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Adenosine for the Treatment of PSVT in the Prehospital Arena: Efficacy of an Initial 6 mg Dosing Regimen

Published online by Cambridge University Press:  28 June 2012

Lynn K. Wittwer  and
Marc D. Muhr
Lynn K. Wittwer*
Affiliation:
Medical Program Director, Clark County EMS, Vancouver WA; Director, Department of Emergency Medicine,Southwest Washington Medical Center, Vancouver, Washington, USA
Marc D. Muhr
Affiliation:
Assistant to the Medical Program Director, Clark County EMS, Vancouver, Washington, USA
*
Medical Program Director Clark County EMS PO Box 1600 Vancouver, WA 98668USA
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Abstract

Objective:

To confirm the efficacy of pre-hospital administration of adenosine, using a 6 milligram (mg) initial dosing regimen, for the treatment of paroxysmal supraventricular tachycardia (PSVT).

Methods:

Urban, suburban, rural emergency medical services (EMS) system in Clark County, Washington with advanced life support (ALS) patient transports. Concurrent, paramedic Medical Incident Report (MIR) review was conducted for 102 patients receiving prehospital adenosine during a 42-month period. Patients were administered 6 mg of adenosine using an intravenous (IV) bolus followed by 10 ml of balanced salt solution flush. If the patient's rhythm remained unchanged, the dosing regimen was increased to 12 mg followed by a 10 ml flush. This was repeated once more if the rhythm remained unchanged, to a total maximum dose of 30 mg. Medical direction for administration of adenosine was in the form of standing orders rather than direct (on-line) medical control.

Results:

Seventy-four of 102 patients had PSVT as determined by physician analysis of the initial six-second electrocardiographic rhythm strip (ECG) recording. Sixty-six of these patients converted their cardiac rhythm from PSVT using adenosine; 46 (70%) converted with the initial 6 mg bolus. Fifteen patients converted after receiving the second dose (12 mg); and five patients required 30 mg.

Conclusion:

These results show that for paramedics, adenosine is an effective treatment for PSVT. An initial bolus of 6 mg converts the majority of cases. Eighty-nine percent of cases of confirmed PSVT converted with adenosine administration.

Keywords

adenosinecardioconversionparamedicprehospitalPSVTstanding orderssupraventiclar tachycardiatachycardia
Type
Brief Report
Information
Prehospital and Disaster Medicine , Volume 12 , Issue 3 , September 1997 , pp. 64 - 66
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1997

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References

1. Griffith, M, Linker, N, Ward, D, et al: Adenosine in the diagnosis of broad complex tachycardia. Lancet 1988;1(8587) 672–675.CrossRefGoogle ScholarPubMed
2. Clarke, B, Rowland, E, Barnes, P, et al: Rapid and safe termination of supraventricular tachycardia in children by adenosine. Lancet 1987;1(8528):299–300.CrossRefGoogle ScholarPubMed
3. Sharma, A, Klein, G, Yee, R: Intravenous adenosine triphosphate during wide QRS complex tachycardia: Safety, therapeutic efficacy, and diagnostic utility. Am J Med 1990;88:337–343.CrossRefGoogle ScholarPubMed
4. Gausche, M, Persse, D, Sugarman, T, et al: Adenosine for the prehospital treatment of paroxysmal supraventricular tachycardia. Ann Emerg Med 1994;24:183–188.CrossRefGoogle ScholarPubMed
5. Cairns, CB, Niemann, JT: Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia. Ann Emerg Med 1991,20:717–721.CrossRefGoogle ScholarPubMed
6. American Heart Association: Textbook of Advanced Cardiac Life Support. American Heart Association: Dallas, Texas. 1994, p 40.Google Scholar
7. Furlong, R, Gerhardt, R, Farber, P, et al: Intravenous adenosine as first-line prehospital management of narrow-complex tachycardias by EMS personnel without direct physician control. Am J Emerg Med 1995;13:383–388.CrossRefGoogle ScholarPubMed
8. McCabe, J, Adhar, G, Menegazzi, J, et al: Intravenous adenosine in the prehospital treatment of paroxysmal supraventricular tachycardia. Ann Emerg Med 1992;21:358–361.CrossRefGoogle ScholarPubMed
9. DiMarco, J, Sellers, T, Lerman, B, et al: Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarhythmias. JACC 1985;6:417–425.CrossRefGoogle Scholar