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The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

Published online by Cambridge University Press:  20 April 2020

Lijuan Gao ,
Lihua Gu ,
Hao Shu ,
Jiu Chen ,
Jianli Zhu ,
Bi Wang ,
Yachen Shi ,
Ruize Song ,
Kun Li  and
Xianrui Li
...Show all authors
Lijuan Gao
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Lihua Gu
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Hao Shu
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Jiu Chen
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Jianli Zhu
Affiliation:
Department of Psychology, Xinxiang Medical University, Xinxiang, Henan453003, China
Bi Wang
Affiliation:
Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan453002, China
Yachen Shi
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Ruize Song
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China
Kun Li
Affiliation:
Department of Psychology, Xinxiang Medical University, Xinxiang, Henan453003, China
Xianrui Li
Affiliation:
Department of Psychology, Xinxiang Medical University, Xinxiang, Henan453003, China
Haisan Zhang
Affiliation:
Department of Radiology, Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan453002, China
Hongxing Zhang
Affiliation:
Department of Psychology, Xinxiang Medical University, Xinxiang, Henan453003, China
Zhijun Zhang*
Affiliation:
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu210009, China Department of Psychology, Xinxiang Medical University, Xinxiang, Henan453003, China
*
Author for correspondence: Zhijun Zhang, E-mail: janemengzhang@vip.163.com
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Abstract

Background

Amnestic mild cognitive impairment (aMCI) is characterized by delayed P300 latency and reduced grey matter (GM) volume, respectively. The relationship between the features in aMCI is unclear. This study was to investigate the relationship between the altered P300 latency and the GM volume in aMCI.

Methods

Thirty-four aMCI and 34 well-matched normal controls (NC) were studied using electroencephalogram during a visual oddball task and scanned with MRI. Both tests were finished in the same day.

Results

As compared with the NC group, the aMCI group exhibited delayed P300 latency in parietal cortex and reduced GM volumes in bilateral temporal pole and left hippocampus/parahippocampal gyrus. A remarkable negative correlation was found between delayed P300 latency and reduced left hippocampal volume only in the aMCI group. Interestingly, the mediating analysis found P300 latency significantly mediated the association between right supramarginal gyrus volume and information processing speed indicated by Stroop Color and Word Test A scores.

Conclusions

The association between delayed P300 latency and reduced left hippocampal volume in aMCI subjects suggests that reduced left hippocampal volume may be the potential structural basis of delayed P300 latency.

Keywords

Amnestic mild cognitive impairmentP300event-related potentialMRImediating effect
Type
Original Article
Information
Psychological Medicine , Volume 51 , Issue 12 , September 2021 , pp. 2054 - 2062
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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