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Cortical morphology and early adverse birth events in men with first-episode psychosis

Published online by Cambridge University Press:  11 December 2014

G. N. Smith ,
A. E. Thornton ,
D. J. Lang ,
G. W. MacEwan ,
L. C. Kopala ,
W. Su  and
W. G. Honer
G. N. Smith*
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
A. E. Thornton
Affiliation:
Department of Psychology, Simon Fraser University, Burnaby, Canada
D. J. Lang
Affiliation:
Department of Radiology, University of British Columbia, Vancouver, Canada
G. W. MacEwan
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada South Fraser Early Psychosis Program, White Rock, Canada
L. C. Kopala
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada South Fraser Early Psychosis Program, White Rock, Canada
W. Su
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
W. G. Honer
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
*
* Address for correspondence: Dr G. N. Smith, Department of Psychiatry, University of British Columbia, Room A3-114, Translational Laboratory Building, 938 West 28th Ave, Vancouver, BC V5Z 4H4, Canada. (Email: geoffsm@mail.ubc.ca)
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Abstract

Background

Reduced cortical gray-matter volume is commonly observed in patients with psychosis. Cortical volume is a composite measure that includes surface area, thickness and gyrification. These three indices show distinct maturational patterns and may be differentially affected by early adverse events. The study goal was to determine the impact of two distinct obstetrical complications (OCs) on cortical morphology.

Method

A detailed birth history and MRI scans were obtained for 36 patients with first-episode psychosis and 16 healthy volunteers.

Results

Perinatal hypoxia and slow fetal growth were associated with cortical volume (Cohen's d = 0.76 and d = 0.89, respectively) in patients. However, the pattern of associations differed across the three components of cortical volume. Both hypoxia and fetal growth were associated with cortical surface area (d = 0.88 and d = 0.72, respectively), neither of these two OCs was related to cortical thickness, and hypoxia but not fetal growth was associated with gyrification (d = 0.85). No significant associations were found within the control sample.

Conclusions

Cortical dysmorphology was associated with OCs. The use of a global measure of cortical morphology or a global measure of OCs obscured important relationships between these measures. Gyrification is complete before 2 years and its strong relationship with hypoxia suggests an early disruption to brain development. Cortical thickness matures later and, consistent with previous research, we found no association between thickness and OCs. Finally, cortical surface area is largely complete by puberty and the present results suggest that events during childhood do not fully compensate for the effects of early disruptive events.

Keywords

Birthweightcortical gray matterimagingobstetric complicationsperinatal hypoxiapsychosis
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 9 , July 2015 , pp. 1825 - 1837
Copyright
Copyright © Cambridge University Press 2014 

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