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Effects of depression co-morbidity and treatment on quality of life in patients with acute coronary syndrome: the Korean depression in ACS (K-DEPACS) and the escitalopram for depression in ACS (EsDEPACS) study

Published online by Cambridge University Press:  21 November 2014

J.-M. Kim ,
R. Stewart ,
K.-Y. Bae ,
H.-J. Kang ,
S.-W. Kim ,
I.-S. Shin ,
Y. J. Hong ,
Y. Ahn ,
M. H. Jeong  and
J.-S. Yoon
J.-M. Kim*
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
R. Stewart
Affiliation:
Institute of Psychiatry, King's College London, London, UK
K.-Y. Bae
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
H.-J. Kang
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
S.-W. Kim
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
I.-S. Shin
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
Y. J. Hong
Affiliation:
Department of Cardiology, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
Y. Ahn
Affiliation:
Department of Cardiology, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
M. H. Jeong
Affiliation:
Department of Cardiology, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
J.-S. Yoon
Affiliation:
Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea
*
* Address for correspondence: J.-M. Kim, M.D., Ph.D., Department of Psychiatry, Chonnam National University Medical School, 160 Baekseoro, Dong-gu, Gwangju, 501–746, Republic of Korea. (Email: jmkim@chonnam.ac.kr)
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Abstract

Background

Depression is common after acute coronary syndrome (ACS) with adverse effects on prognosis. There is little evidence on whether depression treatment improves quality of life (QoL) in ACS patients. The aim of this study was to investigate the effects of co-morbid depression and its treatment on QoL in ACS.

Method

In total, 1152 patients were recruited at baseline, 2–14 weeks after a confirmed ACS episode, and 828 were followed 1 year thereafter. Of 446 baseline participants with co-morbid depressive disorders, 300 were randomized to a 24-week double blind trial of escitalopram or placebo, while the remaining 146 received medical treatment only (MTO). QoL was measured by the World Health Organization Quality of Life –Abbreviated form (WHOQOL-BREF).

Results

At baseline, QoL was significantly lower in patients with co-morbid depressive disorder than those without. QoL improvement was significantly greater in those receiving escitalopram than those receiving placebo over the 24-week treatment period. In the 1-year follow-up, the better outcomes associated with escitalopram remained evident against both placebo and MTO.

Conclusions

Depression was significantly associated with worse QoL even in patients with recently developed ACS. Depression treatment was associated with QoL improvement in ACS patients in the 24-week treatment period, the effects of which extended to 1 year.

Keywords

Acute coronary syndromedepressionlongitudinal studyquality of liferandomized controlled trial
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 8 , June 2015 , pp. 1641 - 1652
Copyright
Copyright © Cambridge University Press 2014 

