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Effects of carbamazepine on serum electrolytes in affectively ill patients

Published online by Cambridge University Press:  09 July 2009

Russell T. Joffe ,
Robert M. Post  and
Thomas W. Uhde
Russell T. Joffe
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Robert M. Post*
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Thomas W. Uhde
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
*
1 Address for correspondence: Dr Robert M. Post, Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N212, 9000 Rockville Pike, Bethesda, MD 20205, USA.
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Synopsis

The effects on serum electrolytes of carbamazepine, an acute and prophylactic treatment for manic-depressive illness, were assessed in subjects with primary affective disorder. Carbamazepine caused statistically significant, but clinically insubstantial, reductions in serum sodium and calcium, but not in the other electrolytes measured. Decreases in serum sodium and calcium were not related to carbamazepine dose, blood levels, or the degree of clinical improvement. The theoretical implications of these findings are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 2 , May 1986 , pp. 331 - 335
Copyright
Copyright © Cambridge University Press 1986

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References

Ashton, M. G., Ball, F. G., Thomas, T. H. & Lee, M. R. (1977). Water intoxication associated with carbamazepine treatment. British Medical Journal i, 1134–1135.CrossRefGoogle Scholar
Berrettini, W. H., Post, R. M., Worthington, E. K. & Casper, J. B. (1982). Human platelet vasopressin receptors. Life Sciences 30, 425–432.CrossRefGoogle ScholarPubMed
Bunney, W. E. Jr & Hamburg, D. A. (1963). Methods for reliable longitudinal observation of behaviour. Archives of General Psychiatry 9, 280–294.CrossRefGoogle Scholar
Carman, J. S., Wyatt, E. S., Smith, W., Post, R. M. & Ballenger, J. C. (1984) Calcium and calcitonin in bipolar affective disorder. In Neurobiology of Mood Disorders (ed. Post, R. M. and Ballenger, J. C.), pp. 340–355. Williams & Wilkins: Baltimore.Google Scholar
Coppen, A. (1965). Mineral metabolism in affective disorders. British Journal of Psychiatry 111, 1133–1142.CrossRefGoogle ScholarPubMed
Dalby, M. A. (1971). Antiepileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychomotor epilepsy. Epilepsia 12, 325–334.CrossRefGoogle ScholarPubMed
Ekbom, K. (1972). Carbamazepine in the treatment of tabetic lightening pain. Archives of General Psychiatry 26, 374–378.Google Scholar
Gold, P. W., Robertson, G. L., Ballenger, J. C., Kaye, W., Chen, J., Rubinow, D. R., Goodwin, F. K. & Post, R. M. (1983). Carbamazepine diminishes the sensitivity of the plasma arginine vasopressin response to osmotic stimulation. Journal of Clinical Endocrinology and Metabolism 57, 952–957.CrossRefGoogle ScholarPubMed
Hahn, T. J. (1976). Bone complications of anticonvulsants. Drugs 12, 201–211.CrossRefGoogle ScholarPubMed
Helin, I., Nilsson, K. O., Bjeirre, I. & Vegfors, P. (1977). Serum sodium and osmolarity during carbamazepine treatment in children. British Medical Journal ii, 558.CrossRefGoogle Scholar
Henry, D. A., Lawson, D. H., Reavey, P. & Renfrew, J. (1977). Hyponatremia during carbamazepine treatment. British Medical Journal i, 83–84.CrossRefGoogle Scholar
Hoikka, V., Alhava, E. M., Karjalainen, P., Keranen, T. & Savolainen, K. (1983). Carbamazepine and bone mineral metabolism. Calcified Tissue International 35, Suppl, A46.Google Scholar
Hoikka, V., Alhava, E. M., Karjalainen, P., Keranen, T., Savolainen, K., Kiekkinen, P. & Korhonen, R. (1984). Carbamazepine and bone mineral metabolism. Acta Neurologica Scandinavica 69, 77–80.Google Scholar
Kay, D. S. G., Naylor, G. J., Smith, A. H. W. & Greenwood, C. (1984). The therapeutic effect of ascorbic acid and EDTA in manic-depressive psychosis: double-blind comparison with standard treatments. Psychological Medicine 14, 533–539.CrossRefGoogle ScholarPubMed
