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Quantum Indeterminism and Evolutionary Biology

Published online by Cambridge University Press:  01 April 2022

David N. Stamos
David N. Stamos*
Affiliation:
Department of Philosophy, York University
*
†Send requests for offprints to the author. Department of Philosophy, York University, Toronto, Ontario, Canada, M3J 1P3.
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Abstract

In “The Indeterministic Character of Evolutionary Theory: No ‘Hidden Variables Proof’ But No Room for Determinism Either,” Brandon and Carson (1996) argue that evolutionary theory is statistical because the processes it describes are fundamentally statistical. In “Is Indeterminism the Source of the Statistical Character of Evolutionary Theory?” Graves, Horan, and Rosenberg (1999) argue in reply that the processes of evolutionary biology are fundamentally deterministic and that the statistical character of evolutionary theory is explained by epistemological rather than ontological considerations. In this paper I focus on the topic of mutation. By focusing on some of the theory and research on this topic from early to late, I show how quantum indeterminism hooks up to point mutations (via tautomeric shifts, proton tunneling, and aqueous thermal motion). I conclude with a few thoughts on some of the wider implications of this topic.

Type
Research Article
Information
Philosophy of Science , Volume 68 , Issue 2 , June 2001 , pp. 164 - 184
Copyright
Copyright © 2001 by the Philosophy of Science Association

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Footnotes

‡

Thanks for helpful comments are due to two anonymous referees for Philosophy of Science and the following molecular biologists: John Drake, Jozef Kwiatkowski, Tom Martin, Ronald Pearlman, Thomas Schneider, R.C. von Borstel, Alan Weiner, and my late mentor Robert Haynes, with whom this paper should have been co-authored and to whose memory it is dedicated.