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References

Anderson, JL, Adams, CD, Antman, EM, Bridges, CR, Califf, RM, Casey, DE Jr., Chavey, WE II, Fesmire, FM, Hochman, JS, Levin, TN, Lincoff, AM, Peterson, ED, Theroux, P, Wenger, NK, Wright, RS, Jneid, H, Ettinger, SM, Ganiats, TG, Philippides, GJ, Jacobs, AK, Halperin, JL, Albert, NM, Creager, MA, DeMets, D, Guyton, RA, Kushner, FG, Ohman, EM, Stevenson, W, Yancy, CW (2013). 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable Angina/Non.s.T-Elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Journal of the American College of Cardiology 61, e179–e347.Google Scholar
APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Press Inc: Washington, DC.Google Scholar
Bambauer, KZ, Aupont, O, Stone, PH, Locke, SE, Mullan, MG, Colagiovanni, J, McLaughlin, TJ (2005). The effect of a telephone counseling intervention on self-rated health of cardiac patients. Psychosomatic Medicine 67, 539–545.Google Scholar
Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.Google Scholar
Beck, CA, Joseph, L, Belisle, P, Pilote, L, QOLAMI Investigators (Quality of life in acute myocardial infarction) (2001). Predictors of quality of life 6 months and 1 year after acute myocardial infarction. American Heart Journal 142, 271–279.CrossRefGoogle ScholarPubMed
Bush, DE, Ziegelstein, RC, Tayback, M, Richter, D, Stevens, S, Zahalsky, H, Fauerbach, JA (2001). Even minimal symptoms of depression increase mortality risk after acute myocardial infarction. American Journal of Cardiology 88, 337–341.CrossRefGoogle ScholarPubMed
Catipović-Veselica, K, Galić, A, Jelić, K, Baraban-Glavas, V, Sarić, S, Prlić, N, Catipović, B (2007). Relation between major and minor depression and heart rate, heart-rate variability, and clinical characteristics of patients with acute coronary syndrome. Psychological Reports 100, 1245–1254.Google Scholar
De Jonge, P, Spijkerman, TA, van den Brink, RH, Ormel, J (2006). Depression following myocardial infarction is a risk factor for declined health related quality of life and increased disability and cardiac complaints at 12 months. Heart 92, 32–39.Google Scholar
Dickens, C, Cherrington, A, McGowan, L (2012). Depression and health-related quality of life in people with coronary heart disease: a systematic review. European Journal of Cardiovascular Nursing 11, 265–275.Google Scholar
Dickens, CM, McGowan, L, Percival, C, Tomenson, B, Cotter, L, Heagerty, A, Creed, FH (2006). Contribution of depression and anxiety to impaired health-related quality of life following first myocardial infarction. British Journal of Psychiatry 189, 367–372.Google Scholar
Fournier, JC, DeRubeis, RJ, Hollon, SD, Dimidjian, S, Amsterdam, JD, Shelton, RC, Fawcett, J (2010). Antidepressant drug effects and depression severity: a patient-level meta-analysis. Journal of the American Medical Association 303, 47–53.Google Scholar
Glassman, AH, O'Connor, CM, Califf, RM, Swedberg, K, Schwartz, P, Bigger, JT Jr., Krishnan, KR, van Zyl, LT, Swenson, JR, Finkel, MS, Landau, C, Shapiro, PA, Pepine, CJ, Mardekian, J, Harrison, WM, Barton, D, Mclvor, M; Sertraline Antidepressant Heart Attack Randomized Trial (SADHEART) Group (2002). Sertraline treatment of major depression in patients with acute MI or unstable angina. Journal of the American Medical Association 288, 701–709.CrossRefGoogle ScholarPubMed
Hamilton, M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56–62.Google Scholar
Hong, YJ, Jeong, MH, Ahn, Y, Kang, JC (2013). The efficacy and safety of drug-eluting stents in patients with acute myocardial infarction: results from Korea Acute Myocardial Infarction (KAMIR). International Journal of Cardiology 163, 1–4.Google Scholar
