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Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder

Published online by Cambridge University Press:  30 July 2018

Tingting Xu ,
Qing Zhao ,
Pei Wang ,
Qing Fan ,
Jue Chen ,
Haiyin Zhang ,
Zhi Yang ,
Dan J. Stein  and
Zhen Wang
Tingting Xu
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Qing Zhao
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Pei Wang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Qing Fan
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Jue Chen
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Haiyin Zhang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Zhi Yang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China
Dan J. Stein
Affiliation:
Department of Psychiatry and South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa
Zhen Wang*
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China Shanghai Key Laboratory of Psychotic Disorders, PR China
*
Author for correspondence: Zhen Wang, E-mail: wangzhen@smhc.org.cn, wangzhen@foxmail.com
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Abstract

Background

The role of the cerebellum in obsessive-compulsive disorder (OCD) has drawn increasing attention. However, the functional connectivity between the cerebellum and the cerebral cortex has not been investigated in OCD, nor has the relationship between such functional connectivity and clinical symptoms.

Methods

A total of 27 patients with OCD and 21 healthy controls (HCs) matched on age, sex and education underwent magnetic resonance imaging (MRI). Seed-based connectivity analyses were performed to examine differences in cerebellar-cerebral connectivity in patients with OCD compared with HCs. Associations between functional connectivity and clinical features in OCD were analyzed.

Results

Compared with HCs, OCD patients showed significantly decreased cerebellar-cerebral functional connectivity in executive control and emotion processing networks. Within the OCD group, decreased functional connectivity in an executive network spanning the right cerebellar Crus I and the inferior parietal lobule was positively correlated with symptom severity, and decreased connectivity in an emotion processing network spanning the left cerebellar lobule VI and the lingual gyrus was negatively correlated with illness duration.

Conclusions

Altered functional connectivity between the cerebellum and cerebral networks involved in cognitive-affective processing in patients with OCD provides further evidence for the involvement of the cerebellum in the pathophysiology of OCD, and is consistent with impairment in executive control and emotion regulation in this condition.

Keywords

Cerebellar circuitsexecutive control networkfunctional connectivityobsessive-compulsive disorder
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 7 , May 2019 , pp. 1156 - 1165
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

These authors contributed equally to this work and should be considered co-first authors

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