Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-27T09:51:44.441Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparative Neuropsychological Effects of Lamotrigine and Topiramate in Healthy Volunteers

Published online by Cambridge University Press:  13 June 2006

Kimford J. Meador
Kimford J. Meador
Affiliation:
Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Email: kimford.meador@neurology.ufl.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

anticonvulsantlamotriginetopiramatecognitionneuropsychology.
Type
Review Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 2 , Issue 1 , March 2007 , pp. 79 - 96
Copyright
© 2007 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abbetz, L., Jacoby, A., Baker, G.A., & McNulty, P. (2000). Patient based assessments of quality of life in newly diagnosed epilepsy patients: validation of the NEWQOL. Epilepsia, 41, 1119–1128.Google Scholar
Aldenkamp, A.P., Baker, G., Pieters, M.S., Schoemaker, H.C., Cohen, A.F., & Schwabe, S. (1995). The neurotoxicity scale: the validity of a patient-based scale assessing neurotoxicity. Epilepsy Research, 20, 229–239.Google Scholar
Aldenkamp, A.P., Baker, G., Mulder, O.G., et al. (2000). A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures. Epilepsia, 41, 1167–1178.Google Scholar
Aldenkamp, A.P., Arends, J., Bootsma, H.P., et al. (2002). Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers. Epilepsia, 43, 19–26.Google Scholar
Brodie, M.J., Richens, A., & Yuen, A.W.C. (1995). Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet, 345, 476–479.Google Scholar
Brodie, M.J., Overstall, P.W., Giorgi, L., & UK Lamotrigine Elderly Study Group (1999). Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Researh, 37, 81–87.Google Scholar
Burton, L.A., & Harden, C. (1997). Effect of topiramate on attention. Epilepsy Research, 27, 29–32.Google Scholar
Buschke, H., & Fuld, P.A. (1974). Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology, 24, 1019–1025.Google Scholar
Cohen, A.F., Ashby, L., Crowley, D., Land, G., Peck, A.W., & Miller, A.A. (1985). Lamotrigine (BW430C) potential anticonvulsant. Effects on the central nervous in comparison with phenytoin and diazepam. British Journal of Clinical Pharmacology, 29, 619–629.Google Scholar
Devinsky, O., Vickrey, B.G., Cramer, J., et al. (1995). Development of the quality of life in epilepsy (QOLIE) Inventory. Epilepsia, 36, 1089–1104.Google Scholar
Dodrill, C.B., Arnett, J.L., Sommerville, K.W., & Sussman, N.M. (1995). Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy. Epilepsia, 36, 164–173.Google Scholar
Dunn, L.M., & Dunn, L.M. (1997). Peabody Picture Vocabulary Test (3rd ed.). Circle Pines, MN: American Guidance Services.
Follett, P.L., Deng, W., Dai, W., Talos, D.M., Massillon, L.J., Rosenberg, P.A., Volpe, J.J., & Jensen, F.E. (2004). Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. Neurosci, 24, 4412–4420.Google Scholar
Fritz, N., Glogau, S., Hoffmann, J., Rademacher, M., Elger, C.E., & Helmstaedter, C. (2005). Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy and Behavior, 6, 373–381.Google Scholar
Gillham, R., Baker, G., Thompson, P., et al. (1996). Standardization of self-report questionnaire for use in evaluating cognitive, affective and behavioral side-effects of antiepileptic drug treatments. Epilepsy Research, 24, 47–55.Google Scholar
Gilliam, F. (2003). The impact of epilepsy on subjective health status. Current Neurology and Neuroscience Reports, 3, 357–362.Google Scholar
Glauser, T.A. (1999). Topiramate. Epilepsia, 40, S71–S80.Google Scholar
Glier, C., Dzietko, M., Bittigau, P., et al. (2004). Therapeutic doses of topiramate are not toxic to the developing rat brain. Experimental Neurology, 187, 403–409.Google Scholar
Golden, C.J. (1978). Stroop Color and Word Test. A Manual for Clinical and Experimental Uses. Chicago: Stoelting.
Hamilton, M.J., Cohen, A.F., Yuen, A.W.C., et al. (1993). Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosages. Epilepsia, 34, 166–173.Google Scholar
Henry, J.D., & Crawford, J.R. (2004). A meta-analytic review of verbal fluency performance following cortical lesions. Neuropsychology, 18, 284–295.Google Scholar
Jette, N.J., Marson, A.G., & Hutton, J.L. (2002). Topiramate add-on for drug-resistant partial epilepsy. Cochrane Database Systematic Reviews, 3, CD001417.Google Scholar
Kaplan, E., Goodglass, H. & Weintraub, S. (1983). The Boston Naming Test. Philadelphia: Lea & Febiger.
Lachman, R., Lachman, J.L., & Butterfield, E.C. (1979). Cognitive Psychology and Information Processing: An Introduction. Hillsdale, NJ: Lawrence Erlbaum.
LaRoche, S.M., & Helmers, S.L. (2004). The new antiepileptic drugs: scientific review. Journal of the American Medical Association, 291, 605–614.Google Scholar