Huffman, JC, Mastromauro, CA, Beach, SR, Celano, CM, DuBois, CM, Healy, BC, Suarez, L, Rollman, BL, Januzzi, JL (2014). Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial. Journal of the American Medical Association Internal Medicine 174, 927–935.Google Scholar
Jiang, W, Velazquez, EJ, Kuchibhatla, M, Samad, Z, Boyle, SH, Kuhn, C, Becker, RC, Ortel, TL, Williams, RB, Rogers, JG, O'Connor, C (2013). Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial. Journal of the American Medical Association 309, 2139–2149.Google Scholar
Killip, T, Kimball, JT (1967). Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. American Journal of Cardiology 20, 457–464.CrossRefGoogle Scholar
Kim, H, Lim, SW, Kim, S, Kim, JW, Chang, YH, Carroll, BJ, Kim, DK (2006). Monoamine transporter gene polymorphism and antidepressant response in Koreans with late-life depression. Journal of the American Medical Association 296, 1609–1618.Google Scholar
Kim, J-M, Bae, K-Y, Jung, B-O, Kang, H-J, Kim, S-Y, Kim, S-W, Shin, I-S, Hong, YJ, Kim, JH, Shin, H-Y, Ahn, Y, Kim, J-K, Jeong, MH, Yoon, J-S (2014b). Escitalopram treatment for depressive patients with acute coronary syndrome: a 24 week double-blind placebo-controlled trial. Journal of Clinical Psychiatry Published online: 14 10 2014 . doi:10.4088/JCP.14m09281.14.Google Scholar
Kim, JM, Bae, KY, Kang, HJ, Kim, SW, Shin, IS, Hong, YJ, Kim, JH, Shin, HY, Ahn, Y, Kim, JK, Jeong, MH, Yoon, JS (2014a). Design and methodology for the Korean observational and escitalopram treatment studies of depression in acute coronary syndrome: K-DEPACS and EsDEPACS. Psychiatry Investigation 11, 89–94.Google Scholar
Kim, JM, Kim, SW, Stewart, R, Kim, SY, Yoon, JS, Jung, SW, Lee, MS, Yim, HW, Jun, TY (2011). Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study. Human Psychopharmacology 26, 41–50.CrossRefGoogle Scholar
Lespérance, F, Frasure-Smith, N, Koszycki, D, Laliberté, MA, van Zyl, LT, Baker, B, Swenson, JR, Ghatavi, K, Abramson, BL, Dorian, P, Guertin, MC; CREATE Investigators (2007). Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. Journal of the American Medical Association 297, 367–379.CrossRefGoogle ScholarPubMed
Lesperance, F, Frasure-Smith, N, Talajic, M (1996). Major depression before and after myocardial infarction: its nature and consequences. Psychosomatic Medicine 58, 99–110.Google Scholar
Mendes de Leon, CF, Czajkowski, SM, Freedland, KE, Bang, H, Powell, LH, Wu, C, Burg, MM, DiLillo, V, Ironson, G, Krumholz, HM, Mitchell, P, Blumenthal, JA; ENRICHD investigators (2006). The effect of a psychosocial intervention and quality of life after acute myocardial infarction: the Enhancing Recovery in Coronary Heart Disease (ENRICHD) clinical trial. Journal of Cardiopulmonary Rehabilitation 26, 9–13.Google Scholar
Min, SK, Lee, CI, Kim, KI, Suh, SY, Kim, DK (2000). Development of Korean version of WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF). Journal of Korean Neuropsychiatric Association 39, 571–579.Google Scholar
