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Toxoplasmosis in pregnancy: a neglected bane but a serious threat in Nigeria

Published online by Cambridge University Press:  06 November 2019

Oyetunde T. Oyeyemi*
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria Diagnosis and Therapy of Infectious Diseases and Cancer Laboratory, René Rachou Institute, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Ifeoluwa T. Oyeyemi
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria
Isaac A. Adesina
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria
Adebisi M. Tiamiyu
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria
Yinka D. Oluwafemi
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria
Roseangela I. Nwuba
Affiliation:
Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria
Rafaella F. Q. Grenfell
Affiliation:
Diagnosis and Therapy of Infectious Diseases and Cancer Laboratory, René Rachou Institute, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
*
Author for correspondence: Oyetunde T. Oyeyemi, E-mail: ooyeyemi@unimed.edu.ng

Abstract

Toxoplasmosis is a global health threat in which occurrence in pregnant women poses grave consequences to fetal wellbeing. Studies on prenatal Toxoplasma gondii infection are generally limited in sub-Saharan African countries, including Nigeria. The risk of transmission of toxoplasmosis is very high in Nigeria due to the favourable climatic conditions and prevailing behavioural and socio-economic factors that could aid transmission. Currently, there are no systematic and organized procedures for diagnosis and treatment of maternal toxoplasmosis in Nigeria. These conditions forecast possible unabated transmission in many areas and exponential impact on associated adverse events of the disease during pregnancy. This paper highlights the importance of early diagnosis and treatment during pregnancy which may forestall subsequent development of infection in children delivered by infected mothers. Inclusion of toxoplasmosis control policy in the routine antenatal care of pregnant women is therefore strongly recommended.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2019

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References

Abdel-Raouff, M and Elbasheir, MM (2014) Sero-prevalence of Toxoplasma gondii infection among pregnant women attending antenatal clinics in Khartoum and Omdurman Maternity Hospitals, Sudan. Journal of Coastal Life Medicine 2, 496499.Google Scholar
Adou-Bryn, KD, Ouhon, J, Nemer, J, Yapo, CG and Assoumou, A (2004) Serological survey of acquired toxoplasmosis in women of child-bearing age in Yopougon (Abidjan, Côte d'Ivoire). Bulletin de la Société de Pathologie Exotique 97, 345348.Google Scholar
Afonso, E, Thulliez, P and Gilot-Fromont, E (2010) Local meteorological conditions, dynamics of seroconversion to Toxoplasma gondii in cats (Felis catus) and oocyst burden in a rural environment. Epidemiology and Infection 138, 11051113.CrossRefGoogle Scholar
Afonso, E, Germain, E, Poulle, ML, Ruette, S, Devillard, S, Say, L, Aubert, D and Gilot-Fromont, E (2013) Environmental determinants of spatial and temporal variations in the transmission of Toxoplasma gondii in its definitive hosts. International Journal of Parasitology: Parasites and Wild Life 2, 278285.Google ScholarPubMed
