Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-10T07:46:43.548Z Has data issue: false hasContentIssue false
  • English
  • Français

Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts

Published online by Cambridge University Press:  10 June 2015

Bridget M. Ogilvie
Bridget M. Ogilvie*
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
Get access Rights & Permissions [Opens in a new window]

Extract

Acquired resistance to some nematode parasites can be suppressed by daily administration of cortisone acetate to the host. Cortisone treatment completely suppressed previously acquired resistance of mice to Trichinella spiralis (Coker, 1956) and suppressed, at least partially, the acquisition of resistance to T. spiralis by rats during initial infection (Markell & Lewis, 1957).

A previous report (Weinstein, 1955) suggested cortisone acetate treatment was less effective in the suppression of acquired resistance of rats to Nippostrongylus brasiliensis. Weinstein showed that daily treatment with 2 mg cortisone acetate throughout five immunizing infections and continued during the challenge infection increased the number of worms in the intestine and had a marked effect on the cellular response in the skin and lungs. However, there was no significant effect when daily cortisone treatment commenced only on the fifth day before the challenge infection. This result suggested that acquisition of immunity to N. brasiliensis was partially overcome by cortisone treatment, but the same level of drug treatment had no effect on immunity already acquired.

In the experiments reported here, previously acquired resistance to N. brasiliensis was suppressed completely and the initiation of immunity stopped, either completely or at a very early stage, by treatment with the cortisone derivatives prednisolone or betamethasone. The complete suspension of all manifestations of acquired resistance obtained by treatment with these drugs was used to investigate the fate of larvae migrating in an immune host.

The rats and strain of parasite, and the methods of handling them, have been described previously (Ogilvie, 1965).

Type
Research Article
Information
Parasitology , Volume 55 , Issue 4 , November 1965 , pp. 723 - 730
Copyright
Copyright © Cambridge University Press 1965

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Asboe-Hansen, G. (1958). Hormonal effects on connective tissue. Physiol. Rev. 38, 446–62.CrossRefGoogle ScholarPubMed
Ashton, N. & Cook, C. (1952). In vivo observations of the effects of cortisone upon the blood vessels in rabbit ear chambers. Br. J. expl Path. 33, 445–50.Google Scholar
Berglund, K. (1962). Inhibition of antibody formation by prednisolone: location of a short sensitive period. Acta path. microbiol. scand. 55, 187–202.CrossRefGoogle ScholarPubMed
Coker, C. M. (1956). Some effects of cortisone in mice with acquired immunity to Trichinella spiralis. J. infect. Dis. 98, 39–44.CrossRefGoogle ScholarPubMed
Fischel, E. E., Stoerk, H. C. & Bjorneboe, M. (1951). Failure of cortisone to affect rate of disappearance of antibody protein. Proc. Soc. exp. Biol. Med. 77, 111–14.CrossRefGoogle ScholarPubMed
Gyllenstein, L. (1962). The cellular composition of lymphatic tissue during involution after administration of corticosteroid. Acta path. microbiol. scand. 56, 35–45.CrossRefGoogle Scholar
Kent, J. F., Baker, B. L., Ingle, D. J. & Li, C. H. (1954). Effect of corticotropin and cortisone on globule leucocytes of rat. Proc. Soc. exp. Biol. Med. 85, 635–7.CrossRefGoogle ScholarPubMed
Markell, E. K. & Lewis, W. P. (1957). Effect of cortisone treatment on immunity to subsequent reinfections with Trichinella in the rat. Am. J. trop. Med. Hyg. 6, 553–61.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1964 a). Nippostrongylus brasiliensis (Travassos. 1914; Travassos & Darriba, 1929). A study of the life cycle and the immunological response of the host. Dissertation, University of Cambridge, U.K.Google Scholar
Ogilvie, B. M. (1964 b). Reagin-like antibodies in animals immune to helminth parasites. Nature, Lond., 204, 91–2.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1965). Role of adult worms in immunity of rats to Nippostrongylus brasiliensis. Parasitology, 55, 325–35.CrossRefGoogle ScholarPubMed
Sarles, M. P. & Taliaferro, W. H. (1936). The local points of defence and the passive transfer of acquired immunity to Nippostrongylus muris in rats. J. infect. Dis. 59, 207–20.CrossRefGoogle Scholar
Sommerville, R. I. (1956). The histology of the ovine abomasum and the relation of the globule leucocyte to nematode infestations. Aust. vet. J. 32, 237–40.CrossRefGoogle Scholar
Taliaferro, W. H. & Sarles, M. P. (1939). The cellular reactions in the skin, lung and intestine of normal and immune rats after infection with Nippostrongylus muris. J. infect. Dis. 64, 157–92.CrossRefGoogle Scholar
Twohy, D. W. (1956). The early migration and growth of Nippostrongylus muris in the rat. Am. J. Hyg. 63, 165–85.Google ScholarPubMed
Weinstein, P. P. (1955). The effect of cortisone on the immune response of the white rat to Nippostrongylus muris. Am. J. trop. Med. Hyg. 41, 61–74.CrossRefGoogle Scholar
Wells, P. D. (1962). Mast cell, eosinophil and histamine levels in Nippostrongylus brasiliensis infected rats. Expl Parasit. 12, 82–101.CrossRefGoogle ScholarPubMed