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Association between major depressive disorder and physical illness

Published online by Cambridge University Press:  09 July 2009

S. O. Moldin ,
W. A. Scheftner ,
J. P. Rice ,
E. Nelson ,
M. A. Knesevich  and
H. Akiskal
S. O. Moldin*
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
W. A. Scheftner
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
J. P. Rice
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
E. Nelson
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
M. A. Knesevich
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
H. Akiskal
Affiliation:
Department of Psychiatry, and the Division of Biostatistics, Washington University School of Medicine; Department of Psychology, Malcolm Bliss Mental Health Center, St Louis, MO; Department of Psychiatry, Rush College of Medicine and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL; Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, TX; and the Office of the Director, NIMH, Rockville, MD, USA
*
1Address for correspondence: Dr Steven O.Moldin, Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St Louis, MO 63110, USA.
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Synopsis

The association between major depressive disorder (MDD) and self-reported histories of specific physical illnesses was investigated in 320 controls and 1968 first-degree relatives and 254 spouses of probands in the NIMH Collaborative Depression study. The Schedule for Affective Disorders and Schizophrenia-Lifetime Version was used to assign Research Diagnostic Criteria (RDC) diagnoses and a structured self-report instrument was used to assess lifetime medical history. Lifetime MDD was diagnosed in 914 subjects, 402 of whom had been hospitalized or received somatic treatment (‘treated’ MDD). Strong associations were observed between MDD (either treated or untreated) and both frequent/severe headaches and migraine headaches. There was a marked gender effect such that the relative odds for a woman with treated MDD to report migraine were over 5:1. Other associations were found between MDD and skin infections, respiratory illness, ulcer, hypotension, and diabetes. This is the largest non-patient sample using standardized assessment of mental disorders by direct interview in which associations between specific physical illnesses and MDD have been demonstrated. Implications for clinical practice and neurobiological research in depression are discussed.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 3 , August 1993 , pp. 755 - 761
Copyright
Copyright © Cambridge University Press 1993

