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Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

Published online by Cambridge University Press:  09 July 2009

G. W. Ashcroft ,
Ivy M. Blackburn ,
D. Eccleston ,
A. I. M. Glen ,
W. Hartley ,
Nancy E. Kinloch ,
Mary Lonergan ,
L. G. Murray  and
I. A. Pullar
G. W. Ashcroft
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
Ivy M. Blackburn
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
D. Eccleston
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
A. I. M. Glen
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
W. Hartley
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
Nancy E. Kinloch
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
Mary Lonergan
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
L. G. Murray
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
I. A. Pullar
Affiliation:
From the Medical Research Council Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
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Synopsis

The concentration of the acid metabolites of dopamine, and 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA) respectively, were estimated in the cerebrospinal fluid of patients suffering from either unipolar or bipolar affective illness, both before and after recovery. Significantly low concentrations of HVA and 5-HIAA (P<0·01 and 0·05 respectively) were found in the unipolar depressed group and these did not return to normal on recovery. Depressed bipolar patients had levels within normal limits. In bipolar manic patients the HVA concentration fell on recovery to a level significantly lower (P<0·05) than controls. There was no difference in the levels of tryptophan in the CSF of any of the groups of patients nor was there any alteration on recovery. There was a high correlation between 5-HIAA and HVA in the same CSF. These findings are against the amine hypothesis which postulated in depression a lowered concentration of transmitter amine at synaptic junction.

Type
Research Article
Information
Psychological Medicine , Volume 3 , Issue 3 , August 1973 , pp. 319 - 325
Copyright
Copyright © Cambridge University Press 1973

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References

REFERENCES

Ashcroft, G. W., and Sharman, D. F. (1960). 5-Hydroxyindoles in human cerebrospinal fluids. Nature, 186, 1050–1051.Google Scholar
Ashcroft, G. W., Crawford, T. B. B., Eccleston, D., Sharman, D. F., MacDougall, E. J., Stanton, J. B., and Binns, J. K. (1966). 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet, 2, 1049–1052.CrossRefGoogle ScholarPubMed
Blackburn, I. M. (1972). A Psychometric Study of Unipolor and Bipolar Affective Disorder. Ph.D. Thesis.Google Scholar
Bulat, M., and Zivković, B. (1971). Origin of 5-hydroxyindole acetic acid in the spinal fluid. Science, 173, 738–740.CrossRefGoogle Scholar
Carlsson, A., Fuxe, K., and Ungerstedt, U. (1968). The effect of imipramine on central 5-hydroxytryptamine neurones. Journal of Pharmacy and Pharmacology, 20, 150–151.Google Scholar
Carlsson, A., and Lindqvist, M. (1963). Effect of chlorpromazinc or halopcridol on formatimi of 3-mellioxytyraminc and normetanephrine in mouse brain. Acta Pharmacologia, 20, 140 144.CrossRefGoogle ScholarPubMed
Coppen, A., Brooksbank, B. W. L., and Peet, M. (1972). Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet, 1, 1393.Google Scholar
Dencker, S. J., Malm, U., Roos, B.-E., and Werdinius, B. (1966). Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. Journal of Neurochemistry, 13, 1545–1548.Google Scholar
Eccleston, D., Ashcroft, G. W., Crawford, T. B. B., Stanton, J. B., Wood, D., and McTurk, P. H. (1970). Effect of tryptophan administration on 5H1AA in cerebrospinal fluid in man. Journal of Neurology, Neurosurgery and Psychiatry, 33, 269–272.Google Scholar
Eccleston, D., Ashcroft, G. W., Moir, A. T. B., Parker-Rhodes, A., Lutz, W., and O'Mahoney, D. P. (1968). A comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid. Journal of Neurochemistry, 15, 947–957.Google Scholar
Fuxe, K., and Ungerstedt, U. (1968). Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine. European Journal of Pharmacology, 4, 135–144.Google Scholar
Gottfries, C. G., Gottfries, I., Johansson, B., Olsson, R., Persson, T., Roos, B.-E., and Sjöstr¨m, R. (1971). Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex. Neuropharmacology, 10, 665–672.CrossRefGoogle ScholarPubMed
Guldberg, H. C., Ashcroft, G. W., and Crawford, T. B. B. (1966). Concentrations of 5-hydroxyindolylacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid. Life Sciences, 5, 1571–1575.Google Scholar
Guldberg, H. C., and Yates, C. M. (1968). Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the technique of serial sampling of the cerebrospinal fluid. British Journal of Pharmacology and Chemotherapy, 33, 457–471.Google Scholar
Guroff, G., and Udenfriend, S. (1962). Studies on aromatic amino acid uptake by rat brain in vivo. Journal of Biological Chemistry, 237, 803–806.CrossRefGoogle ScholarPubMed
Hargreaves, W. A. (1968). Systematic nursing observations of psychopathology. Archives of General Psychiatry, 18, 518 531.Google Scholar
Hess, S. M., and Udenfriend, S. (1959). A fluorometric procedure for the measurement of tryptamine in tissues. Journal of Pharmacology and Experimental Therapeutics, 127, 175–177.Google Scholar
Iversen, L. L. (1967). The Uptake and Storage of Noradrenaline in Sympathetic Nerves. Cambridge University Press: London.Google Scholar
Jéquier, E., Lovenberg, W., and Sjoerdsma, A. (1967). Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Molecular Pharmacology 3, 274–278.Google Scholar
Knott, P. J., and Curzon, G. (1972). Free tryptophan in plasma and brain tryptophan metabolism. Nature, 239, 452–453.CrossRefGoogle ScholarPubMed
McMenamy, R. H., Lund, C. C., and Oncley, J. L. (1957). Unbound amino acid concentrations in human blood plasmas. Journal of Clinical Investigation, 36, 1672–1679.CrossRefGoogle ScholarPubMed
M.R.C. Brain Metabolism Unit. (1972). Modified amine hypothesis for the aetiology of affective illness. Lancet, 2, 573–577.Google Scholar
Papeschi, R., and McClure, D. J. (1971). Homovanillic and 5-hydroxyindoleacetic acid in cerebrospial fluid of depressed patients. Archives of General Psychiatry, 25, 354–358.CrossRefGoogle Scholar
Perris, C. (ed.) (1966). A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavia, 42, suppl. 194.Google Scholar
Praag, H. M. van, Korf, J., and Puite, J. (1970). 5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. Nature, 225, 1259–1260.Google Scholar
Roos, B.-E., and Sjzöström, R. (1969). 5-Hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patients with manicdepressive psychosis. Pharmacological Clinics, 1, 153–155.Google Scholar
Ungerstedt, U. (1971). Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiologica Scandinavica, Suppl. 367, 69–93.Google Scholar
Wing, J. K. (1970). A standard form of psychiatric present state examination: a method for standardizing the classification of symptoms, in Psychiatric Epidemiology, pp. 93–108. Edited by Hare, E. H. and Wing, J. K.. Oxford University Press: London.Google Scholar