Kimura, T., Matsui, K., Sato, T. & Yoshinaga, K. (1974). Mechanism of carbamazepine (Tegretol)-induced antidiuresis: evidence for release of antidiuretic hormone and impaired excretion of a water load. Journal of Clinical Endocrinology and Metabolism 38, 356–362.CrossRefGoogle ScholarPubMed
Kondo, K., Igarashi, Y., Hara, R. & Noguchi, T. (1982). Levels of serum enzymes, calcium and inorganic phosphorus in epileptic patients treated with antiepileptic drugs. Folia Psychiatrica et Neurologica Japonica 36, 347–348.Google Scholar
Meinders, A. E., Cejka, V. & Robertson, G. L. (1974). The antidiuretic action of carbamazepine in man. Clinical Science and Molecular Medicine 47, 289–296.Google ScholarPubMed
Mosekilde, L. & Melsen, F. (1976). Anticonvulsant osteomalacia determined by quantitative analysis of bone changes. Acta Medica Scandinavica 199, 349–355.CrossRefGoogle ScholarPubMed
Naylor, G. J., Smith, A. H. W., Dick, E. G., Dick, D. A. T., McHarg, A. & Chambers, C. A. (1980). Erythrocyte membrane cation carrier in manic depressive psychosis. Psychological Medicine 10, 521–525.CrossRefGoogle ScholarPubMed
Nielsen, H. E., Melsen, F., Lund, B., Lund, B., Sorensen, O. H. & Mosekilde, L. (1983). Bone histomorphometry, vitamin D metabolites and calcium-phosphate metabolism in anticonvulsant treatment with carbamazepine. Calcified Tissue International 35, Suppl. A58.Google Scholar
O'Hare, J. A., Duggan, B., O'Driscoll, D. & Callaghan, N. (1980). Biochemical evidence for osteomalacia with carbamazepine theraphy. Acta Neurologica Scandinavica 72, 282–286.Google Scholar
Perucca, E., Garratt, A., Hebdige, J. & Richens, A. (1978). Water intoxication in epileptic patients receiving carbamazepine. Journal of Neurology, Neurosurgery and Psychiatry 41, 713–718.CrossRefGoogle ScholarPubMed
Porter, R. J. & Penry, J. K. (1978). Efficacy and choice of antiepileptic drugs. In Advances in Epileptology, 1977: Psychology, Pharmacotherapy and New Diagnostic Approaches (ed. Meinardi, H. and Rowan, A. J.), pp. 220–223. Swets & Zeitlinger: Amsterdam.Google Scholar
Post, R. M. & Uhde, T W. (1985). Carbamazepine in bipolar illness. Psychopharmacology Bulletin 21, 10–17.Google ScholarPubMed
Post, R. M., Ballenger, J. C., Uhde, T. W. & Bunney, W. E. Jr (1984). Efficacy of carbamazepine in manic-depressive illness: implications for underlying mechanisms. In Neurobiology of Mood Disorders (ed. Post, R. M. and Ballenger, J. C.), pp. 777–816. Williams & Wilkins: Baltimore.Google Scholar
Robinson, P. B., Harris, M., Harvey, W. & Papadogeorgakis, N. (1982). Reduced bone growth in rats treated with anticonvulsant drugs: a type II pseudohypoparathyroidism. Metabolic Bone Disease and Related Research 4, 269–275.CrossRefGoogle ScholarPubMed
Smith, N. J., Espir, M. L. E. & Baylas, P. H. (1977). Raised plasma arginine vasopressin. British Medical Journal iii, 804.CrossRefGoogle Scholar
Sordillo, P. (1978). Carbamazepine induced syndrome of inappropriate antidiuretic hormone secretion: reversal by concomitant phenytoin therapy. Archives of International Medicine 138, 299–302.CrossRefGoogle ScholarPubMed
Stephens, W. P., Espir, M. L., Tattersall, R. B., Quinn, N. P., Gladwell, S. R. F., Galbraith, A. W. & Reynolds, E. H. (1977). Water intoxication due to carbamazepine. British Medical Journal i, 754–755.CrossRefGoogle Scholar
Stephens, W. P., Coe, J. Y. & Baylis, P. H. (1978). Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine. British Medical Journal i, 1445–1447.CrossRefGoogle Scholar
Tjellesen, L. & Christiansen, C. (1983). Calcium metabolism in epileptic patients treated with carbamazepine. Calcium Tissue International 35, Suppl. A62.Google Scholar
Tjellesen, L., Gotfredsen, A. & Christiansen, C. (1983). Effect of vitamin D2 and D3 on bone mineral content in carbamazepine treated epileptic patients. Acta Neurologica Scandinavica 68, 424–428.CrossRefGoogle Scholar
Uhde, T. W. & Post, R. M. (1983). Effects of carbamazepine on serum electrolytes: clinical and theoretical implications. Journal of Clinical Psychopharmacology 3, 103–106.CrossRefGoogle ScholarPubMed
Wales, J. K. (1975). Treatment of diabetes insipidus with carbamazepine. Lancet i, 948–951.CrossRefGoogle Scholar