Ahmed, HJ, Mohammed, HH, Yusuf, MW, Ahmed, SF and Huldt, G (1988) Human toxoplasmosis in Somalia. Prevalence of Toxoplasma antibodies in a village in the lower Scebelli region and in Mogadishu. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 330332.CrossRefGoogle Scholar
Akinbami, A, Adewunmi, AA, Rabiu, KA, Wright, KO, Dosunmu, AO, Dada, MO and Adeyemo, TA (2010) Seroprevalence of Toxoplasma gondii antibodies amongst pregnant women at Lagos State University Teaching Hospital. International Journal of Infectious Diseases 14, e288.CrossRefGoogle Scholar
Alayande, MO, Edungbola, LD, Fabiyi, JP and Awosan, KJ (2013) Occurrence of antibody to Toxoplasma infection among pregnant women with obstetric histories and at different trimesters in Sokoto, Northwest Nigeria. American Journal of Research Communication 1, 240247.Google Scholar
Amadi, OF, Ndu, IK, Chinawa, JM, Jean, NC and Obidi, NO (2015) Toxoplasmosis in a 17-month-old Nigerian: a case report. Annals of Tropical Medicine and Public Health 8, 6466.Google Scholar
Ander, SE, Rudzki, EN, Arora, N, Sadovsky, Y, Coyne, CB and Boyle, JP (2018) Human placental syncytiotrophoblasts restrict Toxoplasma gondii attachment and replication and respond to infection by producing immunomodulatory chemokines. MBio 9, 114.CrossRefGoogle ScholarPubMed
Andrade, GM, Vasconcelos-Santos, DV, Carellos, EV, Romanelli, RM, Vitor, RW, Carneiro, AC and Januario, JN (2009) Congenital toxoplasmosis from a chronically infected woman with reactivation of retinochoroiditis during pregnancy – an underestimated event? Jornal de Pediatria 86, 8588.CrossRefGoogle Scholar
Awobode, HO and Olubi, IC (2014) Prevalence of Toxoplasma gondii and HIV infection among pregnant women in Ibadan North Local Government, Oyo State. African Journal of Medicine and Medical Sciences 43(suppl.), 3945.Google ScholarPubMed
Ayi, I, Sowah, AO, Blay, EA, Suzuki, T, Ohta, N and Ayeh-Kumi, PF (2016) Toxoplasma gondii infections among pregnant women, children and HIV-seropositive persons in Accra, Ghana. Tropical Medicine and Health 44, 18. doi:10.1186/s41182-016-0018-5.CrossRefGoogle ScholarPubMed
Barbosa, BF, Silva, DA, Costa, IN, Mineo, JR and Ferro, EA (2008) Bewo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferon-gamma, interleukin-10 and transforming growth factor-beta1. Clinical & Experimental Immunology 151, 536545.CrossRefGoogle ScholarPubMed
Bachmeyer, C, Mouchnino, G, Thulliez, P and Blum, L (2006) Congenital toxoplasmosis from an HIV-infected woman as a result of reactivation. Journal of Infection 52, 5557.CrossRefGoogle ScholarPubMed
Ballah, FM, Maikai, BV, Magaji, AA, Shuaibu, AB, El-Nafaty, AU, Sambo, YT, Auwal, AA, Faruk, HU and Suleiman, F (2017) Seroprevalence and risk of Toxoplasma gondii infection among pregnant women at Federal Teaching Hospital Gombe, Nigeria. Asian Journal of Medicine and Health 3, 15.CrossRefGoogle Scholar
Bamba, S, Cissé, M, Sangaré, I, Zida, A, Ouattara, S and Guiguemdé, RT (2017) Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women from Bobo Dioulasso, Burkina Faso. BMC Infectious Diseases 17, 482.CrossRefGoogle ScholarPubMed
Barragan, A, Brossier, F and Sibley, LD (2005) Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cellular Microbiology 7, 561568.CrossRefGoogle ScholarPubMed
Begeman, IJ, Lykins, J, Zhou, Y, Lai, BS, Levigne, P, El Bissati, K, Boyer, K, Withers, S, Clouser, F, Noble, AG, Rabiah, P, Swisher, CN, Heydemann, PT, Contopoulos-Ioannidis, DG, Montoya, JG, Maldonado, Y, Ramirez, R, Press, C, Stillwaggon, E, Peyron, F and McLeod, R (2017) Point-of-care testing for Toxoplasma gondii IgG/IgM using toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries. PLoS Neglected Tropical Diseases 11, e0005670. https://doi.org/10.1371/journal.pntd.0005670.CrossRefGoogle Scholar
