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X-ray powder diffraction analysis of ±-fenoprofen calcium dihydrate

Published online by Cambridge University Press:  05 March 2012

Ailette Aguila Tobien  and
Peter Varlashkin
Ailette Aguila Tobien
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709
Peter Varlashkin*
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709
*
a)Author to whom correspondence should be addressed; electronic mail: Peter.G.Varlashkin@gsk.com
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Abstract

The current JCPDS powder pattern for the racemic compound fenoprofen calcium dihydrate (card No. 44-1790) is unindexed. Previously we reported the single crystal data, determined at −100 °C, for this material (Zhu et al., 2001). Using 2θ values obtained from a powder pattern spiked with internal standards, we indexed the room temperature powder pattern. The resulting unit cell values for the monoclinic P21/n cell are a=19.018 Å, b=7.738 Å, c=19.472 Å, β=91.66°.

Keywords

fenoprofen calciumpowder X-ray patternpowder X-ray diffraction
Type
New Diffraction Data
Information
Powder Diffraction , Volume 17 , Issue 3 , September 2002 , pp. 244 - 246
Copyright
Copyright © Cambridge University Press 2002

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References

Bernstein, J. and Zevin, L. (1993). JCPDS card 44-1790.Google Scholar
Florey, K., editor (1977). Analytical Profiles of Substances and Excipients (Academic, New York), Vol. 6, pp. 161–182.Google Scholar
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Zhu, H., Xu, J., Varlashkin, P., Long, S., and Kidd, C. (2001). “Dehydration, hydration behavior, and structural analysis of fenoprofen calcium,” J. Pharm. Sci. JPMSAE 90, 845–859. jmk, JPMSAE CrossRefGoogle ScholarPubMed