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Affective symptoms and intra-individual variability in the short-term course of cognitive functioning in bipolar disorder

Published online by Cambridge University Press:  09 December 2011

C. A. Depp ,
G. N. Savla ,
L. A. Vergel de Dios ,
B. T. Mausbach  and
B. W. Palmer
C. A. Depp*
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
G. N. Savla
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
L. A. Vergel de Dios
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
B. T. Mausbach
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
B. W. Palmer
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Veterans Medical Research Foundation, VA San Diego, La Jolla, CA, USA
*
*Address for correspondence: C. A. Depp, Ph.D., University of California, San Diego, Department of Psychiatry, 9500 Gilman Drive (0664), La Jolla, CA 92093-0664, USA. (Email: cdepp@ucsd.edu)
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Abstract

Background

Few studies have examined the short-term course of cognitive impairments in bipolar disorder (BD). Key questions are whether trajectories in symptoms covary with cognitive function and whether BD is associated with increased intra-individual variability in cognitive abilities.

Method

Forty-two out-patients with BD and 49 normal comparison (NC) subjects were administered a battery of neuropsychological tests at baseline, 6, 12 and 26 weeks, along with concurrent ratings of depressive and manic symptom severity. Mixed-effects regressions were used to model relationships between time, diagnosis and symptom severity on composite cognitive performance. Within-person variance in cognitive functioning across time was calculated for each subject.

Results

BD patients had significantly worse performance in cognitive ability across time points, but both groups showed significant improvement in cognitive performance over repeated assessments (consistent with expected practice effects). BD was associated with significantly greater intra-individual variability in cognitive ability than NCs; within-person variation was negatively related to baseline cognitive ability in BD but not NC subjects. Changes in affective symptoms over time did not predict changes in cognitive ability.

Conclusions

Moderate changes in affective symptoms did not covary with cognitive ability in BD. The finding of elevated intra-individual variability in BD may reduce capacity to estimate trajectories of cognitive ability in observational and treatment studies.

Keywords

Bipolar disordercognitive functioningdepressionintra-individual variabilitylongitudinal statistical analysisneuropsychology
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 7 , July 2012 , pp. 1409 - 1416
Copyright
Copyright © Cambridge University Press 2011

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Supplementary material: File

Depp Supplementary Figure

Fig. S1. Plots of individual trajectories in cognitive ability in (a) NC and (b) BD subjects.

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