Borges, M, Silva, TM, Brito, C, Teixeira, N and Roberts, CW (2019) How does toxoplasmosis affect the maternal-fetal immune interface and pregnancy? Parasite Immunology 41, 111, e12606.CrossRefGoogle Scholar
Capretti, MG, De Angelis, M, Tridapalli, E, Orlandi, A, Marangoni, A, Moroni, A, Guerra, B, Arcuri, S, Marsico, C and Faldella, G (2014) Toxoplasmosis in pregnancy in an area with low seroprevalence: is prenatal screening still worthwhile? The Pediatric Infectious Disease Journal 33, 510.CrossRefGoogle Scholar
Carlier, Y, Truyens, C, Deloron, P and Peyron, F (2012) Congenital parasitic infections: a review. Acta Tropica 121, 55.CrossRefGoogle ScholarPubMed
Chapey, E, Wallon, M and Peyron, F (2017) Evaluation of the LDBIO point of care test for the combined detection of toxoplasmic IgG and IgM. Clinica Chimica Acta 464, 200201.CrossRefGoogle ScholarPubMed
Chaudhry, SA, Gad, N and Koren, G (2014) Toxoplasmosis and pregnancy. Canadian Family Physician 60, 334336.Google Scholar
Deji-Agboola, AM, Busari, OS, Osinupebi, OA and Amoo, AO (2011) Seroprevalence of Toxoplasma gondii antibodies among pregnant women attending Antenatal Clinic of Federal Medical Center, Lagos, Nigeria. International Journal of Biological and Medical Research 2, 11351139.Google Scholar
Develoux, M, Chandenierj, J and Tinni, A (1989) Toxoplasmosis in pregnant women in Niamey (Niger). Bulletin de la Société de Pathologie Exotique 82, 406409.Google Scholar
Doudou, Y, Renaud, P, Coralie, L, Jacqueline, F, Hypolite, S, Hypolite, M, Patrick, M, Andreia Ida, L, Van Sprundel, M, Marleen, B, Van Geertruyden, JP and Pascal, L (2014) Toxoplasmosis among pregnant women: high seroprevalence and risk factors in Kinshasa, Democratic Republic of Congo. Asian Pacific Journal of Tropical Biomedicine 4, 6974..CrossRefGoogle Scholar
Denkers, EY and Gazzinelli, RT (1998) Regulation and function of T-cell mediated immunity during Toxoplasma gondii infection. Clinical Microbiology Reviews 11, 569588.CrossRefGoogle ScholarPubMed
Dubey, JP and Frenkel, JK (1972) Cyst-induced toxoplasmosis in cats. Journal of Protozoology 19, 155177.CrossRefGoogle ScholarPubMed
Dubey, JP, Tiao, N, Gebreyes, WA and Jones, JL (2012) A review of toxoplasmosis in humans and animals in Ethiopia. Epidemiology and Infection 140, 19351938.CrossRefGoogle ScholarPubMed
Elmore, SA, Jones, JL, Conrad, PA, Patton, S, Lindsay, DS and Dubey, JP (2010) Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention. Trends in Parasitology 26, 190196.CrossRefGoogle Scholar
Eludoyin, OM, Adelekan, IO, Webster, R and Eludoyin, AO (2014) Air temperature, relative humidity, climate regionalization and thermal comfort of Nigeria. International Journal of Climatology 34, 20002018.CrossRefGoogle Scholar
Frimpong, C, Makasa, M, Sitali, L and Michelo, C (2017) Seroprevalence and determinants of toxoplasmosis in pregnant women attending antenatal clinic at the university teaching hospital, Lusaka, Zambia. BMC Infectious Disease 17, 18.CrossRefGoogle ScholarPubMed
Flegr, J, Prandota, J, Sovičková, M and Israili, ZH (2014) Toxoplasmosis – a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS ONE 9, 122.CrossRefGoogle Scholar
