Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T16:33:23.455Z Has data issue: false hasContentIssue false
  • English
  • Français

Investigation of depot neuroleptic injection site reactions

Published online by Cambridge University Press:  02 January 2018

Julie C. Jones ,
Jennifer C. Day ,
John R. Taylor  and
Christopher S. Thomas
Julie C. Jones
Affiliation:
Department of Psychiatry, University Hospital of South Manchester, Manchester
Jennifer C. Day
Affiliation:
Department of Pharmaceutical Sciences, University of Nottingham, Nottingham
John R. Taylor
Affiliation:
North Mersey Community Trust, Sefton General Hospital, Liverpool
Christopher S. Thomas*
Affiliation:
Department of Psychiatry, University Hospital of South Manchester, Nell Lane, Manchester M20 8LR
*
∗Correspondence
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Aims and method

A cross-sectional survey was performed on 318 patients receiving depot medication. The presence or absence of a depot site reaction was recorded by psychiatric nursing staff on a standardised form.

Results

Seventeen per cent of patients were found to have clinically significant depot site reactions. Such reactions were associated with increased frequency of injection and increased total volume of depot administered in the previous 12 months. The severity of a depot site reaction was unrelated to the concentration of depot preparation administered.

Clinical implications

Depot site reactions may be reduced by maximising the interval between injections and using low volume (highly concentrated) preparations of depot neuroleptic medication.

Type
Original Papers
Information
Psychiatric Bulletin , Volume 22 , Issue 10 , October 1998 , pp. 605 - 607
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © 1998 The Royal College of Psychiatrists

References

Belanger-Annable, M. (1985) Long acting neuroleptics: technique for intramuscular injection. Canadian Nurse, 81, 1–3.Google Scholar
Davis, J. M. (1974) Dose equivalence of the anti-psychotic drugs. Journal of Psychiatric Research, 11, 66–69.Google Scholar
Foster, P. (1989) Neuroleptic equivalence. Pharmaceutical Journal, 243, 431–432.Google Scholar
Glazer, W. M. & Kane, J. M. (1992) Depot neuroleptic treatment: an underutilised treatment option. Journal of Clinical Psychiatry, 53, 426–533.Google Scholar
Gottfries, C. G. & Green, L. (1974) Flupenthixol decanoate in treatment of out-patients. Acta Psychiatrica Scandinavica, 255 (suppl.), 15–23.Google Scholar
Hamann, G. L., Egan, T. M., Wells, B. G., et al (1990) Injection site reactions after intramuscular administration of haloperidol decanoate 100 mg/ml. Journal of Clinical Psychiatry, 51, 502–504.Google Scholar
Hay, J. (1995) Complications at site of injection of depot neuroleptics. British Medical Journal 311, 421.Google Scholar
Hirsch, S. R., Gaind, R., Rohde, P. D., et al (1973) Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: Double blind placebo trial. British Medical Journal i 633–637.Google Scholar
McCreadie, R. G., Kiernan, W. E. S., Venner, R. M., et al (1979) Probable toxic necrosis after prolonged fluspirilene administration. British Medical Journal, 1, 523–524.CrossRefGoogle ScholarPubMed
Starmark, J., Forsman, A. & Wahlstrom, J. (1980) Abscesses following prolonged intramuscular administration of perphenazine enantate. Acta Psychiatrica Scandinavica, 62, 154–157.Google Scholar
Svendsen, O. (1989) Studies of Tissue Injuries Caused by Intramuscular Injection of Drugs and Vehicles . Methods for Quantification and Effects of Concentration, Volume, Vehicle, Injection Speed and Intralipomatous Injection. Copenhagen: Medicinsk-historisk Museum.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.