Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-10T15:46:43.708Z Has data issue: false hasContentIssue false

Attention bias modification augments cognitive–behavioral group therapy for social anxiety disorder: a randomized controlled trial

Published online by Cambridge University Press:  20 December 2017

Amit Lazarov*
Affiliation:
Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
Sofi Marom
Affiliation:
Anxiety Disorders and Behavior Therapy Unit, Outpatient Department, Geha Mental Health Center, Tel-Aviv University, Tel-Aviv, Israel
Naomi Yahalom
Affiliation:
Anxiety Disorders and Behavior Therapy Unit, Outpatient Department, Geha Mental Health Center, Tel-Aviv University, Tel-Aviv, Israel
Daniel S. Pine
Affiliation:
Section on Developmental Affective Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
Haggai Hermesh
Affiliation:
Anxiety Disorders and Behavior Therapy Unit, Outpatient Department, Geha Mental Health Center and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Yair Bar-Haim
Affiliation:
School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel
*
Author for correspondence: Amit Lazarov, E-mail: amitlaza@post.tau.ac.il

Abstract

Background

Cognitive–behavioral group therapy (CBGT) is a first-line treatment for social anxiety disorder (SAD). However, since many patients remain symptomatic post-treatment, there is a need for augmenting procedures. This randomized controlled trial (RCT) examined the potential augmentation effect of attention bias modification (ABM) for CBGT.

Methods

Fifty patients with SAD from three therapy groups were randomized to receive an 18-week standard CBGT with either ABM designed to shift attention away from threat (CBGT + ABM), or a placebo protocol not designed to modify threat-related attention (CBGT + placebo). Therapy groups took place in a large mental health center. Clinician and self-report measures of social anxiety and depression were acquired pre-treatment, post-treatment, and at 3-month follow-up. Attention bias was assessed at pre- and post-treatment.

Results

Patients randomized to the CBGT + ABM group, relative to those randomized to the CBGT + placebo group, showed greater reductions in clinician-rated SAD symptoms post-treatment, with effects maintained at 3-month follow-up. Group differences were not evident for self-report or attention-bias measures, with similar reductions in both groups. Finally, reduction in attention bias did not mediate the association between group and reduction in Liebowitz Social Anxiety Scale Structured Interview (LSAS) scores.

Conclusions

This is the first RCT to examine the possible augmenting effect of ABM added to group-based cognitive–behavioral therapy for adult SAD. Training patients’ attention away from threat might augment the treatment response to standard CBGT in SAD, a possibility that could be further evaluated in large-scale RCTs.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

This work reflects equal contribution of these authors.

