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Clinical and experimental aspects of interactions between amine oxidase inhibitors and amine re-uptake inhibitors

Published online by Cambridge University Press:  09 July 2009

E. Marley  and
Krystyna M. Wozniak
E. Marley*
Affiliation:
Department of Pharmacology, Institute of Psychiatry, London
Krystyna M. Wozniak
Affiliation:
Department of Pharmacology, Institute of Psychiatry, London
*
1 Address for correspondence: Professor E. Marley, Department of Pharmacology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

Dangerous and even fatal interactions can occur in man following combinations of antidepressants which include non-selective MAO inhibitors. To ascertain the causation, interactions reproducing the clinical phenomena have been elicited in animals with these combinations, and the mechanisms involved have been explored by various pharmacological strategies; 5-HT re-uptake inhibitors proved especially hazardous in combination. Interactions could, however, be avoided even with the 5-HT re-uptake inhibitors, by combination with relatively selective MAO A or B inhibitors, an approach with potential clinical value.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 4 , November 1983 , pp. 735 - 749
Copyright
Copyright © Cambridge University Press 1983

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