Murray, CJL, Vos, T, Lazano, R, Naghavi, M, Flaxman, AD, Michaud, C, Ezzati, M, Shibuya, K, Salomon, JA, Abdalla, S, Aboyans, V, Abraham, J, Ackerman, I, Aggarwal, R, Ahn, SY, Ali, MK, Alvarado, M, Anderson, HR, Anderson, LM, Andrews, KG, Atkinson, C, Baddour, LM, Bahalim, AN, Barker-Collo, S, Barrero, LH, Bartels, DH, Basáñez, MG, Baxter, A, Bell, ML, Benjamin, EJ, Bennett, D, Bernabé, E, Bhalla, K, Bhandari, B, Bikbov, B, Bin, Abdulhak A, Birbeck, G, Black, JA, Blencowe, H, Blore, JD, Blyth, F, Bolliger, I, Bonaventure, A, Boufous, S, Bourne, R, Boussinesq, M, Braithwaite, T, Brayne, C, Bridgett, L, Brooker, S, Brooks, P, Brugha, TS, Bryan-Hancock, C, Bucello, C, Buchbinder, R, Buckle, G, Budke, CM, Burch, M, Burney, P, Burstein, R, Calabria, B, Campbell, B, Canter, CE, Carabin, H, Carapetis, J, Carmona, L, Cella, C, Charlson, F, Chen, H, Cheng, AT, Chou, D, Chugh, SS, Coffeng, LE, Colan, SD, Colquhoun, S, Colson, KE, Condon, J, Connor, MD, Cooper, LT, Corriere, M, Cortinovis, M, de Vaccaro, KC, Couser, W, Cowie, BC, Criqui, MH, Cross, M, Dabhadkar, KC, Dahiya, M, Dahodwala, N, Damsere-Derry, J, Danaei, G, Davis, A, De Leo, D, Degenhardt, L, Dellavalle, R, Delossantos, A, Denenberg, J, Derrett, S, Des Jarlais, DC, Dharmaratne, SD, Dherani, M, Diaz-Torne, C, Dolk, H, Dorsey, ER, Driscoll, T, Duber, H, Ebel, B, Edmond, K, Elbaz, A, Ali, SE, Erskine, H, Erwin, PJ, Espindola, P, Ewoigbokhan, SE, Farzadfar, F, Feigin, V, Felson, DT, Ferrari, A, Ferri, CP, Fèvre, EM, Finucane, MM, Flaxman, S, Flood, L, Foreman, K, Forouzanfar, MH, Fowkes, FG, Fransen, M, Freeman, MK, Gabbe, BJ, Gabriel, SE, Gakidou, E, Ganatra, HA, Garcia, B, Gaspari, F, Gillum, RF, Gmel, G, Gonzalez-Medina, D, Gosselin, R, Grainger, R, Grant, B, Groeger, J, Guillemin, F, Gunnell, D, Gupta, R, Haagsma, J, Hagan, H, Halasa, YA, Hall, W, Haring, D, Haro, JM, Harrison, JE, Havmoeller, R, Hay, RJ, Higashi, H, Hill, C, Hoen, B, Hoffman, H, Hotez, PJ, Hoy, D, Huang, JJ, Ibeanusi, SE, Jacobsen, KH, James, SL, Jarvis, D, Jasrasaria, R, Jayaraman, S, Johns, N, Jonas, JB, Karthikeyan, G, Kassebaum, N, Kawakami, N, Keren, A, Khoo, JP, King, CH, Knowlton, LM, Kobusingye, O, Koranteng, A, Krishnamurthi, R, Laden, F, Lalloo, R, Laslett, LL, Lathlean, T, Leasher, JL, Lee, YY, Leigh, J, Levinson, D, Lim, SS, Limb, E, Lin, JK, Lipnick, M, Lipshultz, SE, Liu, W, Loane, M, Ohno, SL, Lyons, R, Mabweijano, J, MacIntyre, MF, Malekzadeh, R, Mallinger, L, Manivannan, S, Marcenes, W, March, L, Margolis, DJ, Marks, GB, Marks, R, Matsumori, A, Matzopoulos, R, Mayosi, BM, McAnulty, JH, McDermott, MM, McGill, N, McGrath, J, Medina-Mora, ME, Meltzer, M, Mensah, GA, Merriman, TR, Meyer, AC, Miglioli, V, Miller, M, Miller, TR, Mitchell, PB, Mock, C, Mocumbi, AO, Moffitt, TE, Mokdad, AA, Monasta, L, Montico, M, Moradi-Lakeh, M, Moran, A, Morawska, L, Mori, R, Murdoch, ME, Mwaniki, MK, Naidoo, K, Nair, MN, Naldi, L, Narayan, KM, Nelson, PK, Nelson, RG, Nevitt, MC, Newton, CR, Nolte, S, Norman, P, Norman, R, O'Donnell, M, O'Hanlon, S, Olives, C, Omer, SB, Ortblad, K, Osborne, R, Ozgediz, D, Page, A, Pahari, B, Pandian, JD, Rivero, AP, Patten, SB, Pearce, N, Padilla, RP, Perez-Ruiz, F, Perico, N, Pesudovs, K, Phillips, D, Phillips, MR, Pierce, K, Pion, S, Polanczyk, GV, Polinder, S, Pope, CA 3rd, Popova, S, Porrini, E, Pourmalek, F, Prince, M, Pullan, RL, Ramaiah, KD, Ranganathan, D, Razavi, H, Regan, M, Rehm, JT, Rein, DB, Remuzzi, G, Richardson, K, Rivara, FP, Roberts, T, Robinson, C, De Leòn, FR, Ronfani, L, Room, R, Rosenfeld, LC, Rushton, L, Sacco, RL, Saha, S, Sampson, U, Sanchez-Riera, L, Sanman, E, Schwebel, DC, Scott, JG, Segui-Gomez, M, Shahraz, S, Shepard, DS, Shin, H, Shivakoti, R, Singh, D, Singh, GM, Singh, JA, Singleton, J, Sleet, DA, Sliwa, K, Smith, E, Smith, JL, Stapelberg, NJ, Steer, A, Steiner, T, Stolk, WA, Stovner, LJ, Sudfeld, C, Syed, S, Tamburlini, G, Tavakkoli, M, Taylor, HR, Taylor, JA, Taylor, WJ, Thomas, B, Thomson, WM, Thurston, GD, Tleyjeh, IM, Tonelli, M, Towbin, JA, Truelsen, T, Tsilimbaris, MK, Ubeda, C, Undurraga, EA, van der Werf, MJ, van Os, J, Vavilala, MS, Venketasubramanian, N, Wang, M, Wang, W, Watt, K, Weatherall, DJ, Weinstock, MA, Weintraub, R, Weisskopf, MG, Weissman, MM, White, RA, Whiteford, H, Wiebe, N, Wiersma, ST, Wilkinson, JD, Williams, HC, Williams, SR, Witt, E, Wolfe, F, Woolf, AD, Wulf, S, Yeh, PH, Zaidi, AK, Zheng, ZJ, Zonies, D, Lopez, AD, AlMazroa, MA, Memish, ZA, (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197–2223.Google Scholar