Galal, L, Ajzenberg, D, Hamidović, A, Durieux, MF, Dardé, ML and Mercier, A (2018) Toxoplasma and Africa: one parasite, two opposite population structures. Trends in Parasitology 34, 140154. https://doi.org/10.1016/j.pt.2017.10.010.CrossRefGoogle ScholarPubMed
Gamba, EP, Nambei, WS and Kamandji, L (2013) Integrated screening for HIV, syphilis, and toxoplasmosis among pregnant women in the Central African Republic. Médecine et Santé Tropicales 23, 421426.Google ScholarPubMed
Garweg, JG, Scherrer, J, Wallon, M, Kodjikian, L and Peyron, F (2005) Reactivation of ocular toxoplasmosis during pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology 112, 241242.CrossRefGoogle ScholarPubMed
Gelaye, W, Kebede, T and Hailu, A (2015) High prevalence of anti-Toxoplasma antibodies and absence of Toxoplasma gondii infection risk factors among pregnant women attending routine antenatal care in two Hospitals of Addis Ababa, Ethiopia. International Journal of Infectious Diseases 34, 4145.CrossRefGoogle ScholarPubMed
Gilbert, R (2009) Treatment for congenital toxoplasmosis: finding out what works. Memórias do Instituto Oswaldo Cruz 104, 305311.CrossRefGoogle Scholar
Gubler, DJ, Reiter, P, Ebi, KL, Yap, W, Nasci, R and Patz, JA (2001) Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases. Environmental Health Perspectives 109, 223233.Google ScholarPubMed
Halonen, SK and Weiss, LM (2013) Toxoplasmosis. Handbook of Clinical Neurology 114, 125145.CrossRefGoogle ScholarPubMed
Hayde, M and Pollak, A (2000) Clinical picture. Neonatal signs and symptoms. Congenital toxoplasmosis. pp. 153164.CrossRefGoogle Scholar
Hedman, K, Lappalainen, M, Seppäiä, I and Mäkelä, O (1989) Recent primary Toxoplasma infection indicated by a low avidity of specific IgG. Journal of Infectious Diseases 159, 736740.CrossRefGoogle ScholarPubMed
Hernández-Cortazar, I, Acosta-Viana, KY, Ortega-Pacheco, A and Guzman-Marin, ES (2015) Review. Toxoplasmosis in Mexico: epidemiological situation in humans and animals. Revista do Instituto de Medicina Tropical de São Paulo 57, 93103.CrossRefGoogle ScholarPubMed
Hohfeld, P, Daffos, F, Costa, J, Thulliez, P, Forestier, F and Vidaud, M (1994) Prenatal diagnosis of congenital toxoplasmosis with a polymerase chain reaction test on amniotic fluid. New England Journal of Medicine 331, 695699.CrossRefGoogle Scholar
Hung, CC, Fan, CK, Su, KE, Sung, FC, Chiou, HY, Gil, V, da Conceicao dos Reis Ferreira, M, de Carvalho, JM, Cruz, C, Lin, YK, Tseng, LF, Sao, KY, Chang, WC, Lan, HS and Chou, SH (2007) Serological screening and toxoplasmosis exposure factors among pregnant women in the Democratic Republic of Sao Tome and Principe. Transactions of the Royal Society of Tropical Medicine and Hygiene 101, 134139.CrossRefGoogle ScholarPubMed
Hunt, JS, Petroff, MG, McIntire, RH and Ober, C (2005) HLA-G and immune tolerance in pregnancy. FASEB Journal 19, 681693.CrossRefGoogle ScholarPubMed
Hutchison, WM, Dunachie, JF, Siim, JC and Work, K (1969) Life cycle of Toxoplasma gondii. British Medical Journal 4, 806.CrossRefGoogle ScholarPubMed
Ishaku, BS, Ajogi, I, Umoh, JU, Lawal, I and Randawa, AJ (2009) Seroprevalence and risk factors for Toxoplasma gondii infection among antenatal women in Zaria, Nigeria. Research Journal of Medical Sciences 4, 483488.Google Scholar
Jamieson, SE, de Roubaix, LA, Cortina-Borja, M, Tan, HK, Mui, EJ, Cordell, HJ, et al. (2008) Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. PLoS ONE 3, e2285.CrossRefGoogle ScholarPubMed
