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The acute and medium-term effects of treatment with electroconvulsive therapy on memory in patients with major depressive disorder

Published online by Cambridge University Press:  23 October 2015

N. P. Maric ,
Z. Stojanovic ,
S. Andric ,
I. Soldatovic ,
M. Dolic  and
Z. Spiric
N. P. Maric*
Affiliation:
School of Medicine, University of Belgrade, Dr Subotica 8, Belgrade, Serbia Clinic for Psychiatry Clinical Center of Serbia, Pasterova 2, Belgrade, Serbia
Z. Stojanovic
Affiliation:
Clinic for Psychiatry, Military Medical Academy, Belgrade, Serbia
S. Andric
Affiliation:
School of Medicine, University of Belgrade, Dr Subotica 8, Belgrade, Serbia
I. Soldatovic
Affiliation:
School of Medicine, University of Belgrade, Dr Subotica 8, Belgrade, Serbia
M. Dolic
Affiliation:
Clinic for Psychiatry, Military Medical Academy, Belgrade, Serbia
Z. Spiric
Affiliation:
Clinic for Psychiatry, Military Medical Academy, Belgrade, Serbia Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia
*
*Address for correspondence: N. P. Maric, MD, PhD, School of Medicine, University of Belgrade & Clinic for Psychiatry CCS, Pasterova 2, Belgrade 11000, Serbia. (Email: nadja.maric-bojovic@mfub.bg.ac.rs)
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Abstract

Background

Current literature provides insufficient information on the degree of cognitive impairment during and after electroconvulsive therapy (ECT), mostly due to the fact that applied tests lacked sensitivity and flexibility. Our goal was to evaluate cognitive functioning in adult depressed patients treated with bi-temporal ECT, using tests sensitive for detection of possible acute and medium-term memory changes.

Method

Thirty adult patients with major depressive disorder, treated with a course of bi-temporal ECT, underwent clinical and cognitive measurements three times: at baseline, immediately after a course of ECT, and 1 month later. For cognition assessment, we used learning and visual, spatial and figural memory tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).

Results

Bi-temporal ECT has proven to be an effective treatment. The linear mixed model, used to analyze changes in depression severity and patients’ cognitive performances over time and to assess dynamic correlations between aforementioned features, did not show any significant memory impairment as a potential acute or medium-term ECT effect. However, it yielded significant improvement on visual memory and learning at the follow-up, which positively correlated with the improvement of depression.

Conclusion

Good progress is being made in the search for ECT-related acute and medium-term cognitive side-effects by using the tests sensitive to detect memory dysfunction with parallel forms of the tasks (to counter practice effects on repeat testing). Our results on learning and memory in relation to ECT during treatment of depression did not bring forth any prolonged and significant bi-temporal ECT-related memory deficit.

Keywords

CANTABdepressionelectroconvulsive therapylearningmemory
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 4 , March 2016 , pp. 797 - 806
Copyright
Copyright © Cambridge University Press 2015 