References

Brandon, Robert N., and Carson, Scott (1996), “The Indeterministic Character of Evolutionary Theory: No ‘Hidden Variables’ Proof But No Room for Indeterminism Either”, Philosophy of Science 63: 315–337.CrossRefGoogle Scholar
Chou, Shan-Ho, and Reid, Brian R. (1999), “DNA Mismatches in Solution”, in Neidle 1999, 331–353.Google Scholar
Doublié, Sylvie, and Ellenberger, Tom (1998), “The Mechanism of Action of T7 DNA Polymerase”, Current Opinion in Structural Biology 8: 704–712.CrossRefGoogle ScholarPubMed
Drake, John W. (1991), “Spontaneous Mutation”. Annual Review of Genetics 25: 125–146.CrossRefGoogle Scholar
Drake, John W., Glickman, Barry W., and Ripley, Lynn S. (1983), “Updating the Theory of Mutation”, American Scientist 71: 621–630, reprinted in Montgomery Slatkin (ed.) (1995), Exploring Evolutionary Biology: Readings from American Scientist. Sunderland: Sinauer Associates, 213–222.Google Scholar
Enz, Charles E. (1999), “The Science of Matter: Fascination and Limits”, in Atmanspacher, H., Amann, A., and Müller-Herold, U. (eds.), On Quanta, Mind and Matter. Dordrecht: Kluwer, 213–230.CrossRefGoogle Scholar
Evans, Timothy A., and Seddon, Kenneth R. (1997), “Hydrogen Bonding in DNA—A Return to the Status Quo”, Chemical Communications 21: 2023–2024.CrossRefGoogle Scholar
Fagan, Patricia A., et al. (1996), “NMR Study of the Conformation of the 2-Aminopurine:Cytosine Mismatch in DNA”, Biochemistry 35: 4026–4033.CrossRefGoogle ScholarPubMed
Fardella, Carlos E., et al. (1994), “Point Mutation of Arg440 to His in Cytochrome P450c17 Causes Severe 17α-Hydroxylase Deficiency,” Journal of Clinical Endocrinology and Metabolism 79: 160–164.Google Scholar
Fazakerley, G. Victor, Gdaniec, Zofia, and Sowers, Lawrence C. (1993), “Base-pair Induced Shifts in the Tautomeric Equilibrium of a Modified DNA Base”, Journal of Molecular Biology 230: 6–10.CrossRefGoogle ScholarPubMed
Florián, Jan, and Leszczyński, Jerzy (1996), “Spontaneous DNA Mutations Induced by Proton Transfer in the Guanine-Cytosine Base Pairs: An Energetic Perspective”, Journal of the American Chemical Society 118: 3010–3017.10.1021/ja951983gCrossRefGoogle Scholar
Freeman, Scott, and Herron, Jon C. (1998), Evolutionary Analysis. Upper Saddle River: Prentice Hall.Google Scholar
Futuyma, Douglas (1998), Evolutionary Biology. 3d ed. Sunderland: Sinauer Associates.Google Scholar
Glickman, Barry (1987), “The Gene Seemed as Inaccessible as the Materials of the Galaxies”, in Robson 1987, 33–57.Google Scholar
Goodman, Myron F. (1999), “On the Wagon—DNA Polymerase Joins ‘H-Bonds Anonymous‘”, Nature Biotechnology 17: 640–641.CrossRefGoogle Scholar
Graur, Dan, and Li, Wen-Hsiung (2000), Fundamentals of Molecular Evolution. 2d ed. Sunderland: Sinauer Associates.Google Scholar
Graves, Leslie, Horan, Barbara L., and Rosenberg, Alex (1999), “Is Indeterminism the Source of the Statistical Character of Evolutionary Theory?”, Philosophy of Science 66: 140–157.CrossRefGoogle Scholar
Haynes, Robert H. (1987), “The ‘Purpose’ of Chance in Light of the Physical Basis of Evolution.” in Robson 1987, 1–31.Google Scholar
Heisenberg, Werner (1989), Encounters with Einstein. Princeton: Princeton University Press.Google Scholar
Horan, Barbara L. (1994), “The Statistical Character of Evolutionary Theory”, Philosophy of Science 61: 76–95.CrossRefGoogle Scholar
Hunter, William N., and Brown, Tom (1999), “Single-Crystal X-ray Diffraction Studies on the Non-Watson-Crick Base Associations of Mismatches, Modified Bases, and Non-Duplex Oligonucleotide Structure”, in Neidle 1999, 313–330.Google Scholar
Johnson, Horton A. (1987), “Thermal Noise and Biological Information”, The Quarterly Review of Biology 62: 141–152.CrossRefGoogle ScholarPubMed
Kohen, Amnon, and Klinman, Judith P. (1999), “Hydrogen Tunneling in Biology”, Chemistry & Biology 6: R191–R198.CrossRefGoogle ScholarPubMed
Kwiatkowski, Jozef S., Zielinski, Theresa Julia, and Rein, Robert (1986), “Quantum-Mechanical Prediction of Tautomeric Equilibria”, Advances in Quantum Chemistry 18: 85–130.CrossRefGoogle Scholar
