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Strongyloides ratti (homogonic): the time-course of early migration in the generalized host deduced from experiments in lactating rats

Published online by Cambridge University Press:  06 April 2009

P. A. G. Wilson ,
Gillian E. Steven  and
Norma E. Simpson
P. A. G. Wilson
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
Gillian E. Steven
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
Norma E. Simpson
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
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Extract

Unsuckled mother rats given a 1 h suckling stimulus 3 h after subcutaneous injection of an exact dose of homogonic Strongyloides ratti allow fewer worms to develop in their intestines by day 8 than nulliparous rats (Wilson & Simpson, 1981). This effect is studied in more detail in terms of the length of time between weaning and stimulus (W → S) and injection and stimulus (I → S). It was observable with a W → S of 30 h but this and a period of 5 h were less effective than 24 h. With W → S constant at 24 h, significantly more worms developed in mothers when I → S was 24 h compared to 3 h and 10 h (P < 0·005). The data, combined with those from nulliparous controls, are presented as a measure of the change with time of numbers of larvae in that compartment of the system which gives access to the stimulated mammary gland. It is argued that the particular compartment is the local lymph node draining the injection site and that the kinetics deduced are applicable to migration in the rat in general

Type
Research Article
Information
Parasitology , Volume 85 , Issue 3 , December 1982 , pp. 533 - 542
Copyright
Copyright © Cambridge University Press 1982

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References

Abadie, S. (1963). The life-cycle of Strongyloidea ratti. Journal of Parasitology 49, 241–8.CrossRefGoogle Scholar
Bell, R. G., Adams, L. S. & Gerb, J. (1981). Strongyloides ratti: Dissociation of the rat's protective immunity into systemic and intestinal components. Experimental Parasitology 52, 386–95.CrossRefGoogle ScholarPubMed
Clarke, K. R. (1967). The migratory route of third stage larvae of Nippostrongylus brasiliensis (Travassos 1914). Journal of Helminthology 41, 285–90.CrossRefGoogle Scholar
Fülleborn, F. (1914). Untersuchungen iiber den Infektionsweg bei Strongyloides und Ancylo- stomen und die Biologie dieser Parasiten. Archiv filr Schiffs und Tropenhygiene 18, 182–236 (Festschrift zur Eroffnung des neuen Instituts fiir Schiffs-und Tropenkrankheiten zu Hamburg. Verfasst von dem Mitgliedern des Instituts, pp. 26–80).Google Scholar
Fülleborn, F. (1929). On the larval migration of some parasitic nematodes in the body of the host and its biological significance. Journal of Helminthology 7, 15–26.CrossRefGoogle Scholar
Gharib, H. M. (1961). On the migration route of the infective larvae of Nippostrongylus brasiliensis. Journal of Helminthology 35, 101–8.CrossRefGoogle ScholarPubMed
Looss, A. (1905). Wanderung der Ancylostomum- und Strongyloides-Larven von der Haut nach dem Darm. Comptes Rendus de 6e Congrés internationale de Zoologie, Berne, 1904, 225–33.Google Scholar
Looss, A. (1911). The anatomy and life-history of Agchylostoma duodenale Dub. Part II. The development in the free state. Records of the Egyptian Government School of Medicine 4, Monograph, 446 pp: Cairo.Google Scholar
Love, R. J., Kelly, J. D. & Dineen, J. K. (1974). Nippostrongylus brasiliensis: Effects of immunity on the pre-intestinal and intestinal larval stages of the parasite. International Journal for Parasitology 4, 183–91.CrossRefGoogle ScholarPubMed
Murrell, K. D. (1980). Strongyloides ratti: Acquired resistance in the rat to preintestinal migrating larvae. Experimental Parasitology 50, 417–25.CrossRefGoogle ScholarPubMed
Murrell, K. D. (1981). Protective role of immunoglobulin G in immunity to Strongyloides ratti. Journal of Parasitology 67, 167–73.CrossRefGoogle ScholarPubMed
Oshio, Y. (1956). Studies on the migration of the larvae of Strongyloides ransomi. Bulletin of the National Institute of Agricultural Science, Chiba, Series G, Animal Husbandry 12, 106–11. (In Japanese.)Google Scholar
Tada, I., Mimori, T. & Nakai, M. (1979). Migragtion route of Strongyloides ratti in albino rats Japanese Journal of Parasitology 28, 219–27.Google Scholar
Twohy, D. W. (1956). The early migration and growth of Nippostrongylus brasiliensis in the rat. American Journal of Hygiene 63, 165–85.Google Scholar
Wertheim, G. & Lengy, J. (1965). Growth and development of Strongyloides ratti Sandground 1925, in the albino rat. Journal of Parasitology 51, 636–9.CrossRefGoogle ScholarPubMed
Wilson, P. A. G. (1977). The effect of the suckling stimulus on the migration of Strongyloides ratti in lactating rats. Parasitology 75, 233–9.CrossRefGoogle ScholarPubMed
Wilson, P. A. G.(1979). Tracking radioactive larvae of Strongyloides ratti in the host. Parasitology 79, 29–38.CrossRefGoogle ScholarPubMed
Wilson, P. A. G. (1980 a). Migration of larval roundworms in the rat. Parasitology 81, xi.Google Scholar
Wilson, P. A. G. (1980 b). Recirculation of Strongyloides larvae in the blood of rats and the use of the mammary gland as a sampling device. Proceedings of the Third European Multicolloquium of Parasitology, Abstract 15.Google Scholar
Wilson, P. A. G. (1982). Roundworm juvenile migration in mammals: the pathways of skin-penetrators reconsidered. In Aspects of Parasitology – A Festschrift dedicated to the 50th anniversary of the Institute of Parasitology, McGill University, 1932–1982, (ed. Meerovitch, E.). Institute of Parasitology, Montreal (in the Press).Google Scholar
Wilson, P. A. G., Gentle, M. & Scott, D. S. (1976 a). Milk-borne infection of rats with Strongyloides ratti and Nippostrongyltis brasiliensis. Parasitology 72, 355–60.CrossRefGoogle ScholarPubMed
Wilson, P. A. G., Gentle, M. & Scott, D. S. (1976 b). Dynamic determinants of the route of larval Strongyloides ratti in lactating rats and the control of experimental error in quantitative studies of milk transmission of skin penetrating roundworms. Parasitology 73, 399–406.CrossRefGoogle ScholarPubMed
Wilson, P. A. G. & Simpson, N. E. (1981). Dynamics of infection in rats given low doses of homogonic and heterogonic Strongyloides ratti. Parasitology 83, 459–75.CrossRefGoogle Scholar
Wilson, P. A. G. & Simpson, N. E. (1982). Strongyloides ratti: studies of 75Se labelled larvae of the homogonic strain in female hosts. Parasitology 84, 443–54.CrossRefGoogle ScholarPubMed
Yokogawa, S. (1922). The development of Heligmosomum muris Yokogawa, a nematode from the intestine of the wild rat. Parasitology 14, 127–66.CrossRefGoogle Scholar