Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-10T12:08:10.314Z Has data issue: false hasContentIssue false
  • English
  • Français

Génétique et psychiatrie : une nouvelle approche de l’étiopathogénie des maladies mentales ?

Published online by Cambridge University Press:  28 April 2020

M. Leboyer  and
F. Clerget-Darpoux
M. Leboyer
Affiliation:
Unité de génétique épidémiologique, INSERM U 155, Château de Longchamp, Bois de Boulogne, 75016Paris, France
F. Clerget-Darpoux
Affiliation:
Unité de génétique épidémiologique, INSERM U 155, Château de Longchamp, Bois de Boulogne, 75016Paris, France

Résumé

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Jusqu’à présent, différentes méthodes ont été utilisées pour mettre en évidence l’influence de facteurs de risque d’origine génétique: comparaison du taux de concordance chez des jumeaux monozygotes et dizygotes, études d’adoption, analyse de ségrégation et analyse de linkage. Le développement explosif de la biologie moléculaire, fournissant un nombre grandissant de marqueurs génétiques, rend particulièrement prometteuse l’application des techniques de linkage. Néanmoins, il faut être conscient que l’application de cette stratégie aux maladies psychiatriques se heurte à des difficultés spécifiques: critères diagnostiques, âge de début variable, hétérogénéité probable, corrélations intrafamiliales environnementales.

Summary

Summary

Until recently, different methods have been used to show the role of risk factors in the etiopathology of psychiatric diseases: comparison of concordance rates of monozygote and dizygote twins, adoption studies, segregation analysis, linkage analysis. This last approach has become an exciting one with the growing number of genetic markers due to progress in molecular genetics. Nevertheless, we must be aware of the fact that linkage strategy applied to psychiatric disease has toface specific problems: diagnostic criteria, variable age of onset, possible heterogeneity, environmental intrafamilial correlations.

Keywords

génétiqueétiopathogénie des maladies mentalesgeneticsetiopathology of psychiatric diseases
Type
Editorial
Information
Psychiatry and Psychobiology , Volume 3 , Issue 2 , 1988 , pp. 69 - 72
Copyright
Copyright © European Psychiatric Association 1988

References

Références

Clerget-Darpoux, F.Bonaiti, C. & Hochez, J. (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics. 42, 393–399CrossRefGoogle ScholarPubMed
Egeland, J.Gerhard, D.S.Pauls, D.Sussex, J.N.Kidd, K.K.Allen, C.R.Hostetter, A.M. & Houseman, D.E. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature. 325, 783–787CrossRefGoogle ScholarPubMed
Goldin, L.R.Gershon, E.S.Targum, S.D. & McGinnis, M. (1983) Segregation and linkage analyses in families of patients with bipolar, unipolar, and schizoaffective mood disorders. Am. J. Hum. Genet. 35, 274–287Google ScholarPubMed
Goldin, L.R. & Gershon, E.S.The genetic epidemiology of major depressive illness. Am. Psychiatric Assoc. Annu. Rev. vol.7(in press)Google Scholar
McGue, M.Gottesman, I. & Rao, D. (1985) Resolving genetic models for the transmission of schizophrenia. Genet. Epidemiol. 2, 99–110CrossRefGoogle ScholarPubMed
Mallet, J. & Leboyer, M. (1987) Molecular genetics, bipolar disorders and the catecholamine hypothesis. Symposium, Biological Psychiatry TodayGoogle Scholar
Mendlewicz, J.Simon, P.Sevy, S.Charon, F.Brocas, H.Legros, S. & Vassart, G. (1987) Polymorphic DNA marker on X chromosome and manic depression. Lancet. 30, 1230–1231CrossRefGoogle Scholar
Risch, N. & Baron, M. (1982) X-linkage and genetic heterogeneity in bipolar-related major affective illness : reanalysis of linkage data. Ann. Hum. Genet. 46, 153–166CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.