References

Abend, R, Karni, A, Sadeh, A, Fox, NA, Pine, DS and Bar-Haim, Y (2013) Learning to attend to threat accelerates and enhances memory consolidation. PLoS ONE 8, e62501.Google Scholar
Amir, N, Beard, C, Taylor, CT, Klumpp, H, Elias, J, Bums, M et al. (2009) Attention training in individuals with generalized social phobia: a randomized controlled trial. Journal of Consulting and Clinical Psychology 77, 961973.Google Scholar
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (4th ed. text revised). American Psychiatric Publishing: Washington, DC.Google Scholar
Amir, N, Taylor, CT and Donohue, MC (2011) Predictors of response to an attention modification program in generalized social phobia. Journal of Consulting and Clinical Psychology 79, 533541.Google Scholar
Baker, SL, Heinrichs, N, Kim, HJ and Hofmann, SG (2002) The Liebowitz social anxiety scale as a self-report instrument: a preliminary psychometric analysis. Behaviour Research and Therapy 40, 701715.Google Scholar
Bandelow, B, Baldwin, DS, Dolberg, OT, Andersen, HF and Stein, DJ (2006) What is the threshold for symptomatic response and remission for major depressive disorder, panic disorder, social anxiety disorder, and generalized anxiety disorder? Journal of Clinical Psychiatry 67, 14281434.Google Scholar
Bar-Haim, Y (2010) Research review: attention bias modification (ABM): a novel treatment for anxiety disorders. Journal of Child Psychology and Psychiatry 51, 859870.Google Scholar
Barry, TJ, Vervliet, B and Hermans, D (2015) An integrative review of attention biases and their contribution to treatment for anxiety disorders. Frontiers in Psychology 6, Article 968.Google Scholar
Basanovic, J, Notebaert, L, Grafton, B, Hirsch, CR and Clarke, PJF (2017) Attentional control predicts change in bias in response to attentional bias modification. Behaviour Research and Therapy 99, 4756.Google Scholar
Beard, C (2011) Cognitive bias modification for anxiety: current evidence and future directions. Expert Review of Neurotherapeutics 11, 299311.Google Scholar
Beard, C, Sawyer, AT and Hofmann, SG (2012) Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review. Behavior Therapy 43, 724740.Google Scholar
Beck, AT, Steer, RA and Brown, GK (1996) BDI-II Manual, 2nd edn. San Antonio: Harcourt Brace & Company.Google Scholar
Bogels, SM and Mansell, W (2004) Attention processes in the maintenance and treatment of social phobia: hypervigilance, avoidance and self-focused attention. Clinical Psychology Review 24, 827856.Google Scholar
Browning, M, Holmes, EA and Harmer, CJ (2010) The modification of attentional bias to emotional information: a review of the techniques, mechanisms, and relevance to emotional disorders. Cognitive Affective & Behavioral Neuroscience 10, 820.Google Scholar
Carlbring, P, Apelstrand, M, Sehlin, H, Amir, N, Rousseau, A, Hofmann, SG et al. (2012) Internet-delivered attention bias modification training in individuals with social anxiety disorder – a double blind randomized controlled trial. BMC Psychiatry 12, 66.Google Scholar
Chartier, MJ, Walker, JR and Stein, MB (2003) Considering comorbidity in social phobia. Social Psychiatry and Psychiatric Epidemiology 38, 728734.Google Scholar
Clark, DM and Wells, A (1995) A cognitive model of social phobia. In Heimberg, RG, Liebowitz, MR, Hope, DA, Schnier, FR (eds). Social Phobia: Diagnosis, Assessment and Treatment. New York: Guildford Press, pp. 6993.Google Scholar
Connor, KM, Davidson, JRT, Churchill, LE, Sherwood, A, Foa, E and Weisler, RH (2000) Psychometric properties of the social phobia inventory (SPIN) – new self-rating scale. British Journal of Psychiatry 176, 379386.Google Scholar
DeWit, DJ, Ogborne, A, Offord, DR and MacDonald, K (1999) Antecedents of the risk of recovery from DSM-III-R social phobia. Psychological Medicine 29, 569582.Google Scholar
Fitzgerald, A, Rawdon, C and Dooley, B (2016) A randomized controlled trial of attention bias modification training for socially anxious adolescents. Behaviour Research and Therapy 84, 18.Google Scholar
Fresco, DM, Coles, ME, Heimberg, RG, Liebowitz, MR, Hami, S, Stein, MB et al. (2001) The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats. Psychological Medicine 31, 10251035.Google Scholar
Furmark, T (2002) Social phobia: overview of community surveys. Acta Psychiatrica Scandinavica 105, 8493.Google Scholar
Hallion, LS and Ruscio, AM (2011) A meta-analysis of the effect of cognitive bias modification on anxiety and depression. Psychological Bulletin 137, 940958.Google Scholar
Hayes, AF (2013) Introduction to Meditation, Moderation, and Conditional Process Analysis: A Regression-based Approach. New York: Guilford Press.Google Scholar
Hayes, AF and Preacher, KJ (2014) Statistical mediation analysis with a multicategorical independent variable. British Journal of Mathematical & Statistical Psychology 67, 451470.Google Scholar
