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XIII.—Tests of Carcinogenic Substances in Relation to the Production of Mutations in Drosophila melanogaster

Published online by Cambridge University Press:  15 September 2014

Charlotte Auerbach
Charlotte Auerbach
Affiliation:
Institute of Animal Genetics, University of Edinburgh
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Extract

The theory has often been put forward that cancer is a somatic mutation. The changes which differentiate the cancerous cell from the normal are reproduced in many or all of the cells derived from the original malignant cell, i.e. they show the properties by which we define a mutation. Thus, to a geneticist, the possibility which most readily suggests itself is (1) that of a mutation in the genetic material of the somatic cell. Other possible mechanisms that might simulate the results of (1) are (2a) the introduction into the cell of a malignant virus; (2b) the “activation” of some such virus pre-existing in the cell in an inactive state, a situation which would imply mutation in the virus since the change becomes reproduced; (3) the production of some autocatalytic substance other than gene or virus, inducing malignant changes in the cell which contains a certain amount of it.

Type
Proceedings
Information
Proceedings of the Royal Society of Edinburgh , Volume 60 , Issue 2 , 1940 , pp. 164 - 173
Copyright
Copyright © Royal Society of Edinburgh 1940

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References

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