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Powder X-ray diffraction of 3,3-dichloro-1-(4-nitrophenyl)-2-piperidinone, C11H10Cl2N2O3

Published online by Cambridge University Press:  12 August 2015

Qing Wang ,
Ying Xiao ,
Jia Wei He  and
Hui Li
Qing Wang
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Ying Xiao
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Jia Wei He
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Hui Li*
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
*
a)Author to whom correspondence should be addressed. Electronic mail: lihuilab@sina.com
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Abstract

X-ray powder diffraction data for 3,3-dichloro-1-(4-nitrophenyl)-2-piperidinone, C11H10Cl2N2O3, are reported [a = 11.088(4) Å, b = 11.594(5) Å, c = 12.689(3) Å, α = 118.456(1)°, β = 100.320(3)°, γ = 107.763(3)°, V = 1259.27 Å3, Z = 4 and space group P-1 ]. All measured lines were indexed and are consistent with the P-1 space group. No detectable impurities were observed.

Keywords

3,3-dichloro-1-(4-nitrophenyl)-2-piperidinonepharmaceutical intermediateanticoagulantApixaban
Type
Rapid Communication
Information
Powder Diffraction , Volume 30 , Issue 3 , September 2015 , pp. 293
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Copyright
Copyright © International Centre for Diffraction Data 2015 

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References

Boultif, A. and Louër, D. (1991). “Indexing of powder diffraction patterns for low-symmetry lattices by the successive dichotomy method”, J. Appl. Crystallogr. 24, 987993.Google Scholar
de Wolff, P. M. (1968). “A simplified criterion for the reliability of a powder pattern”, J. Appl. Crystallogr. 1, 108–113.Google Scholar
Jiang, J. and Ji, Y. (2013). “Alternate synthesis of apixaban (BMS-562247), an inhibitor of blood coagulation factor Xa”, Synth. Commun. 43(1), 72–79.Google Scholar
Pawley, G. S. (1981). “Unit-cell refinement from powder diffraction scans”, J. Appl. Crystallogr. 14(6), 357–361.CrossRefGoogle Scholar
Smith, G. S. and Snyder, R. L. (1979). “FN: a criterion for rating powder diffraction patterns and evaluating the reliability of powder indexing,” J. Appl. Crystallogr. 12, 60–65.Google Scholar
Zikria, J. and Ansell, J. (2009). “Oral anticoagulation with factor Xa and thrombin inhibitors: is there an alternative to warfarin?” Discov. Med. 8(43), 196–203.Google Scholar
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