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Effect of Methylprednisolone and Reduced Glutathione on Survival in Mice and Hepatic Energy Metabolism in Rats with Endotoxin Shock

Published online by Cambridge University Press:  17 February 2017

I. Kosugi ,
K. Tajimi  and
K. Okada
I. Kosugi
Affiliation:
Department of Anesthesiology, Teikyo University School of Medicine, Tokyo 173, Japan
K. Tajimi
Affiliation:
Department of Anesthesiology, Teikyo University School of Medicine, Tokyo 173, Japan
K. Okada
Affiliation:
Department of Anesthesiology, Teikyo University School of Medicine, Tokyo 173, Japan
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Extract

Reduced glytathione (GSH) is the tripeptide of glycine, cysteine and glutamic acid and is widely distributed in the body. FSH has been reported to comprise at least 90% of the nonprotein sulfhydryl (NPSH). Although the role of GSH in the tissue has not been clearly established, it is known to be a cofactor for enzymes, a substrate in detoxifications, and a free radical scavenger.

Several investigators have reported that the level of NPSH, mainly GSH, in the tissue was decreased in several types of shock and that exogenous administration of GSH has beneficial effects on shock (1,2). This study was designed to evaluate the effects of GSH on the survival rate in mice and the hepatic energy metabolism in rats after administration of endotoxin. These results were compared with those of methylprednisolone sodium succinate (MP), since many investigators have reported that the large doses of glucocorticoid have beneficial effects in several types of shock in experimental animals and in man (3,4).

Type
Section Two—Clinical Topics
Information
Prehospital and Disaster Medicine , Volume 1 , Issue 3 , Fall 1985 , pp. 249 - 251
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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References

1 Beck, LV, et al. Effects of tumbling, scalding and hemorrhage on rat tissue nonprotein sulfhydryl. Proc Soc Exptl Med 1963; 86:1358.Google Scholar
2 Galvin, JG, Lefer, AM. Salutary effects of cysteine on cardiogenic shock in cats. Am J Physiol 1978; 235:H657.Google ScholarPubMed
3 Kosugi, I, et al. Effect of reduced glutathione on oxygen affinity of hemoglobin in vitro and during canine hemorrhagic shock. Jap. J Anesthesiol 1979; 28:922.Google ScholarPubMed
4 Kosugi, I, et al. New approaches to shock therapy: reduced glutathione. (In press).Google Scholar
5 Schumer, WS. Steroids in the treatment of clinical septic shock. Ann Surg 1976; 184:333.CrossRefGoogle ScholarPubMed
6 Lillehei, RC, et al. Physiology and therapy of bacterial shock. Experimental and clinical observations. Am J Cardiol 1963; 13:599.CrossRefGoogle Scholar
7 Atkinson, DE. The energy charge of adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochem 1968; 7:4030.Google Scholar