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Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy

Published online by Cambridge University Press:  26 April 2017

B. Oranje ,
B. Aggernaes ,
H. Rasmussen ,
B. H. Ebdrup  and
B. Y. Glenthøj
B. Oranje*
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Services Glostrup, Capital Region Denmark, Glostrup, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
B. Aggernaes
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Services Glostrup, Capital Region Denmark, Glostrup, Denmark
H. Rasmussen
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Services Glostrup, Capital Region Denmark, Glostrup, Denmark
B. H. Ebdrup
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Services Glostrup, Capital Region Denmark, Glostrup, Denmark
B. Y. Glenthøj
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Services Glostrup, Capital Region Denmark, Glostrup, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
*
*Address for correspondence: B. Oranje, Ph.D., Center for Neuropsychiatric Schizophrenia Research, University Psychiatric Center Glostrup, Ndr. Ringvej 29-67, DK-2600 Glostrup, Denmark. (Email: B.Oranje@cnsr.dk)
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Abstract

Background

Attention deficits have been frequently reported in schizophrenia. It has been suggested that treatment with second-generation antipsychotics can ameliorate these deficits. In this study, the influence of 6 months treatment with quetiapine, a compound with less affinity for dopamine D2 receptors than for serotonergic 5-HT2A receptors, on electrophysiological parameters of attention was investigated in a group of antipsychotic-naïve, first-episode schizophrenia patients compared with a group of age- and gender-matched healthy controls.

Method

A total of 34 first-episode, antipsychotic-naïve patients with schizophrenia and an equal number of healthy controls were tested in a selective attention and a typical mismatch negativity (MMN) paradigm at baseline and after 6 months. The patients were treated with quetiapine according to their clinical needs during the period between baseline and follow-up, whereas controls received no treatment.

Results

Patients showed lower MMN and P200 amplitude than healthy controls in the selective attention paradigm at baseline, while this was not the case for MMN of the typical MMN paradigm. Interestingly, after 6 months treatment, this MMN deficit was only ameliorated in patients treated with above median dosages of quetiapine. Patients had lower P3B amplitude, yet showed similar levels of processing negativity and N100 amplitude compared with healthy controls, both at baseline and follow-up.

Conclusions

The results indicate that deficits in MMN, P200 and P3B amplitude are present at early stages of schizophrenia, although depending on the paradigm used. Furthermore, the results indicate that 6 months quetiapine treatment ameliorates MMN but not P3B deficits, and only in those subjects on higher dosages.

Keywords

Antipsychotic naïve first episode schizophreniaquetiapinemismatch negativityselective attentionelectrophysiology
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 12 , September 2017 , pp. 2155 - 2165
Copyright
Copyright © Cambridge University Press 2017 

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