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Cognition in schizophrenia and schizo-affective disorder: impairments that are more similar than different

Published online by Cambridge University Press:  27 March 2013

A. Owoso ,
C. S. Carter ,
J. M. Gold ,
A. W. MacDonald III ,
J. D. Ragland ,
S. M. Silverstein ,
M. E. Strauss  and
D. M. Barch
A. Owoso*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
C. S. Carter
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
J. M. Gold
Affiliation:
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
A. W. MacDonald III
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
J. D. Ragland
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
S. M. Silverstein
Affiliation:
Division of Schizophrenia Research, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
M. E. Strauss
Affiliation:
Department of Psychology, Case Western Reserve University, Cleveland, OH, USA
D. M. Barch
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
*
*Address for correspondence: A. Owoso, M.D., Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8134, St Louis, MO 63110, USA. (Email: owosoa@psychiatry.wustl.edu)
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Abstract

Background

Cognition is increasingly being recognized as an important aspect of psychotic disorders and a key contributor to functional outcome. In the past, comparative studies have been performed in schizophrenia and schizo-affective disorder with regard to cognitive performance, but the results have been mixed and the cognitive measures used have not always assessed the cognitive deficits found to be specific to psychosis. A set of optimized cognitive paradigms designed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS) Consortium to assess deficits specific to schizophrenia was used to measure cognition in a large group of individuals with schizophrenia and schizo-affective disorder.

Method

A total of 519 participants (188 with schizophrenia, 63 with schizo-affective disorder and 268 controls) were administered three cognitive paradigms assessing the domains of goal maintenance in working memory, relational encoding and retrieval in episodic memory and visual integration.

Results

Across the three domains, the results showed no major quantitative differences between patient groups, with both groups uniformly performing worse than healthy subjects.

Conclusions

The findings of this study suggests that, with regard to deficits in cognition, considered a major aspect of psychotic disorder, schizophrenia and schizo-affective disorder do not demonstrate major significant distinctions. These results have important implications for our understanding of the nosological structure of major psychopathology, providing evidence consistent with the hypothesis that there is no natural distinction between cognitive functioning in schizophrenia and schizo-affective disorder.

Keywords

Cognitive performancediagnostic validitygoal maintenancememory encodingnosologypsychosisvisual processing
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 12 , December 2013 , pp. 2535 - 2545
Copyright
Copyright © Cambridge University Press 2013 

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Owoso Supplementary Material

Tables S1-S4

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Figure S1: Graph showing performance on Dot Probe Expectancy (DPX) task with number of errors for each of the four trial types (AX, AY, BX, BY). Error bars are standard errors.

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Figure S2: Bar graph illustrating performance in both encoding conditions of the item recognition portion of the Relational and Item Specific Encoding (RISE) task. Asterisk (*) significances are across participant groups while arrowhead (^) significances are within groups.

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Figure S3: Graph of mean accuracy scores across different jitter degree conditions of the Jittered Orientation Visual Integration (JOVI) task. Error bars are standard errors.

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