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References

Abbott, CC, Gallegos, P, Rediske, N, Lemke, NT, Quinn, DK (2014). A review of longitudinal electroconvulsive therapy: neuroimaging investigations. Journal of Geriatric Psychiatry and Neurology 27, 33–46.Google Scholar
Adelstein, TB, Kesner, RP, Strassberg, DS (1992). Spatial recognition and spatial order memory in patients with dementia of the Alzheimer's type. Neuropsychologia 30, 59–67.CrossRefGoogle ScholarPubMed
Beall, EB, Malone, DA, Dale, RM, Muzina, DJ, Koenig, KA, Bhattacharrya, PK, Jones, SE, Phillips, MD, Lowe, MJ (2012). Effects of electroconvulsive therapy on brain functional activation and connectivity in depression. Journal of ECT 28, 234–241.CrossRefGoogle ScholarPubMed
Bolwig, TG (2014). Neuroimaging and electroconvulsive therapy: a review. Journal of ECT 30, 138–142.Google Scholar
de Jong, JO, Arts, B, Boks, MP, Sienaert, P, van den Hove, DL, Kenis, G, van os, J, Rutten, BP (2014). Epigenetic effects of electroconvulsive seizures. Journal of ECT 30, 152–159.CrossRefGoogle ScholarPubMed
Duff, K, Schoenberg, MR, Scott, JG, Adams, RL (2005). The relationship betweenexecutive functioning and verbal and visual learning and memory. Archives of Clinical Neuropsychology 20, 111–122.CrossRefGoogle ScholarPubMed
Egerhazi, A, Balla, P, Ritzl, A, Varga, Z, Frecska, E, Berecz, R (2013). Automated Neuropsychological Test Battery in depression – preliminary data. Neuropsychopharmacologia Hungarica 15, 5–11.Google Scholar
Esel, E, Kose, K, Hacimusalar, Y, Ozsoy, S, Kula, M, Candan, Z, Turan, T (2008). The effects of electroconvulsive therapy on GABAergic function in major depressive patients. Journal of ECT 24, 224–228.Google Scholar
Falconer, DW, Cleland, J, Fielding, S, Reid, IC (2010). Using the Cambridge Neuropsychological Test Automated Battery (CANTAB) to assess the cognitive impact of electroconvulsive therapy on visual and visuospatial memory. Psychological Medicine 40, 1017–1025.Google Scholar
Fernie, G, Bennett, DM, Currie, J, Perrin, JS, Reid, IC (2014). Detecting objective and subjective cognitive effects of electroconvulsive therapy: intensity, duration and test utility in a large clinical sample. Psychological Medicine 44, 2985–2994.CrossRefGoogle Scholar
Gilbert, PE, Kesner, RP (2003). Localization of function within the dorsal hippocampus: the role of the CA3 subregion in paired-associate learning. Behavioral Neuroscience 117, 1385–1394.Google Scholar
Guy, W (1976). ECDEU Assessment Manual for Psycopharmacology. US Department of Health, Education, and Welfare Public Health Service Alcohol, Drug abuse, and Mental Health Administration: MD.Google Scholar
Hamilton, M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56–62.CrossRefGoogle ScholarPubMed
Jordanova, V, Maric, NP, Alikaj, V, Bajs, M, Cavic, T, Iosub, D, Mihai, A, Szalontay, A, Sartorius, N (2011). Prescribing practices in psychiatric hospitals in Eastern Europe. European Psychiatry 26, 414–418.CrossRefGoogle ScholarPubMed
Jovanovic, V, Gavrilov-Jerkovic, V, Zuljevic, D, Brdaric, D (2014). Psychometric evaluation of the Depression Anxiety Stress Scales – 21 (DASS-21) in a Serbian student sample. Psihologija 47, 93–112.Google Scholar
Kemps, E, Newson, R (2006). Comparison of adult age differences in verbal and visuo-spatial memory: the importance of ‘pure’, parallel and validated measures. Journal of Clinical and Experimental Neuropsychology 28, 341–356.Google Scholar
Langston, RF, Stevenson, CH, Wilson, CL, Saunders, I, Wood, ER (2010). The role of hippocampal subregions in memory for stimulus associations. Behavioural Brain Research 215, 275–291.Google Scholar
Leiknes, KA, Jarosh-von Schweder, L, Hoie, B (2012). Contemporary use and practice of electroconvulsive therapy worldwide. Brain and Behavior 2, 283–344.Google Scholar
Lovibond, SH, Lovibond, PF (1995). Manual for the Depression Anxiety Stress Scales. Psychology Foundation: Sydney.Google Scholar
