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4. On the Changes produced by direct Chemical Addition on the Physiological Action of certain Poisons

Published online by Cambridge University Press:  15 September 2014

A. Crum Brown  and
Thomas R. Fraser
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Extract

In this paper the authors communicate the first results of an attempt to discover the relation which must exist between the chemical constitution and the physiological action of a substance. As the chemical constitution of the majority of physiologically active substances is unknown, they investigate the subject by examining the physiological action of a substance before and after the performance upon it of a definite chemical operation, introducing a known change into its constitution. The question is thus reduced to a problem in what may be called a chemico-physical calculus of finite variations.

Type
Proceedings 1867-68
Information
Proceedings of the Royal Society of Edinburgh , Volume 6 , 1869 , pp. 228 - 232
Copyright
Copyright © Royal Society of Edinburgh 1869

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References

page 230 note * The action of iodide of ethyl-strychnium was also examined, and found to be the same as that of iodide of methyl-strychnium.