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Reduced immunity to measles in adults with major depressive disorder

Published online by Cambridge University Press:  19 March 2018

Bart N. Ford Open the ORCID record for Bart N. Ford [Opens in a new window] ,
Robert H. Yolken ,
Faith B. Dickerson ,
T. Kent Teague ,
Michael R. Irwin ,
Martin P. Paulus  and
Jonathan Savitz
Bart N. Ford*
Affiliation:
Laureate Institute for Brain Research, Tulsa, OK, USA The University of Tulsa Department of Biological Sciences, Tulsa, OK, USA
Robert H. Yolken
Affiliation:
Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD, USA
Faith B. Dickerson
Affiliation:
Sheppard Pratt Health System, Baltimore, MD, USA
T. Kent Teague
Affiliation:
Departments of Surgery and Psychiatry, University of Oklahoma School of Community Medicine, Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA
Michael R. Irwin
Affiliation:
Cousins Center for Psychoneuroimmunology at UCLA, Semel Institute for Neuroscience and UCLA David Geffen School of Medicine, Los Angeles, CA, USA
Martin P. Paulus
Affiliation:
Laureate Institute for Brain Research, Tulsa, OK, USA
Jonathan Savitz
Affiliation:
Laureate Institute for Brain Research, Tulsa, OK, USA Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA
*
Author for correspondence: Bart Ford, E-mail: bford@laureateinstitute.org
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Abstract

Background

Depression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypothesis that individuals with adolescent or adult onset mood disorders would display compromised immunity to measles, a target of childhood vaccination.

Methods

IgG antibodies to measles were quantified using a solid phase immunoassay in volunteers with bipolar disorder (BD, n = 64, mean age of onset = 16.6 ± 5.6), currently depressed individuals with major depressive disorder (cMDD, n = 85, mean age of onset = 17.9 ± 7.0), remitted individuals with a history of MDD (rMDD, n = 82, mean age of onset = 19.2 ± 8.6), and non-depressed comparison controls (HC, n = 202), all born after the introduction of the measles vaccine in the USA in 1963.

Results

Relative to HC, both the cMDD group (p = 0.021, adjusted odds ratios (OR) = 0.47, confidence interval (CI) = 0.24–0.90), and the rMDD group (p = 0.038, adjusted OR = 0.50, CI = 0.26–0.97) were less likely to test seropositive for measles. Compared with unmedicated MDD participants, currently medicated MDD participants had a longer lifetime duration of illness and were less likely to test seropositive for measles.

Conclusions

Individuals with adolescent or adult onset MDD are less likely to test seropositive for measles. Because lower IgG titers are associated with increased risk of measles infection, MDD may increase the risk and severity of infection possibly because of impaired maintenance of vaccine-related protection from measles.

Keywords

Depressioninfectionmajor depressive disordermeaslesstressvaccine
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 2 , January 2019 , pp. 243 - 249
Copyright
Copyright © Cambridge University Press 2018 

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