Jenum, PA, Stray-Pedersen, B, Melby, KK, Kapperud, G, Whitelaw, A, Eskild, A and Enj, J (1998) Incidence of Toxoplasma gondii infection in 35,940 pregnant women in Norway and pregnancy outcome for infected women. Journal of Clinical Microbiology 36, 29002906.CrossRefGoogle ScholarPubMed
Jiang, W, Sullivan, AM, Su, C and Zhao, X (2012) An agent-based model for the transmission dynamics of Toxoplasma gondii. Journal of Theoretical Biology 293, 1526.CrossRefGoogle ScholarPubMed
Juliano, PB, Blotta, MH and Altemani, AM (2006) ICAM-1 is overexpressed by villous trophoblasts in placentitis. Placenta 27, 750757.CrossRefGoogle ScholarPubMed
Kamau, P, Jaoko, W and Gontier, C (2012) Seroepidemiology of Toxoplasma gondii in ante-natal women attending Kenyatta National Hospital, Kenya. International Journal of Infectious Diseases 16, e162.CrossRefGoogle Scholar
Lelong, B, Rahelimino, B, Candolfi, E, Ravelojaona, BJ, Villard, O and Kien, T (1995) Prevalence of toxoplasmosis in a population of pregnant women in Antananarivo (Madagascar). Bulletin de la Société de Pathologie Exotique 88, 4649.Google Scholar
Li, X-L, Wei, H-X, Zhang, H, Peng, H-J and Lindsay, DS (2014) A meta analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection. PLoS ONE 9, e97775.CrossRefGoogle ScholarPubMed
Lim, H, Lee, SE, Jung, BK, Kim, MK, Lee, MY, Nam, HW, Shin, J-G, Yun, C-H, Cho, H-I, Shin, E-H and Chai, J-Y (2012) Serologic survey of toxoplasmosis in Seoul and Jeju-do, and a brief review of its seroprevalence in Korea. Korean Journal of Parasitology 50, 287293.CrossRefGoogle Scholar
Lin, YL, Liao, YS, Liao, LR, Chen, FN, Kuo, HM and He, S (2008) Seroprevalence and sources of Toxoplasma infection among indigenous and immigrant pregnant women in Taiwan. Parasitology Research 103, 6774.CrossRefGoogle ScholarPubMed
Lindstrom, I, Kaddu-Mulindwa, DH, Kironde, F and Lindh, J (2006) Prevalence of latent and reactivated Toxoplasma gondii parasites in HIV-patients from Uganda. Acta Tropica 100, 218222.CrossRefGoogle ScholarPubMed
Linguissi, LSG, Nagalo, BM, Bisseye, C, Kagoné, TS, Sanoud, M, Tao, I, Benao, V, Simporé, J and Koné, B (2012) Seroprevalence of toxoplasmosis and rubella in pregnant women attending antenatal private clinic at Ouagadougou, Burkina Faso. Asian Pacific Journal of Tropical Medicine 5, 810813.CrossRefGoogle ScholarPubMed
Ljungström, I, Gille, E, Nokes, J, Linder, E and Forsgren, M (1995) Seroepidemiology of Toxoplasma gondii among pregnant women in different parts of Sweden. European Journal of Epidemiology 11, 149156.CrossRefGoogle ScholarPubMed
Lobo, ML, Patrocinio, G, Sevivas, T, De Sousa, B and Matos, O (2017) Portugal and Angola: similarities and differences in Toxoplasma gondii seroprevalence and risk factors in pregnant women. Epidemiology and Infection 145, 3040.CrossRefGoogle ScholarPubMed
Lykins, J, Li, X, Levigne, P, Zhou, Y, El Bissati, K, Clouser, F, et al. (2018) Rapid, inexpensive, fingerstick, whole-blood, sensitive, specific, point-of-care test for anti-Toxoplasma antibodies. PLoS Neglected Tropical Diseases 12, e0006536. https://doi.org/10.1371/journal.pntd.0006536.CrossRefGoogle ScholarPubMed
Mahmoud, H, Saedi Dezaki, E, Soleimani, S, Baneshi, MR, Kheirandish, F, Ezatpour, B and Zia-Ali, N (2015) Seroprevalence and risk factors of Toxoplasma gondii infection among healthy blood donors in south-east of Iran. Parasite Immunology 37, 362367.CrossRefGoogle Scholar