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References

Andreasen, N. C., Rice, J., Endicott, J., Coryell, W., Grove, W. M. & Reich, T. (1987). Familial rates of affective disorder. Archives of General Psychiatry 44, 461–469.CrossRefGoogle ScholarPubMed
Breslau, N., Davis, G. C. & Andreski, P. (1991). Migraine, psychiatric disorders, and suicide attempts. Psychiatry Research 37, 11–23.CrossRefGoogle ScholarPubMed
Broadhead, W. E., Clapp-Channing, N. E., Finch, J. N. & Copeland, J. A. (1989). Effects of medical illness and somatic symptoms on treatment of depression in a family medicine residency practice. General Hospital Psychiatry 11, 194–200.CrossRefGoogle Scholar
Jarman, J., Fernandez, M., Davies, P. T. G., Glover, V., Steiner, T. J., Thompson, C., Rose, F. C. & Sandler, M. (1990). High incidence of endogenous depression in migraine: confirmation by tyramine test. Journal of Neurology, Neurosurgery and Psychiatry 53, 573–575.CrossRefGoogle ScholarPubMed
Katz, M. M. & Klerman, G. L. (1979). Overview of the clinical studies program. American Journal of Psychiatry 136, 49–51.Google ScholarPubMed
Keitner, G. I., Ryan, C. E., Miller, I. W., Kohn, R. & Epstein, N. B. (1991). 12-Month outcome of patients with major depression and comorbid psychiatric or medical illness. American Journal of Psychiatry 148, 345–350.Google ScholarPubMed
Keitner, G. I., Ryan, C. E., Miller, I. W. & Norman, W. H. (1992). Recovery and major depression. American Journal of Psychiatry 149, 93–99.Google ScholarPubMed
Levenson, J. L., Hamer, R., Silverman, J. J. & Rossiter, L. F. (1987). Psychopathology in medical inpatients and its relationship to length of hospital stay. International Journal of Psychiatry in Medicine 16, 231–237.CrossRefGoogle Scholar
Lustman, P. J., Clouse, R. E., Carney, R. M. & Griffith, L. S. (1987). Characteristics of depression in adults with diabetes.Proceedings of NIMH Conference on Mental Disorders in General Health Care Settings,Seattle, WA. The Foundation for Group Health Cooperative of Puget Sound 1, 127–129.Google Scholar
Lustman, P. J., Gavard, J. A. & Clouse, R. E. (1992). Depression in adults with diabetes. Diabetes Care 15, 1631–1639.CrossRefGoogle ScholarPubMed
Marchesi, C., DeFerri, A., Petrolini, N., Govi, A., Manzoni, G. C., Coiro, V. & De Risio, C. (1989). Prevalence of migraine and muscle tension headache in depressive disorders. Journal of Affective Disorders 16, 33–36.CrossRefGoogle ScholarPubMed
Merikangas, K. R., Risch, N. J., Merikangas, J. R., Weissman, M. M. & Kidd, K. K. (1988). Migraine and depression: association and familial transmission. Journal of Psychiatry Research 22, 119–129.CrossRefGoogle ScholarPubMed
Merikangas, K. R., Angst, J. & Hansruedi, I. (1990). Migraine and psychopathology. Archies of General Psychiatry 47, 849–853.CrossRefGoogle ScholarPubMed
Moldin, S. O., Reich, T. & Rice, J. P. (1991). Current perspectives on the genetics of unipolar depression. Behavioral Genetics 21, 211–241.CrossRefGoogle ScholarPubMed
Murrell, S. A., Himmelfarb, S. & Wright, K. (1983). Prevalence of depression and its correlates in older adults. American Journal of Epidemiology 117, 173–185.CrossRefGoogle ScholarPubMed
Persky, V. W., Kempthorn-Rawson, J. & Shekelle, R. B. (1987). Personality and risk of cancer: 20-year follow-up of the Western Electric Study. Psychosomatic Medicine 49, 435–449.CrossRefGoogle ScholarPubMed
Rasmussen, B. K., Jensen, R., Schroll, M. & Olesen, J. (1991). Epidemiology of headache in a general population – a prevalence study. Journal of Clinical Epidemiology 44, 1147–1157.CrossRefGoogle Scholar
Rice, J. P., Endicott, J., Knesevich, M. A. & Rochberg, N. (1987). The estimation of diagnostic sensitivity using stability data. Journal of Psychiatry Research 21, 337–345.CrossRefGoogle ScholarPubMed
Rice, J. P., Rochberg, N., Endicott, J., Lavori, P. W. & Miller, C. (1992). Stability of psychiatric diagnoses. Archives of General Psychiatry 49, 824–830.CrossRefGoogle ScholarPubMed
SAS Institute Inc. (1986). SUGI Supplemental Library User's Guide. Version 5. SAS Institute, Cary, NC.Google Scholar
Spierings, E. L. H. (1987). The physiology and biochemistry of stress in relation to headache. In Psychiatric Aspects of Headache (ed. Adler, C. S., Adler, S. M. and Packard, R. C.), pp. 237–253. Williams & Wilkins: Baltimore, Maryland.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1975). Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 2nd edn.New York State Psychiatric Institute, Biometrics Research Unit: New York.Google Scholar
Spitzer, R. L. & Endicott, J. (1977). Schedule for Affective Disorders and Schizophrenia Lifetime Version (SADS-L), 3rd edn.New York State Psychiatric Institute, Biometrics Research Unit: New York.Google Scholar
Stern, R. A. & Bachman, D. L. (1991). Depressive symptoms following stroke. American Journal of Psychiatry 148, 351–356.Google ScholarPubMed
Stewart, W. F., Lipton, R. B., Celentano, D. D. & Reed, M. L. (1992). Prevalence of migraine headaches in the United States. Journal of the American Medical Association 267, 64–69.CrossRefGoogle ScholarPubMed
Warshaw, M. G., Lavori, P. W. & Klerman, G. L. (1991). Are secular trends in major depression an artifact of recall? Journal of Psychiatric Research 25, 141–151.CrossRefGoogle ScholarPubMed
Wells, K. B., Golding, J. M. & Burnam, M. A. (1989). Affective, substance use, and anxiety disorders in persons with arthritis, diabetes, heart disease, high blood pressure, or chronic lung conditions. General Hospital Psychiatry 11, 320–327.CrossRefGoogle ScholarPubMed
Wells, K. B., Rogers, W., Burnam, A., Greenfield, S. & Ware, J. E. (1991). How the medical comorbidity of depressed patients differs across health care settings. American Journal of Psychiatry 148, 1688–1696.Google ScholarPubMed
Ziegler, D. K., Hurwitz, A., Hassanein, R. S., Kodanaz, H., Preskorn, S. H. et al. (1987). Migraine prophylaxis. Archives of Neurology 44, 486–489.CrossRefGoogle ScholarPubMed
Zonderman, A. B., Costa, P. T. & McCrae, R. R. (1989). Depression as a risk for cancer morbidity and mortality in a nationally representative sample. Journal of the American Medical Association 262, 1191–1195.CrossRefGoogle Scholar