Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T08:18:39.350Z Has data issue: false hasContentIssue false
  • English
  • Français

Alpha-2 adrenergic receptor function in post-stroke depression

Published online by Cambridge University Press:  09 July 2009

Siobhan Barry  and
Timothy G. Dinan
Siobhan Barry*
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland
Timothy G. Dinan
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland
*
1Address for correspondence: Dr Siobhan Barry, Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin 8, Ireland.
Get access Rights & Permissions [Opens in a new window]

Synopsis

The growth hormone (GH) response to desipramine was measured in ten patients meeting criteria for post-stroke depression (PSD), eight age-matched post-stroke (PS) nondepressed patients and eight healthy controls. Responses were significantly blunted in patients with PSD. These findings suggest diminished alpha-2 adrenoceptor function may be an important marker for PSD.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 2 , May 1990 , pp. 305 - 309
Copyright
Copyright © Cambridge University Press 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barry, S. & Dinan, T. G. (1990). Neuroendocrine challenge tests in depression: a study of growth hormone, TSH and cortisol release. Journal of Affective Disorders (In the press.)Google Scholar
Bobarth, K. & Bobarth, B. (1978). Short assessment and treatment planning for adult hemiplegia. In Adult hemiplegia: Evaluation and Treatment (ed. Bobarth, B.), pp. 28–57. Heinemann: London.Google Scholar
Charatan, F. B. & Fisk, A. (1978). The mental and emotional results of strokes. New York State Journal of Medicine 78, 1403–1405.Google ScholarPubMed
Charney, D. S., Heninger, G. R., Sternberg, D. E., Redmond, D. E., Leckman, J. F., Maas, J. W. & Roth, R. H. (1982). Adrenergic receptor sensitivity in depression. Effects of clonidine in depressed patients and healthy subjects. Archives of General Psychiatry 39, 290–294.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1985). Biological markers in depression. In Recent Advances in Clinical Psychiatry, Number 5 (ed. Granville-Grossman, K.), pp. 201–224. Churchill-Livingstone: Edinburgh.Google Scholar
Checkley, S. A., Slade, A. P. & Shur, E. (1981). Growth hormone and other responses to clonidine in patients with endogenous depression. British Journal of Psychiatry 138, 51–55.CrossRefGoogle ScholarPubMed
Checkley, S. A., Corn, T. H., Glass, I. B., Burton, S. W. & Burke, C. A. (1986). The responsiveness of central alpha-2 adrenoceptors in depression. In The Biology of Depression (ed. Deakin, J. F. W.), pp. 100–120. Gaskell: London.Google Scholar
Corn, T. H., Hale, A. S., Thompson, C., Bridges, P. K. & Checkley, S. A. (1984). A comparison of the GH responses to clonidine and apomorphine in the same depressed patients. British Journal of Psychiatry 144, 636–639.Google Scholar
Dinan, T. G. & Barry, S. (1990). Growth hormone responses to desipramine in endogenous and non-endogenous depression. British Journal of Psychiatry. (In the press.)Google Scholar
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975). A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189–198.Google Scholar
Folstein, M. F., Maiberger, R. & McHugh, P. (1977). Mood disorder as a specific complication of stroke. Journal of Neurology, Neurosurgery and Psychiatry 40, 1018–1020.Google Scholar
Glass, I. B., Checkley, S. A., Shur, E. & Dowling, S. (1982). The effect of desipramine upon central adrenergic function in depressed patients. British Journal of Psychiatry 141, 372–376.Google Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery & Psychiatry 23, 56–62.Google Scholar
Katona, C. L. E., Theodoru, A. E., Davies, S. L., Yamagushi, Y., Tunnicliffe, C. A., Hale, A. S., Horton, R. W., Kelly, J. S. & Paykel, E. S. (1986). Platelet binding and neuroendocrine responses in depression. In The Biology of Depression (ed. Deakin, J. F. W.), pp. 121–136. Gaskell: London.Google Scholar
