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Induction of yawning by low doses of apomorphine (0.1, 0.2 and 0.4 mg) in healthy volunteers

Published online by Cambridge University Press:  28 April 2020

O. Blin ,
P. Danjou ,
D. Warot ,
J. Fondarai  and
A.J. Puech
O. Blin
Affiliation:
Clinique des Maladies Neuromusculaires, CHU Timone, 13005, Marseille
P. Danjou*
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, 47 Bd de l‘Hôpital, 75651Paris Cedex 13
D. Warot
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, 47 Bd de l‘Hôpital, 75651Paris Cedex 13
J. Fondarai
Affiliation:
Service de Statistique, ERACM, 232 Bd Ste-Marguerite, 13009Marseille, France
A.J. Puech
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, 47 Bd de l‘Hôpital, 75651Paris Cedex 13
*
*Correspondance and reprints
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Summary

The dopaminergic agonist apomorphine hydrochloride (0.1, 0.2 and 0.4 mg s.c.) compared to placebo in a double-blind, latin square design induced yawing in population of 8 healthy volunteers. Yawning was the only behavioral effect observed and was not dose-related, as all the 3 doses were equipotent. Yawning was maximum between 10 and 20 min post-injection and did not last longer than 20 min. Compared to the data in the literature, 0.1 mg is the lowest dose described as inducing yawning in man. Further studies using doses lower than 0.1 mg would be required to determine the highest inactive dose in order to use apomorphine-induced yawning as an index of CNS dopaminergic receptor sensitivity.

Résumé

Résumé

L'apomorphine, agoniste dopaminergique, administrée en sous-cutané à la dose de 0.1, 0.2 et 0.4 mg s.c., a entra— Baillements induits chez le volontaire sain par de faibles doses d’apomorphinené des baillements chez 8 volontaires sains, comparativement au placebo. Les baillements ont été les seuls effets comportementaux observés. Il n’existe pas de relation dose-effet aux trois doses étudiees mais les trois traitements sont differents du placebo entre la 10e et la 20e minute aprés l’injection. Des doses plus faibles seraient donc à étudier de maniére à se situer dans la zone de linéarité de la relation dose-effet, pour l’évaluation ultérieure de la sensibilité des systémes dopaminergiques centraux.

Keywords

apomorphineyawninghealthy volunteerdopamineapomorphinebaillementsvolontaires sainsdopamine
Type
Original article
Information
Psychiatry and Psychobiology , Volume 3 , Issue 3 , 1988 , pp. 195 - 199
Copyright
Copyright © European Psychiatric Association 1988

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References

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