Mandelbrot, L, Kieffer, F, Sitta, R, Laurichesse-Delmas, H, Winer, N, Mesnard, L, Berrebi, A, Le Bouar, G, Bory, JP, Cordier, AG, Ville, Y, Perrotin, F, Jouannic, JM, Biquard, F, d'Ercole, C, Houfflin-Debarge, V, Villena, I, Thiébaut, RL and TOXOGEST study Group (2018). Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial. American Journal of Obstetrics and Gynecology 219, 386.e1–e9.CrossRefGoogle ScholarPubMed
Meerburg, BG and Kijlstra, A (2009) Changing climate-changing pathogens: Toxoplasma gondii in North-Western Europe. Parasitology Research 105, 1724.CrossRefGoogle ScholarPubMed
Millar, PR, de Moura, FL, Bastos, OM, de Mattos, DP, Fonseca, AB, Sudré, AP, Leles, D and Amendoeira, MRR (2014) Conhecimento sobre toxoplasmose entre gestantes e puérperas atendidas na rede pública de saúde do município de Niterói, Rio de Janeiro, Brasil. Revista Do Instituto de Medicina Tropical de Sao Paulo 56, 433438.CrossRefGoogle Scholar
Montoya, JG (2002) Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. Journal of Infectious Diseases 185, S73S82.CrossRefGoogle ScholarPubMed
Montoya, JG and Remington, JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clinical Infectious Diseases 47, 554566.CrossRefGoogle ScholarPubMed
Morvan, JM, Mambely, R, Selekon, B and Coumanzi-Malo, MF (1999) Toxoplasmosis at the Pasteur Institute of Bangui, Central African Republic (1996–1998): serological data. Bulletin de la Société de Pathologie Exotique 92, 157160.Google ScholarPubMed
Moukandja, IP, Ngoungou, EB, Lemamy, GJ, Bisvigou, U, Gessain, A, Toure Ndouo, FS, Kazanji, M and Lekana-Douki, JB (2017) Non-malarial infectious diseases of antenatal care in pregnant women in Franceville, Gabon. BMC Pregnancy and Childbirth 17, 185.CrossRefGoogle Scholar
Murebwayire, E, Njanaake, K, Ngabonziza, JC, Jaoko, W and Njunwa, KJ (2017) Seroprevalence and risk factors of Toxoplasma gondii infection among pregnant women attending antenatal care in Kigali, Rwanda. Tanzania Journal of Health Research 19, 18.CrossRefGoogle Scholar
Nasir, IA, Aderinsayo, AH, Mele, HU and Aliyu, MM (2015) Prevalence and associated risk factors of Toxoplasma gondii antibodies among pregnant women attending Maiduguri Teaching Hospital, Nigeria. Journal of Medical Sciences 15, 147154.CrossRefGoogle Scholar
Ndiaye, D, Ndiaye, A, Sène, PD, Ndiaye, JL, Faye, B and Ndir, O (2007) Evaluation of serological tests of toxoplasmosis in pregnant women realized at the Laboratory of Parasitology and Mycology of Le Dantec Teaching Hospital in 2002. Dakar Medical 52, 5861.Google Scholar
Nicolle, C and Manceaux, LH (1908) Sur une infection a coyes de Leishman (ou organismes voisins) du gondi. CR Hebdomad Seance Academic Scientijique 147, 763766.Google Scholar
Oboro, IL, Obunge, OK and Wariso, KT (2016) Sero-epidemiology of toxoplasmosis among pregnant women in the University of Port Harcourt Teaching Hospital, Nigeria. Nigerian Health Journal 16, 112.Google Scholar
Ogouyèmi-Hounto, A, Agbayahoun-Chokki, F, Sissinto Savi de Tove, Y, Biokou, BB, Adinsi de Souza, V, Assogba, M, Kinde-Gazard, D and Massougbodji, A (2014) Evaluation of a rapid diagnostic test in the diagnosis of toxoplasmosis in pregnant women in Cotonou (Bénin). Bulletin de la Société de Pathologie Exotique 107, 8589.CrossRefGoogle Scholar
Olariu, TR, Remington, JS, McLeod, R, Alam, A and Montoya, JG (2011) Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants. Pediatric Infectious Disease Journal 30, 10561061.CrossRefGoogle ScholarPubMed