Laakman, G. (1980). Effects of antidepressants on the secretion of pituitary hormones in healthy subjects, neurotic depressive patients and endogenous depressive patients. Nervenarzt 51, 725–732.Google Scholar
Laakman, G., Dieterle, D., Weiss, L. & Schmauss, M. (1981). Therapeutic and neuroendocrine studies using yohimbine and antidepressants in depressed patients and healthy subjects. In New Vistas in Depression (ed. Langer, S. Z., Takahastin, R., Segawa, T. and Briley, M.), pp. 295–301. Pergamon: New York.Google Scholar
Laakman, G., Zygan, K., Schoen, H. W., Weiss, A., Wittman, M., Meissner, R. & Blaschke, D. (1986). Effect of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desipramine-induced pituitary hormone stimulation in humans. 1. Growth hormone. Psychoneuroendocrinology 11, 447–461.CrossRefGoogle Scholar
Lipsey, J. K., Spencer, W. C., Rabins, P. V. & Robinson, R. G. (1986). Phenomenological comparison of poststroke depression and functional depression. American Journal of Psychiatry 143, 527–529.Google ScholarPubMed
Lishman, W. A. (1988). Organic Psychiatry (2nd edn.). Blackwell: London.Google Scholar
Lovinger, R., Holland, J., Kaplan, S., Grummach, M. M., Boryczka, A. T., Shackleford, R., Salmon, J., Reid, I. A. & Ganong, W. F. (1976). Pharmacological evidence for stimulation of growth hormone secretion by a central noradrenergic system in dogs. Neuroscience 1, 443–450.Google Scholar
Matussek, N., Ackenhail, M., Hippius, H., Muller, F., Schroder, H. Th., Schultes, H. & Wasilewski, B. (1980). Effect of clonidine on growth hormone release in psychiatric patients. Psychiatric Research 2, 25–36.Google Scholar
Meltzer, H. Y., Kolakowska, T., Fang, U. S., Fogg, L., Robertson, A. W., Lewine, R., Strahilevitz, M. & Busch, D. (1984). Growth hormone and prolactin response to apomorphine in schizophrenia and the major affective disorders. Archives of General Psychiatry 41, 512–519.CrossRefGoogle ScholarPubMed
Raite, S. (1983). The standards of growth hormone assays. In Evaluation of Growth Hormone Secretion (ed. Laron, Z. and Butenandt, O.), pp. 189–201. Karger: Basel.Google Scholar
Robinson, R. G. (1981). A model for the study of stroke using the rat. American Journal of Pathology 104, 103–105.Google Scholar
Robinson, R. G. & Coyle, J. T. (1980). The differential effect of right versus left hemispheric cerebral infarction on catecholamines and behaviour in the rat. Brain Research 213, 387–395.Google Scholar
Robinson, R. G. & Szetela, B. (1981). Mood changes following left hemisphere injury. Annals of Neurology 9, 447–453.Google Scholar
Robinson, R. G., Kubos, K. L., Starr, L. B., Rao, K. & Price, T. R. (1984). Mood changes in stroke patients: importance of location of lesion. Brain 107, 81–93.CrossRefGoogle ScholarPubMed
Ross, E. D., Gordon, W. A., Hibbard, M. & Egelko, S. (1986). The dexamethasone suppression test, poststroke depression and the validity of DSM-111 based diagnostic criteria. American Journal of Psychiatry 143, 1200–1201.CrossRefGoogle Scholar
Schildkraut, J. J. (1965). The catecholamine hypothesis of affective disorders: a review of supporting evidence. American Journal of Psychiatry 122, 509–522.Google Scholar
Shinar, D., Gross, C. R., Price, T. R., Bonko, M., Bolduc, P. L. & Robinson, R. G. (1986). Screening for depression in stroke patients: the reliability and validity of the Center for Epidemiologic Studies Depression Scale. Stroke 17, 241–245.CrossRefGoogle Scholar
Siever, L. J., Uhde, T. W., Silberman, E. K., Jimerson, D. C., Aloi, J. A., Post, R. M. & Murphy, D. L. (1982). Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatry Research 6, 171–183.CrossRefGoogle ScholarPubMed
Sinyor, D., Jacques, P., Kaloupek, D. G., Becker, R., Goldberg, M. & Coppersmith, H. (1986). Poststroke depression and lesion location: an attempted replication. Brain 109, 537–546.Google Scholar
Starkstein, S. E. & Robinson, R. G. (1989). Affective disorders and cerebral vascular diseases. British Journal of Psychiatry 154, 170–182.CrossRefGoogle Scholar
Terry, L. C. & Martin, J. B. (1981). Evidence for alpha-adrenergic regulation of episodic growth hormone and prolactin secretion in the undisturbed male rat. Endocrinology 108, 1869–1873.Google Scholar