Heeren, A, Lievens, L and Philippot, P (2011) How does attention training work in social phobia: disengagement from threat or re-engagement to non-threat? Journal of Anxiety Disorders 25, 11081115.Google Scholar
Heeren, A, Mogoase, C, Philippot, P and McNally, RJ (2015) Attention bias modification for social anxiety: a systematic review and meta-analysis. Clinical Psychology Review 40, 7690.Google Scholar
Heeren, A, Reese, HE, McNally, RJ and Philippot, P (2012) Attention training toward and away from threat in social phobia: effects on subjective, behavioral, and physiological measures of anxiety. Behaviour Research and Therapy 50, 3039.Google Scholar
Heimberg, RG (2002) Cognitive-behavioral therapy for social anxiety disorder: current status and future directions. Biological Psychiatry 51, 101108.Google Scholar
Heimberg, RG and Becker, RE (2002) Cognitive-behavioral Group Therapy for Social Phobia: Basic Mechanisms and Clinical Strategies. New York: Guilford Press.Google Scholar
Heimberg, RG, Horner, KJ, Juster, HR, Safren, SA, Brown, EJ, Schneier, FR et al. (1999) Psychometric properties of the Liebowitz Social Anxiety Scale. Psychological Medicine 29, 199212.Google Scholar
Heimberg, RG, Juster, HR, Hope, DA and Mattia, JI (1995) Chapter: cognitive-behavioral group treatment: description, case presentation, and empirical support. In Stein, MB (ed.). Social Phobia: Clinical and Research Perspectives. Arlington, VA, USA: American Psychiatric Association, pp. 293321.Google Scholar
Hofmann, SG and Bogels, SM (2006) Recent advances in the treatment of social phobia: introduction to the special issue. Journal of Cognitive Psychotherapy 20, 35.Google Scholar
Jacobson, NS and Truax, P (1991) Clinical-significance – a statistical approach to defining meaningful change in psychotherapy-research. Journal of Consulting and Clinical Psychology 59, 1219.Google Scholar
Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR and Walters, EE (2005 a) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry 62, 593602.Google Scholar
Kessler, RC, Chiu, WT, Demler, O and Walters, EE (2005 b) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry 62, 617627.Google Scholar
Kushnir, J, Marom, S, Mazar, M, Sadeh, A and Hermesh, H (2014) The link between social anxiety disorder, treatment outcome, and sleep difficulties among patients receiving cognitive behavioral group therapy. Sleep Medicine 15, 515521.Google Scholar
Lazarov, A, Abend, R, Seidner, S, Pine, DS and Bar-Haim, Y (2017) The effects of training contingency awareness during attention bias modification on learning and stress reactivity. Behavior Therapy 48, 638650.Google Scholar
Leichsenring, F, Salzer, S, Beutel, ME, Herpertz, S, Hiller, W, Hoyer, J et al. (2013) Psychodynamic therapy and cognitive-behavioral therapy in social anxiety disorder: a multicenter randomized controlled trial. American Journal of Psychiatry 170, 759767.Google Scholar
Levin, JB, Maron, S, Gur, S, Wechter, D and Hermesh, H (2002) Psychometric properties and three proposed subscales of a self-report version of the Liebowitz Social Anxiety Scale translated into Hebrew. Depression and Anxiety 16, 143151.Google Scholar
Liebowitz, MR (1987) Social phobia. Modern Problems of Pharmacopsychiatry 22, 141173.Google Scholar
Linetzky, M, Pergamin-Hight, L, Pine, DS and Bar-Haim, Y (2015) Quantitative evaluation of the clinical efficacy of attention bias modification treatment for anxiety disorders. Depression and Anxiety 32, 383391.Google Scholar
Lundh, LG and Öst, LG (2001) Attentional bias, self-consciousness and perfectionism in social phobia before and after cognitive-behaviour therapy. Scandinavian Journal of Behaviour Therapy 30, 416.Google Scholar
MacLeod, C and Clarke, PJF (2015) The attentional bias modification approach to anxiety intervention. Clinical Psychological Science 3, 5878.Google Scholar
MacLeod, C, Mathews, A and Tata, P (1986) Attentional bias in emotional disorders. Journal of Abnormal Psychology 95, 1520.Google Scholar
Marom, S, Gilboa-Schechtman, E, Aderka, IM, Weizman, A and Hermesh, H (2009) Impact of depression on treatment effectiveness and gains maintenance in social phobia: a naturalistic study of cognitive behavior group therapy. Depression and Anxiety 26, 289300.Google Scholar
Mattia, JI, Heimberg, RG and Hope, DA (1993) The revised stroop color-naming task in social phobics. Behaviour Research and Therapy 31, 305313.Google Scholar
McEvoy, PM (2007) Effectiveness of cognitive behavioural group therapy for social phobia in a community clinic: a benchmarking study. Behaviour Research and Therapy 45, 30303040.Google Scholar
McEvoy, PM, Nathan, P, Rapee, RM and Campbell, BNC (2012) Cognitive behavioural group therapy for social phobia: evidence of transportability to community clinics. Behaviour Research and Therapy 50, 258265.Google Scholar