Olusi, T, Gross, U and Ajayi, J (1996) High incidence of toxoplasmosis during pregnancy in Nigeria. Scandinavian Journal of Infectious Diseases 28, 645646.CrossRefGoogle ScholarPubMed
Olusi, TA, Salawu, SA and Oniya, MO (2018) Seroepidemiology of toxoplasmosis among pregnant women in Osogbo, Southwestern, Nigeria. Journal of Infectious Diseases and Immunity 10, 816.Google Scholar
Onadeko, MO, Joynson, DH and Payne, RA (1992) The prevalence of Toxoplasma infection among pregnant women in Ibadan, Nigeria. Journal of Tropical Medicine and Hygiene 95, 143145.Google ScholarPubMed
Opsteegh, M, Kortbeek, TM, Havelaar, AH and van der Giessen, JW (2015) Intervention strategies to reduce human Toxoplasma gondii disease burden. Clinical Infectious Diseases 60, 101107.CrossRefGoogle ScholarPubMed
Pardini, L, Bernstein, M, Carral, LA, Kaufer, FJ, Dellarupe, A and Gos, ML (2019) Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina. Parasitology International 68, 4852.CrossRefGoogle ScholarPubMed
Paul, E, Kiwelu, I, Mmbaga, B, Nazareth, R, Sabuni, E, Maro, A, Ndaro, A, Halliday, JOE and Chilongola, J (2018) Toxoplasma gondii seroprevalence among pregnant women attending antenatal clinic in Northern Tanzania. Tropical Medicine and Health 46, 39.CrossRefGoogle ScholarPubMed
Pfaff, AW, Abou-Bacar, A, Letscher-Bru, V, Villard, O, Senegas, A, Mousli, M and Candolfi, E (2007) Cellular and molecular physiopathology of congenital toxoplasmosis: the dual role of IFN-gamma. Parasitology 134, 18951902.CrossRefGoogle ScholarPubMed
Prusa, AR, Kasper, DC, Pollak, A, Gleiss, A, Waldhoer, T and Hayde, M (2015) The Austrian toxoplasmosis register, 1992–2008. Clinical Infectious Diseases 60, e4e10.CrossRefGoogle ScholarPubMed
Remington, JS, McLeod, R, Thuilliez, P and Desmonts, G (2006) Toxoplasmosis. In Remington, JS, Klein, JO, Wilson, CB and Baker, C (eds), Infectious Diseases of the Fetus and Newborn Infant, 6th Edn. Philadelphia: Elsevier Saunders, pp. 9471091.CrossRefGoogle Scholar
Robbins, JR, Zeldovich, VB, Poukchanski, A, Boothroyd, JC and Bakardjiev, AI (2012) Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infection and Immunology 80, 418428.CrossRefGoogle ScholarPubMed
Robert-Gangneux, F and Dardé, ML (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clinical Microbiology Reviews 25, 264296.CrossRefGoogle ScholarPubMed
Rodier, MH, Berthonneau, J, Bourgoin, A, Giraudeau, G, Agius, G, Burucoa, C, Hekpazo, A and Jacquemin, JL (1995) Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. Acta Tropica 59, 271277.CrossRefGoogle ScholarPubMed
Rouatbi, M, Amairia, S, Amdouni, Y, Boussaadoun, MA, Ayadi, O, Al-Hosary, AA, Rekik, M, Ben Abdallah, R, Aoun, K, Darghouth, MA, Wieland, B and Gharbi, M (2019) Toxoplasma gondii infection and toxoplasmosis in North Africa: a review. Parasite 26, 6.CrossRefGoogle ScholarPubMed
Salawu, OT and Odaibo, AB (2013) Schistosomiasis among pregnant women in rural communities in Nigeria. International Journal of Gynaecology and Obstetrics 122, 14.CrossRefGoogle ScholarPubMed
Salawu, OT and Odaibo, AB (2014) Maternal schistosomiasis; a growing concern in sub-Saharan Africa. Pathogen and Global Health 108, 263270.CrossRefGoogle ScholarPubMed
Shiono, Y, Mun, HS, He, N, Nakazaki, Y, Fang, H, Furuya, M, Aosai, F and Yano, A (2007) Maternal-fetal transmission of Toxoplasma gondii in interferon-gamma deficient pregnant mice. Parasitology International 56, 141148.CrossRefGoogle ScholarPubMed