Lavery, Richard, and Zakrzewska, Krystyna (1999), “Base and Base Pair Morphologies, Helical Parameters, and Definitions”, in Neidle 1999, 39–76.Google Scholar
Löwdin, Per-Olov (1965), “Quantum Genetics and the Aperiodic Solid: Some Aspects of the Biological Problems of Heredity, Mutations, Aging, and Tumors in View of the Quantum Theory of the DNA Molecule”, Advances in Quantum Chemistry 2: 213–360.CrossRefGoogle Scholar
Löwdin, Per-Olov (1969), “Some Aspects of the Hydrogen Bond in Molecular Biology”, Annals of the New York Academy of Sciences 158: 87–95.CrossRefGoogle ScholarPubMed
Martin, T.W., and Derewenda, Zygmunt (1999), “The Name is Bond—H Bond”, Nature Structural Biology 1999: 403–406.10.1038/8195CrossRefGoogle Scholar
Monod, Jacques (1971), Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology. New York: Alfred A. Knopf.Google Scholar
Moran, Sean, Rex, X.-F. Ren, and Kool, Eric T. (1997), “Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication”, Journal of the American Chemical Society 119: 2056–2057.CrossRefGoogle ScholarPubMed
Neidle, Stephen (ed.) (1999), Oxford Handbook of Nucleic Acid Structure. Oxford: Oxford University Press.Google Scholar
Poltev, V. I., et al. (1996), “Modeling DNA Hydration: Comparison of Calculated and Experimental Hydration Properties of Nucleic Acid Bases”, Journal of Biomolecular Structure & Dynamics 13: 717–725.CrossRefGoogle Scholar
Pugliano, N., and Saykally, R. J. (1992), “Measurement of the vs Intermolecular Vibration of (D2O)2 by Tunable Far Infrared Laser Spectroscopy”, Journal of Chemical Physics 96: 1832–1839.CrossRefGoogle Scholar
Pugliano, N., and Saykally, R. J. (1993), “Measurement of Quantum Tunneling Between Chiral Isomers of the Cyclic Water Trimer”, Science 257: 1937–1940.CrossRefGoogle Scholar
Reanney, D. C., and Pressing, J. (1984), “Temperature as a Determinative Factor in the Evolution of Genetic Systems”, Journal of Molecular Evolution 21: 72–75.CrossRefGoogle ScholarPubMed
Robinson, Howard, et al. (1998), “2′-Deoxyisoguanosine Adopts More than One Tautomer To Form Base Pairs with Thymidine Observed by High-Resolution Crystal Structure Analysis”, Biochemistry 37: 10897–10905.CrossRefGoogle ScholarPubMed
Robson, John M. (ed.) (1987), Origin and Evolution of the Universe: Evidence for Design? Kingston and Montreal: McGill-Queen's University Press.Google Scholar
Rohrlich, Fritz (1983), “Facing Quantum Mechanical Reality”, Science 23: 1251–1255.CrossRefGoogle Scholar
Rosenberg, Alex (1988), “Is the Theory of Natural Selection a Statistical Theory?”, Canadian Journal of Philosophy (Suppl.) 14: 187–207.Google Scholar
Rosenberg, Alex (1994), Instrumental Biology, or the Disunity of Science. Chicago: University of Chicago Press.Google Scholar
Schrödinger, Erwin (1944), What is Life? Cambridge: Cambridge University Press, reprinted (1992).Google Scholar
Stamos, David N. (2001), “God and Evolutionary Biology?”, manuscript.Google Scholar
Suen, Wu, et al. (1999), “Identification by UV Resonance Raman Spectroscopy of an Imino Tautomer of 5-Hydroxy-2′-Deoxycytidine, a Powerful Base Analog Transition Mutagen with a Much Higher Unfavored Tautomer Frequency than that of the Natural Residue 2′-Deoxycytidine”, Proceedings of the National Academy of Sciences of the United States of America 96: 4500–4505.CrossRefGoogle ScholarPubMed
Tuckerman, Mark E., et al. (1997), “On the Quantum Nature of the Shared Proton in Hydrogen Bonds”, Science 275: 817–820.CrossRefGoogle ScholarPubMed
von Borstel, R. C. (1994), “Origins of Spontaneous Base Substitutions”, Mutation Research 307: 131–140.CrossRefGoogle ScholarPubMed
Watson, James D., and Crick, Francis H. (1953), “The Structure of DNA”, Cold Spring Harbor Symposia on Quantitative Biology 18: 123–131, reprinted in Gunther S. Stent (ed.) (1980), The Double Helix. New York: W.W. Norton & Company, 257–274.Google Scholar
Watson, James D., et al. (1987), Molecular Biology of the Gene. 4th ed. Menlo Park: Benjamin/Cummings.Google Scholar
Weinberg, Steven (1994), Dreams of a Final Theory. New York. Vintage Books.CrossRefGoogle Scholar