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Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease

Published online by Cambridge University Press:  08 June 2007

George J. Brewer ,
Fred Askari ,
Matthew T. Lorincz ,
Martha Carlson ,
Michael Schilsky ,
Karen J. Kluin ,
Peter Hedera ,
Paolo Moretti ,
John K. Fink  and
Roberta Tankanow
...Show all authors
George J. Brewer
Affiliation:
Department of Human Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Email: brewergj@umich.edu
Fred Askari
Affiliation:
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Email: faskari@med.umich.edu
Matthew T. Lorincz
Affiliation:
Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Email: lorincz@umich.edu
Martha Carlson
Affiliation:
Department of Pediatrics-Neurology, University of Michigan, Ann Arbor, MI, USA; Email: marthac@umich.edu
Michael Schilsky
Affiliation:
Department of Internal Medicine, Cornell University, New York, NY, USA; Email: mls2003@med.cornell.edu
Karen J. Kluin
Affiliation:
Department of Neurology, Department of Speech Pathology, University of Michigan, Ann Arbor, MI, USA; Email: niulk@umich.edu
Peter Hedera
Affiliation:
Department of Neurology, Vanderbilt University, Nashville, TN, USA; Email: peter.hedera@Vanderbilt.Edu
Paolo Moretti
Affiliation:
Departments of Neurology and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Email: pmoretti@bcm.tmc.edu
John K. Fink
Affiliation:
Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Email: jkfink@umich.edu
Roberta Tankanow
Affiliation:
College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; Email: robertat@umich.edu
Robert B. Dick
Affiliation:
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Email: bobdick@umich.edu
Julia Sitterly
Affiliation:
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Email: sitterly@umich.edu
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Extract

ABSTRACT

Background: The initial treatment of the neurologic presentation of Wilson's disease is problematic. Penicillamine, used for years on most patients, causes neurologic worsening in up to half of such patients, and half of those who worsen never recover. Zinc, ideal for maintenance therapy, is too slow for these acutely ill patients. We have developed tetrathiomolybdate (TM) for this type of patient, and it has worked well in open label studies. Trientine, another anticopper drug on the market approved for penicillamine intolerant patients, had not been tried in this type of patient. Here, we report on a double blind trial of TM versus trientine in the neurologically presenting Wilson's disease patient. Design and Methods: The study was a double blind design in which patients received either TM plus zinc, or trientine plus zinc, for 8 weeksThis study was originally published in reference 1. Patients were accepted if they presented with neurologic symptoms from Wilson's disease, if they had not been treated longer than 4 weeks with penicillamine or trientine. Patients were followed in the hospital for the 8 weeks of treatment with weekly semiquantitative neurologic and speech examinations, to evaluate possible neurologic worsening. They also had blood and urine studies done weekly. At discharge from hospital they were continued on zinc maintenance therapy, and returned at yearly intervals for 3 years for further evaluation. Results: Twenty-three patients were entered into the trientine arm and 6 reached criteria for neurologic deterioration, while 25 patients were entered into the TM arm and only 1 deteriorated (p < 0.05). One patient on trientine had an adverse event while 7 on TM had adverse events. All adverse events were mild. Four patients in the trientine arm died during follow-up, 3 having shown initial neurologic deterioration, 2 patients in the TM arm died. In those patients who did not deteriorate or die, neurologic and speech recovery over 3 years was good. Interpretation: TM is a superior choice to trientine for the initial therapy of neurologic Wilson's disease.

Keywords

copper toxicitydouble blind trialneurologic damagetetrathiomolybdatetrientineWilson's disease
Type
Research Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 3 , Issue 1 , January 2008 , pp. 153 - 165
Copyright
© 2008 Cambridge University Press

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