Lee, Y.J., Ellenberg, J.H., Hirtz, D.G., & Nelson, K.B. (1991). Analysis of clinical trials by treatment actually received: is it really an option? Statistics in Medicine, 10, 1595–1605.Google Scholar
Lee, S., Sziklas, V., Andermann, F., et al. (2003a). The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia, 44, 339–347.Google Scholar
Lee, S., Sziklas, V., Andermann, F., et al. (2003b). The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia, 44, 339–347.Google Scholar
Lezak, M.D. (1995). Neuropsychological Assessment (3rd ed.). New York: Oxford University Press.
Loring, D.W., & Meador, K.J. (2004). Cognitive side effects of antiepileptic drugs in children. [Review]. Neurology, 62, 872–877.Google Scholar
Lorr, M., McNair, D.M., & Droppleman, L.F. (1971). Manual: Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service.
Martin, R., Kuzniecky, R., Ho, S., et al. (1999). Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology, 52, 321–327.Google Scholar
Meador, K.J. (1998). Cognitive and behavioral assessments in AED trials. Antiepileptic Drug Development. Advances in Neurology, 23, 231–237.Google Scholar
Meador, K.J. (2004a). Cognitive effects of epilepsy and of antiepileptic medications. In: Wyllie, E. (ed.), The Treatment of Epilepsy: Principles and Practice (4th ed.). Philadelphia: Lippincott Williams & Wilkins, pp. 1215–1226.
Meador, K.J. (2004b). Cognitive deficits from in utero AED exposure. Epilepsy Currents, 4, 196–197.Google Scholar
Meador, K.J., Loring, D.W., Allen, M.E., et al. (1991). Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology, 41, 1537–1540.Google Scholar
Meador, K.J., Loring, D.W., Abney, O.L., et al. (1993). Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia, 34, 153–115.Google Scholar
Meador, K.J., Loring, D.W., Moore, E.E., et al. (1995). Comparative cognitive effects of phenobarbital, phenytoin and valproate in healthy subjects. Neurology, 45, 1494–1499.Google Scholar
Meador, K.J., Loring, D.W., Ray, P.G., et al. (1999). Differential cognitive effects of carbamazepine and gabapentin. Epilepsia, 40, 1279–1285.Google Scholar
Meador, K.J., Loring, D.W., Ray, P.G., et al. (2001). Differential cognitive and behavioral effects of carbamazepine and lamotrigine. Neurology, 8, 1177–1182.Google Scholar
Meador, K.J., Loring, D.W., Hulihan, J.F., Kamin, M., & Karim, R. (2003). Differential cognitive and behavioral effects of topiramate and valproate. Neurology, 60, 1483–1488.Google Scholar
Meador, K.J., Loring, D.W., Vahle, V.J., Ray, P.G., Werz, M.A., Fessler, A.J., Ogrocki, P. Schoenberg, M.R., Miller, J.M., & Kustra, R.P. (2005). Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers. Neurology, 64, 2108–2115.Google Scholar
Perrine, K., Hermann, B.P., Meador, K.J., Vickrey, B.G., Cramer, J.A., Hays, R.D., & Devinsky, O. (1995). The relationship of neuropsychological functioning to quality of life in epilepsy. Archives of Neurology, 52, 997–1003.Google Scholar
Physicians' Desk Reference. (2005) (60th ed.). Montvale, NJ: Thomson PDR.
Ray, P.G., Meador, K.J., Loring, D.W., Zamrini, E.Y., Yang, X.H., & Buccafusco, J.J. (1992). Central anticholinergic hypersensitivity in aging. Journal of Geriatric Psychiatry and Neurology, 5, 72–77.Google Scholar
Rowan, A.J., Ramsay, R.E., Collins, J.F., Pryor, F., Boardman, K.D., Uthman, B.M., Spitz, M., Frederick, T., Towne, A., Carter, G.S., Marks, W., Felicetta, J., Tomyanovich, M.L., & VA Cooperative Study 428 Group. (2005). New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology, 64, 1868–1873.Google Scholar
Salinsky, M.C., Storzbach, D., Spencer, D.C., Oken, B.S., Landry, T., & Dodrill, C.B. (2005). Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers. Neurology, 64, 792–798.Google Scholar
Smith, A. (1973). Symbol Digit Modalities Test. Manual. Los Angeles: Western Psychological Services.
Smith, D., Baker, G., Davies, G., Dewey, M., & Chadwick, D.W. (1993). Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia, 34, 312–322.Google Scholar
Spreen, O., & Strauss, E. (1998). A Compendium of Neuropsychological Tests: Administration, Norms and Commentary. New York: Oxford University Press.
Steiner, T.J., Dellaportas, C.I., Findley, L.J., et al. (1999). Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. Epilepsia, 40, 601–607.Google Scholar
Thompson, P.J., Baxendale, S.A., & Duncan, J.S., Sander, J.W.A.S. (2000). Effects of topiramate on cognitive function. Journal of Neurology Neurosurgery and Psychiatry, 69, 636–641.Google Scholar
Ware, J.E., Kosinski, M., & Keller, S.D. (1996). A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Medical Care, 34, 220–233.Google Scholar
Zhao, Q., Hu, Y., & Holmes, G.L. (2005). Effect of topiramate on cognitive function and activity level following neonatal seizures. Epilepsy Behavior, 6, 529–536.Google Scholar