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The treatment of experimental cutaneous leishmaniasis with liposome-entrapped Pentostam

Published online by Cambridge University Press:  06 April 2009

R. R. C. New ,
M. L. Chance  and
S. Heath
R. R. C. New
Affiliation:
Department of Biochemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
M. L. Chance
Affiliation:
Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA
S. Heath
Affiliation:
Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA
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Summary

Treatment of cutaneous leishmaniasis by antimonial compounds when administered by various routes to mice infected with Leishmania major or L. mexicana amazonensis is enhanced, relative to the free drug, by entrapment of these compounds within liposomes. The efficacy of the liposome treatment is dependent on the time and route of administration, and upon the phospholipid composition of the liposomes themselves. Drug-loaded liposomes administered intravenously (i.v.) are more effective at reducing the growth of a cutaneous lesion if they are administered after the nodule has begun to develop, rather than at the time of inoculation of the parasites. In contrast to the i.v. route, liposomes administered subcutaneously (s.c.) at the inoculation site are only effective if given at the time of infection.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 3 , December 1981 , pp. 519 - 527
Copyright
Copyright © Cambridge University Press 1981

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References

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