Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-26T09:01:05.157Z Has data issue: false hasContentIssue false
  • English
  • Français

X-ray powder diffraction analysis of imipenem monohydrate

Published online by Cambridge University Press:  03 April 2012

F. Needham ,
C. E. Crowder ,
J. W. Reid ,
T. G. Fawcett  and
J. Faber
F. Needham*
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
C. E. Crowder
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
J. W. Reid
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
T. G. Fawcett
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
J. Faber
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
*
a)Author to whom correspondence should be addressed. Electronic mail: needham@icdd.com
Get access Rights & Permissions [Opens in a new window]

Abstract

An experimental X-ray powder diffraction pattern was produced and analyzed for imipenem monohydrate, an antimicrobial pharmaceutical agent. Although there are no experimental powder patterns in the ICDD PDF-4/Organics Database, there is one powder pattern calculated with single-crystal X-ray diffraction data from the Cambridge Structural Database. Here, we report the refined experimental powder diffraction data for imipenem monohydrate. These data for imipenem monohydrate are consistent with an orthorhombic crystal system having reduced unit-cell parameters of a = 8.2534(3) Å, b = 11.1293(4) Å, and c = 15.4609(6) Å. The resulting unit-cell volume, 1420.15(15) Å3, indicates four formula units per unit cell. Observed peaks are consistent with the P212121 space group.

Keywords

imipenemC12H17N3O4SX-ray powder diffractionβ-lactamhydrogen bonding
Type
Technical Articles
Information
Powder Diffraction , Volume 27 , Issue 1 , March 2012 , pp. 20 - 24
Copyright
Copyright © International Centre for Diffraction Data 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

ICDD (2011). PDF-4/Organics 2012 Database, edited by Kabekkodu, S., International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA.Google Scholar
Needham, F., Faber, J., and Fawcett, T. (2006). “X-ray powder diffraction analysis of tegafur,” Powder Diffr. J. 21(3), 245–247.CrossRefGoogle Scholar
Needham, F. and Faber, J. (2003). “Total pattern analysis using the new organic powder diffraction file: PDF-4/Organics,” Am. Pharm. Rev. 6(4), 10–12.Google Scholar
PANalytical (2011). HighScore Plus, Version 3.0.3 (Computer Software), PANalytical, Netherlands.Google Scholar
Ratcliffe, R., Wildonger, K., Michele, L., Douglas, A., Hajdu, R., Goegelman, R., Springer, J., and Hirshfield, J. (1989). “Studies on the structures of imipenem, dehydropeptidase I hydrolyzed imipenem, and related analogues,” J. Org. Chem. 54, 653–660.CrossRefGoogle Scholar
Sagnella, D. (2011). SQLAids (Computer Software), International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA.Google Scholar
Von Dreele, R. and Larson, A. (2001). General Structure Analysis System (GSAS, Computer Software), University of California, USA.Google Scholar