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Triflusal versus Aspirin for the Prevention of Stroke

Published online by Cambridge University Press:  18 December 2007

Antonio Culebras ,
Javier Borja  and
Julián García-Rafanell
Antonio Culebras
Affiliation:
Department of Neurology, Upstate Medical University, 750 E. Adams Street, Syracuse, NY 13210, USA; Email: aculebras@aol.com
Javier Borja
Affiliation:
Drug Safety Manager, J. Uriach y Compañía, S.A., Polígon Industrial Riera de Caldes, Avinguda Camí Reial, 51–57, 08184 Palau-solità i Plegamans, Barcelona, Spain; Email: fv-borja@uriach.com
Julián García-Rafanell
Affiliation:
Director of Medical Affairs, J. Uriach y Compañía, S.A., Polígon Industrial Riera de Caldes, Avinguda Camí Reial, 51–57, 08184 Palau-solità i Plegamans, Barcelona, Spain; Email: garcia-rafanell@uriach.com
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Extract

ABSTRACT

Antiplatelet agents represent an important part of the therapeutic armamentarium in the prevention of stroke. Triflusal is an antiplatelet agent structurally related to salicylates but not derived from acetylsalicylic acid. Like aspirin, triflusal irreversibly acetylates cyclo-oxygenase isoform 1 (COX-1) and therefore inhibits thromboxane biosynthesis. Triflusal is rapidly absorbed after oral administration, with an absorption half life of 0.44 hours. Evidence of the efficacy and safety of triflusal is derived from clinical trials performed in patients with unstable angina, acute myocardial infarction, stroke, aortocoronary by-pass, atrial fibrillation, valve replacement, and asthmatic patients intolerant to aspirin and/or non-steroidal antiinflamatory drugs (NSAID). The Triflusal versus Aspirin for the Prevention of Infarction: A Randomized Stroke Study (TAPIRSS) study was performed to explore the efficacy and safety of triflusal versus aspirin in the prevention of vascular complications in patients with a previous TIA or ischemic stroke in a Latin American population. In this pilot study differences between triflusal and aspirin in the prevention of vascular complications after TIA or ischemic stroke were not observed. Hemorrhagic risk was lower with triflusal than with aspirin. The TAPIRSS study contributed evidence on the efficacy and safety of triflusal as a valid alternative to aspirin in the prevention of vascular events in patients with ischemic stroke or TIA.

Keywords

antiplatelet agentaspirinstroketransient ischemic attacktriflusal.
Type
Research Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 3 , Issue 1 , January 2008 , pp. 13 - 33
Copyright
© 2008 Cambridge University Press

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