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Disrupted rich club organization and structural brain connectome in unmedicated bipolar disorder

Published online by Cambridge University Press:  08 May 2018

Ying Wang Open the ORCID record for Ying Wang [Opens in a new window] ,
Feng Deng ,
Yanbin Jia ,
Junjing Wang ,
Shuming Zhong ,
Huiyuan Huang ,
Lixiang Chen ,
Guanmao Chen ,
Huiqing Hu  and
Li Huang
...Show all authors
Ying Wang*
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Feng Deng
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Yanbin Jia
Affiliation:
Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Junjing Wang
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Shuming Zhong
Affiliation:
Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Huiyuan Huang
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Lixiang Chen
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Guanmao Chen
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Huiqing Hu
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Li Huang
Affiliation:
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China
Ruiwang Huang*
Affiliation:
Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
*
Author for correspondence: Ying Wang, E-mail: johneil@vip.sina.com and Ruiwang Huang, E-mail: ruiwang.huang@gmail.com
Author for correspondence: Ying Wang, E-mail: johneil@vip.sina.com and Ruiwang Huang, E-mail: ruiwang.huang@gmail.com
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Abstract

Background

Bipolar disorder (BD) has been associated with altered brain structural and functional connectivity. However, little is known regarding alterations of the structural brain connectome in BD. The present study aimed to use diffusion-tensor imaging (DTI) and graph theory approaches to investigate the rich club organization and white matter structural connectome in BD.

Methods

Forty-two patients with unmedicated BD depression and 59 age-, sex- and handedness-matched healthy control participants underwent DTI. The whole-brain structural connectome was constructed by a deterministic fiber tracking approach. Graph theory analysis was used to examine the group-specific global and nodal topological properties, and rich club organizations, and then nonparametric permutation tests were used for group comparisons of network parameters.

Results

Compared with healthy control participants, the patients with BD showed abnormal global properties, including increased characteristic path length, and decreased global efficiency and local efficiency. Locally, the patients with BD showed abnormal nodal parameters (nodal strength, nodal efficiency, and nodal betweenness) predominantly in the parietal, orbitofrontal, occipital, and cerebellar regions. Moreover, the patients with BD showed decreased rich club and feeder connectivity density.

Conclusions

Our results may reflect the disrupted white matter topological organization in the whole-brain, and abnormal regional connectivity supporting cognitive and affective functioning in depressed BD, which, in part, be due to impaired rich club connectivity.

Keywords

Bipolar disorderdiffusion-tensor imaginggraph theoryrich club
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 3 , February 2019 , pp. 510 - 518
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

These authors contributed equally to this work.

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