Silveira, C, Ferreira, R, Muccioli, C, Nussenblatt, R and Belfort, R Jr (2003) Toxoplasmosis transmitted to a newborn from the mother infected 20 years earlier. American Journal of Ophthalmology 136, 370371.CrossRefGoogle Scholar
Simpore, J, Savadogo, A, Ilboudo, D, Nadambega, MC, Esposito, M, Yara, J, Pignatelli, S, Pietra, V and Musumeci, S (2006) Toxoplasma gondii, HCV, and HBV seroprevalence and co-infection among HIV-positive and -negative pregnant women in Burkina Faso. Journal of Medical Virology 78, 730733.CrossRefGoogle ScholarPubMed
Sitoe, SP, Rafael, B, Meireles, LR, Andrade, HF Jr and Thompson, R. (2010) Preliminary report of HIV and Toxoplasma gondii occurrence in pregnant women from Mozambique. Revista Do Instituto de Medicina Tropical de São Paulo 52, 291295.CrossRefGoogle ScholarPubMed
Soares, JA and Caldeira, AP (2019) Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease. Revista da Sociedade Brasileira de Medicina Tropical 52, e20180228.CrossRefGoogle ScholarPubMed
Stray-Pedersen, B (1992) Treatment of toxoplasmosis in the pregnant mother and newborn child. Scandinavian Journal of Infectious Diseases 84, 2331.Google ScholarPubMed
Stray-Pedersen, B (1993) Toxoplasmosis in pregnancy. Baillière's Clinical Obstetrics and Gynaecology 7, 107137.CrossRefGoogle ScholarPubMed
Tenter, AM, Heckeroth, AR and Weiss, LM (2000) Toxoplasma gondii: from animals to humans. International Journal of Parasitology 30, 12171258.CrossRefGoogle Scholar
Tété-Bénissan, A, Doctorant, HM, Banla, AK, Balogou, A, Aklikokou, K and Gbeassor, M (2018) Seroprevalence and risk factors of toxoplasmosis in Togo. European Scientific Journal 14, 5669.CrossRefGoogle Scholar
Teweldemedhin, M, Gebremichael, A, Geberkirstos, G, Hadush, H, Gebrewahid, T, Asgedom, SW, Gidey, B, Asres, N and Gebreyesus, H (2019) Seroprevalence and risk factors of Toxoplasma gondii among pregnant women in Adwa district, northern Ethiopia. BMC Infectious Diseases 19, 327.CrossRefGoogle ScholarPubMed
The SYROCOT Study Group, Thiebaut, R, Leproust, S, Chene, G and Gilbert, RE (2007) Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet 369, 115122.Google ScholarPubMed
Todjom, FG, Tsapi, EM, Gamago, GA, Vignoles, P, Pone, JW and Teukeng, FF (2019) Seroprevalence of toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon. African Journal of Clinical and Experimental Microbiology 20, 221230.CrossRefGoogle Scholar
Torgerson, PR and Mastroiacovo, P (2013) The global burden of congenital toxoplasmosis: a systematic review. Bulletin of the World Health Organisation 91, 501508.CrossRefGoogle ScholarPubMed
Uttah, E, Ogban, E and Okonofua, C (2013) Toxoplasmosis: a global infection, so widespread, so neglected. International Journal of Scientific and Research Publications 3, 16.Google Scholar
Walle, F, Kebede, N, Tsegaye, A and Kassa, T (2013) Seroprevalence and risk factors for toxoplasmosis in HIV infected and non-infected individuals in Bahir Dar, Northwest Ethiopia. Parasites & Vectors 6, 15.CrossRefGoogle ScholarPubMed
Wallon, M, Peyron, F, Cornu, C, Vinault, S, Abrahamowicz, M, Kopp, CB and Binquet, C (2013) Congenital Toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years. Clinical Infectious Diseases 56, 12231231.CrossRefGoogle ScholarPubMed
Zemene, E, Yewhalaw, D, Abera, S, Belay, T, Samuel, A and Zeynudin, A (2012) Seroprevalence of Toxoplasma gondii and associated risk factors among pregnant women in Jimma town, Southwestern Ethiopia. BMC Infectious Diseases 12, 16.CrossRefGoogle ScholarPubMed