Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-27T06:28:28.074Z Has data issue: false hasContentIssue false
  • English
  • Français

Sérotonine et dépression: psychopathologie dimensionnelle

Published online by Cambridge University Press:  28 April 2020

Y Lecrubier  and
P Aloupis
Y Lecrubier
Affiliation:
INSERM U 302, hôpital de la Salpêtrière, pavillon Clérambault, 47, bd de l ‘Hôpital, 75013Paris, France
P Aloupis
Affiliation:
INSERM U 302, hôpital de la Salpêtrière, pavillon Clérambault, 47, bd de l ‘Hôpital, 75013Paris, France
Get access

Résumé

L’approche nosologique - classique en psychiatrie - n’est plus pertinente pour la dépression. Des paramètres biologiques mettent en évidence l’existence de différentes dimensions dans cette pathologie, dont certaines, liées à des modifications du fonctionnement sérotoninergique, sont sensibles à des produits modifiant ce fonctionnement. Le fait que le traitement de patients obsessionnels par benzodiazépines apporte une amélioration de la symptomatologie anxieuse s’exprimant au niveau neurovégétatif mais a tendance à aggraver les obsessions donne à penser que le médicament reste un des meilleurs outils pour une identification pertinente de dimensions transnosologiques.

Summary

Summary

A nosographic approach, although classical in psychiatry, seems to no longer be relevant in the field of depression. In this kind of pathology, some biological dysfunctions are probably linked with particular behavioral dimensions. Among those dimensions certain ones seem to be modified by compounds active on the serotonergic (5HT) system, evidencing the relationships which can exist between SHT and a cluster of “depressive” symptoms. In a different way, benzodiazepines, if effective on peripheral anxious symptomatology in obsessive compulsive disorder (OCD), are frequently worsening obsessions themselves. Thus, it appears that psychoactive drugs are the best tools to identify the most relevant dimensions of psychopathology.

Keywords

sérotoninedépressionpsychopathologieserotonindepressionpsychopathology
Type
Article Original
Information
Psychiatry and Psychobiology , Volume 5 , Issue 3 , 1990 , pp. 219 - 223
Copyright
Copyright © European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Références

Asberg, M, Traskman, L, Thoren, P (1976) 5-H1AA in the Cerebrospinal Fluid: a Biochemical Suicide Predictor? Arch Gen Psychiatry, 33, 1193–1197CrossRefGoogle Scholar
Brown, GL, Goodwin, FK, Ballenger, JC, Goyer, PF, Major, LF (1979) Agression in Humans Correlates with Cerebrospinal Fluid Amine Metabolites. Psychiatr Res, 1, 131–139CrossRefGoogle Scholar
Coccaro, EM, Siever, LJ, Klar, M, Rubinstein, R, Moskovitz, A, Davis, KL (1986) 5-HT in Affective and Personality Disorders. In: Abstracts of the ACNP Congress, San Juan, Puerto RicoGoogle Scholar
Kaye, WH, Ebert, MH, Gwirtman, HE, Weirs, SR (1984) Differences in Brain Serotoninergic Metabolism between Non-Bulimic and Bulimic Patients with Anorexia Nervosa. Am J Psychiatry, 141, 1598–1601Google Scholar
Linnoila, M, Virkhumen, M, Scheinin, M, Nuutila, A, Rimon, R, Goodwin, FK (1983) Low Cerebrospinal Fluid 5-HIAA Concentration Differentiates Impulsive from Non-Impulsive Violent Behavior. Life Sci, 33, 2609–2614CrossRefGoogle Scholar
Lecrubier, Y (1988) Sérotonine et capacité à différer une conduite: un modèle psychobiologique. Psychiatr Psychobiol, 3, 95S–100SGoogle Scholar
Schalling, D, Asberg, M, Edman, G, Levander, S (1984) Impulsivity, Non Conformity and Sensation Seeking as Related to Biological Markers for Vulnerability. Clin Neuropharmacol, 7 (suppl 1), 746–747CrossRefGoogle Scholar
Van, Praag HM (1988a) Serotonin Disturbances in Psychiatrie Disorders: Functional versus Nosological Interpretation. Adv Biol Psychiatry 17, 52–57Google Scholar
Van, Praag HM (1988b) Serotoninergic Mechanisms and Suicidai Behavior. Psychiatr Psychobiol, 3, 335–346Google Scholar
Submit a response

Comments

No Comments have been published for this article.