McEvoy, PM and Perini, SJ (2009) Cognitive behavioral group therapy for social phobia with or without attention training: a controlled trial. Journal of Anxiety Disorders 23, 519528.Google Scholar
Mennin, DS, Fresco, DM, Heimberg, RG, Schneier, FR, Davies, SO and Liebowitz, MR (2002) Screening for social anxiety disorder in the clinical setting: using the Liebowitz Social Anxiety Scale. Journal of Anxiety Disorders 16, 661673.Google Scholar
Price, RB, Kuckertz, JM, Amir, N, Bar-Haim, Y, Carlbring, P and Wallace, ML (2017) Less is more: patient-level meta-analysis reveals paradoxical dose-response effects of a computer-based social anxiety intervention targeting attentional bias. Depression and Anxiety 34, 11061115.Google Scholar
Rapee, RM and Lim, L (1992) Discrepancy between self and observer ratings of performance in social phobics. Journal of Abnormal Psychology 101, 728731.Google Scholar
Rapee, RM, MacLeod, C, Carpenter, L, Gaston, JE, Frei, J, Peters, L et al. (2013) Integrating cognitive bias modification into a standard cognitive behavioural treatment package for social phobia: a randomized controlled trial. Behaviour Research and Therapy 51, 207215.Google Scholar
Reinecke, A, Waldenmaier, L, Cooper, MJ and Harmer, CJ (2013) Changes in automatic threat processing precede and predict clinical changes with exposure-based cognitive-behavior therapy for panic disorder. Biological Psychiatry 73, 10641070.Google Scholar
Riemann, BC, Kuckertz, JM, Rozenman, M, Weersing, VR and Amir, N (2013) Augmentation of youth cognitive behavioral and pharmacological interventions with attention modification: a preliminary investigation. Depression and Anxiety 30, 822828.Google Scholar
Safren, SA, Heimberg, RG, Horner, KJ, Juster, HR, Schneier, FR and Liebowitz, MR (1999) Factor structure of social fears: the Liebowitz Social Anxiety Scale. Journal of Anxiety Disorders 13, 253270.Google Scholar
Schmidt, LJ, Belopolsky, AV and Theeuwes, J (2015) Attentional capture by signals of threat. Cognition and Emotion 29, 687694.Google Scholar
Schmidt, NB, Richey, JA, Buckner, JD and Timpano, KR (2009) Attention training for generalized social anxiety disorder. Journal of Abnormal Psychology 118, 514.Google Scholar
Schneier, FR, Johnson, J, Hornig, CD, Liebowitz, MR and Weissman, MM (1992) Social phobia – comorbidity and morbidity in an epidemiologic sample. Archives of General Psychiatry 49, 282288.Google Scholar
Shechner, T, Rimon-Chakir, A, Britton, JC, Lotan, D, Apter, A, Bliese, PD et al. (2014) Attention bias modification treatment augmenting effects on cognitive behavioral therapy in children with anxiety: randomized controlled trial. Journal of the American Acadamy of Child and Adolescent Psychiatry 53, 6171.Google Scholar
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E et al. (1998) The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59, 2233.Google Scholar
Stein, MB and Kean, YM (2000) Disability and quality of life in social phobia: epidemiologic findings. American Journal of Psychiatry 157, 16061613.Google Scholar
Taylor, CT, Bomyea, J and Amir, N (2010) Attentional bias away from positive social information mediates the link between social anxiety and anxiety vulnerability to a social stressor. Journal of Anxiety Disorders 24, 403408.Google Scholar
Tobon, JI, Ouimet, AJ and Dozois, DJA (2011) Attentional bias in anxiety disorders following cognitive behavioral treatment. Journal of Cognitive Psychotherapy 25, 114129.Google Scholar
Tottenham, N, Tanaka, J, Leon, A, McCarry, T, Nurse, M, Hare, T et al. (2009) The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Research 168, 242249.Google Scholar
Turk, CL, Heimberg, RG and Hope, DA (2001) Chapter: social anxiety disorder. In Barlow, DH (ed.). Clinical Handbook of Psychological Disorders: A Step-by-step Treatment Manual, 3rd edn. New York, NY; USA: Guilford Press, pp. 114153.Google Scholar
Vens, M, Ziegler, A (2012) Generalized estimating equations and regression diagnostics for longitudinal controlled clinical trials: A case study. Computational Statistics & Data Analysis 56, 12321242.Google Scholar
White, LK, Sequeira, S, Britton, JC, Brotman, MA, Gold, AL, Berman, E et al. (2017) Complementary features of attention bias modification therapy and cognitive-behavioral therapy in pediatric anxiety disorders. American Journal of Psychiatry 174, 775784.Google Scholar
Zeger, SL, Liang, KY (1986) Longitudinal Data-Analysis for Discrete and Continuous Outcomes. Biometrics 42, 121130.Google Scholar
Zeger, SL, Liang, KY, Albert, PS (1988) Models for Longitudinal Data - a Generalized Estimating Equation Approach. Biometrics 44, 10491060.Google Scholar
Supplementary material: File

Lazarov et al supplementary material

Lazarov et al supplementary material 1

Download Lazarov et al supplementary material(File)
File 21.5 KB