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Single-crystal structure analysis of designer drugs circulating in the Japanese drug market by the synchrotron radiation X-ray diffraction

Published online by Cambridge University Press:  20 June 2017

Takashi Hashimoto ,
Ruri Hanajiri ,
Nobuhiro Yasuda ,
Yuki Nakamura ,
Nobuhiro Mizuno ,
Sadao Honda ,
Shinjiro Hayakawa ,
Yoshinori Nishiwaki  and
Shigeru Kimura
Takashi Hashimoto*
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan
Ruri Hanajiri
Affiliation:
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Nobuhiro Yasuda
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Yuki Nakamura
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Nobuhiro Mizuno
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Sadao Honda
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Shinjiro Hayakawa
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan Faculty of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima-shi, Hiroshima 739-8527, Japan
Yoshinori Nishiwaki
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan Faculty of Education, Kochi University, 2-5-1 Akebono-cho, Kochi 780-8520, Japan
Shigeru Kimura
Affiliation:
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
*
a)Author to whom correspondence should be addressed. Electronic mail: thashimoto@spring8.or.jp
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Abstract

Over the past 20 years, many designer drugs derived from controlled substances have been widely distributed as easily available psychoactive substances and have become a serious problem in Japan. In order to determine the absolute structures of four new designer drugs derived from medicines (methylphenidate and phenmetrazine) X-ray single-crystal structure analyses were performed using the BL26B1 beamline of synchrotron radiation facility SPring-8. The results show that the molecular configuration of these designer drugs (having two asymmetric carbons), which were distributed in the illegal drug market had threo-forms as found for methylphenidate and phenmetrazine.

Keywords

synchrotron XRDdesigner drugs
Type
Technical Articles
Information
Powder Diffraction , Volume 32 , Issue 2 , June 2017 , pp. 112 - 117
Copyright
Copyright © International Centre for Diffraction Data 2017 

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References

EMCDDA (2015) EMCDDA – Europol 2015 Annual Report on the Implementation of Council Decision 2005/387/JHA.Google Scholar
Hashimoto, T., Honda, S., Yasuda, N., Kimura, S., Hayakawa, S., Nishiwaki, Y., and Takata, M. (2015) “Single-crystal structure analysis of drug powder sample by synchrotron radiation microbeam X-ray,” Adv. X-ray Anal. 59, 169.Google Scholar
Sheldrick, G. M. (2008). “A short history of SHELX,” Acta Crystallogr. A64, 112.Google Scholar
Ueno, G., Kanda, H., Hirose, R., Ida, K., Kumasaka, T., and Yamamoto, M. (2006) “RIKEN structural genomics beamlines at the SPring-8; high throughput protein crystallography with automated beamline operation,” J. Struct. Funct. Genomics 7, 15.CrossRefGoogle ScholarPubMed