Maric, NP, Stojiljkovic, DJ, Pavlovic, Z, Jasovic-Gasic, M (2012). Factors influencing the choice of antidepressants: a study of antidepressant prescribing practice at University Psychiatric Clinic in Belgrade. Vojnosanitetski Pregled 69, 308–301.CrossRefGoogle ScholarPubMed
McClintock, SM, Choi, J, Deng, ZD, Appelbaum, LG, Krystal, AD, Lisanby, SH (2014). Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. Journal of ECT 30, 165–176.Google Scholar
McCormick, LM, Brumm, MC, Benede, AK, Lewis, JL (2009). Relative ineffectiveness of ultrabrief right versus bilateral electroconvulsive therapy in depression. Journal of ECT 25, 238–242.Google Scholar
Pangman, VC, Sloan, J, Guse, L (2000). An examination of psychometric properties of the mini-mental state examination and the standardized mini-mental state examination: implications for clinical practice. Applied Nursing Research 13, 209–213.Google Scholar
Payne, NA, Prudic, J (2009). Electroconvulsive therapy: Part I. A perspective on the evolution and current practice of ECT. Journal of Psychiatric Practice 15, 346–368.CrossRefGoogle Scholar
Petrides, G, Fink, M (1996). The ‘half-age’ stimulation strategy for ECT dosing. Convulsive Therapy 12, 138–146.Google ScholarPubMed
Rabbitt, P, Lowe, C (2000). Patterns of cognitive ageing. Psychological Research 63, 308–316.Google Scholar
Rock, PL, Roiser, PJ, Riedel, WJ, Blackwell, AD (2013). Cognitive impairment in depression: a systematic review and meta-analysis. Psychological Medicine 44, 2029–2040.Google Scholar
Rotheneichner, P, Lange, S, O'Sullivan, A, Marschallinger, J, Zaunmair, P, Geretsegger, C, Aigner, L, Couillard-Despres, S (2014). Hippocampal neurogenesis and antidepressive therapy: shocking relations. Neural Plasticity 2014, 723915.Google Scholar
Sackeim, HA (2004). The convulsant and anticonvulsant properties of electroconvulsive therapy: towards a focal form of brain stimulation. Clinical Neuroscience Research 4, 39–57.CrossRefGoogle Scholar
Semkovska, M, McLoughlin, DM (2010). Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biological Psychiatry 68, 568–577.Google Scholar
Semkovska, M, McLoughlin, DM (2013). Measuring retrograde autobiographical amnesia following electroconvulsive therapy: historical perspective and current issues. Journal of ECT 29, 127–133.Google Scholar
Shapira, B, Tubi, N, Lerer, B (2000). Balancing speed of response to ECT in major depression and adverse cognitive effects: role of treatment schedule. Journal of ECT 16, 97–109.Google Scholar
Sheline, YI, Price, JL, Yan, Z, Mintun, MA (2010). Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proceedings of the National Academy of Sciences USA 107, 11020–11025.CrossRefGoogle ScholarPubMed
Sienaert, P, Vansteelandt, K, Demyttenaere, K, Peuskens, J (2010). Randomized comparison of ultra-briefbifrontal and unilateral electroconvulsive therapy for major depression: cognitive side-effects. Journal of Affective Disorders 122, 60–67.CrossRefGoogle ScholarPubMed
Soei, E, Daum, I (2008). Course of relational and non-relational recognition memory across the adult lifespan. Learning and Memory 15, 21–28.Google Scholar
Spiric, Z, Stojanovic, Z, Samardzic, R, Milovanovic, S, Gazdag, G, Maric, NP (2014). Electroconvulsive therapy practice in Serbia today. Psychiatria Danubina 26 66–69.Google ScholarPubMed
Tsaltas, E, Kalogerakou, S, Papakosta, VM, Kontis, D, Theochari, E, Koutroumpi, M, Anyfandi, E, Michopoulos, I, Poulopoulou, C, Papadimitriou, G, Oulis, P (2011). Contrasting patterns of deficits in visuospatial memory and executive function in patients with major depression with and without ECT referral. Psychological Medicine 41, 983–995.Google Scholar
UK ECT Review Group (2003). Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 361, 799–808.CrossRefGoogle Scholar
Wechsler, D (1981). Manual for the Wechsler Adult Intelligence Scale – Revised (WAIS-R). Psychological Corporation: San Antonio, TX.Google Scholar
Yoon, J, Seo, Y, Kim, J, Lee, I (2011). Hippocampus is required for paired associate memory with neither delay nor trial uniqueness. Learning and Memory 19, 1–8.Google Scholar