., JACQUET, A., MOGUILEVSKY, N., DIEU, M., KANE, J. P., DE BAETSELIER, P., BRASSEUR, R. & PAYS, E. ( 2003). Apolipoprotein L-1 is the trypanosome lytic factor of human serum. Nature, London 422, 8387.CrossRefGoogle Scholar
VANHAMME, L., RENAULD, H., LECORDIER, L., POELVOORDE, P., VAN DEN ABBEELE, J. & PAYS, E. ( 2004). The Trypanosoma brucei reference strain TREU927/4 contains T. brucei rhodesiense-specific SRA sequences, but displays a distinct phenotype of relative resistance to human serum. Molecular and Biochemical Parasitology 135, 3947.Google Scholar
WELBURN, S. C., PICOZZI, K., FEVRE, E. M., COLEMAN, P. G., ODIIT, M., CARRINGTON, M. & MAUDLIN, I. ( 2001). Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene. Lancet 358, 20172019.CrossRefGoogle Scholar
WELLDE, B. T., CHUMO, D. A., REARDON, M. J., WAEMA, D., SMITH, D. H., GIBSON, W. C., WANYAMA, L. & SIONGOK, T. A. ( 1989 a). Epidemiology of Rhodesian sleeping sickness in the Lambwe Valley, Kenya. Annals of Tropical Medicine and Parasitology 83, 4362.Google Scholar
WELLDE, B. T., WAEMA, D., CHUMO, D. A., REARDON, M. J., OLOO, F., NJOGU, A. R., OPIYO, E. A. & MUGUTU, S. ( 1989 b). Review of tsetse control measures taken in the Lambwe Valley in 1980–1984. Annals of Tropical Medicine and Parasitology 83, 119125.Google Scholar
WILLETT, K. & FAIRBAIRN, H. ( 1955). The Tinde experiment: A study of Trypanosoma rhodesiense during eighteen years of cyclical transmission. Annals of Tropical Medicine and Parasitology 49, 278292.CrossRefGoogle Scholar
XONG, V. H., VANHAMME, L., CHAMEKH, M., CHIMFWEMBE, C. E., VAN DEN ABBEELE, J., PAYS, A., VAN MEIRVENNE, N., HAMERS, R., DE BAETSELIER, P. & PAYS, E. ( 1998). A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell 95, 839846.CrossRefGoogle Scholar
YORKE, W. ( 1910). On the pathogenicity of a trypanosome (T. rhodesiense, Stephens and Fantham) from a case of sleeping sickness contracted in Rhodesia. Annals of Tropical Medicine and Parasitology 4, 351368.Google Scholar
ZILLMANN, U., MEHLITZ, D. & SACHS, R. ( 1984). Identity of Trypanozoon stocks isolated from man and domestic dog in Liberia. Tropenmedizin und Parasitologie 35, 105108.Google Scholar