Norman, GR, Sloan, JA, Wyrwich, KW (2003). Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Medical Care 41, 582–592.Google Scholar
Parashar, S, Rumsfeld, JS, Spertus, JA, Reid, KJ, Wenger, NK, Krumholz, HM, Amin, A, Weintraub, WS, Lichtman, J, Dawood, N, Vaccarino, V (2006). Time course of depression and outcome of myocardial infarction. Archives of Internal Medicine 166, 2035–2043.Google Scholar
Rollman, BL, Belnap, BH, LeMenager, MS, Mazumdar, S, Houck, PR, Counihan, PJ, Kapoor, WN, Schulberg, HC, Reynolds, CF III (2009). Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. Journal of the American Medical Association 302, 2095–2103.CrossRefGoogle ScholarPubMed
Roose, SP, Laghrissi-Thode, F, Kennedy, JS, Nelson, JC, Bigger, JT Jr., Pollock, BG, Gaffney, A, Narayan, M, Finkel, MS, McCafferty, J, Gergel, I (1998). Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. Journal of the American Medical Association 279, 287–291.CrossRefGoogle ScholarPubMed
Rudisch, B, Nemeroff, CB (2003). Epidemiology of comorbid coronary artery disease and depression. Biological Psychiatry 54, 227–240.Google Scholar
Ruo, B, Rumsfeld, JS, Hlatky, MA, Liu, H, Browner, WS, Whooley, MA (2003). Depressive symptoms and health-related quality of life: the Heart and Soul Study. Journal of the American Medical Association 290, 215–222.Google Scholar
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC (1998). The mini-international neuropsychiatric interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 (Suppl.), 22–33.Google Scholar
Stafford, L, Berk, M, Reddy, P, Jackson, HJ (2007). Comorbid depression and health-related quality of life in patients with coronary artery disease. Journal of Psychosomatic Research 62, 401–410.Google Scholar
Stewart, JA, Deliyannides, DA, Hellerstein, DJ, McGrath, PJ, Stewart, JW (2012). Can people with nonsevere major depression benefit from antidepressant medication? Journal of Clinical Psychiatry 73, 518–525.Google Scholar
Strik, JJ, Honig, A, Lousberg, R, Lousberg, AH, Cheriex, EC, Tuynman-Qua, HG, Kuijpers, PM, Wellens, HJ, Van Praag, HM (2000). Efficacy and safety of fluoxetine in the treatment of patients with major depression after first myocardial infarction: findings from a double-blind, placebo-controlled trial. Psychosomatic Medicine 62, 783–789.Google Scholar
Sullivan, MD, LaCroix, AZ, Russo, JE, Walker, EA (2001). Depression and self-reported physical health in patients with coronary disease: mediating and moderating factors. Psychosomatic Medicine 63, 248–256.Google Scholar
Swenson, JR, O'Connor, CM, Barton, D, Van Zyl, LT, Swedberg, K, Forman, LM, Gaffney, M, Glassman, AH; Sertraline Antidepressant Heart Attack Randomized Trial (SADHART) Group (2003). Influence of depression and effect of treatment with sertraline on quality of life after hospitalization for acute coronary syndrome. American Journal of Cardiology 92, 1271–1276.Google Scholar
The WHOQOL Group (1998). Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychological Medicine 28, 551–558.Google Scholar
van Melle, JP, de Jonge, P, Honig, A, Schene, AH, Kuyper, AM, Crijns, HJ, Schins, A, Tulner, D, van den Berg, MP, Ormel, J; MIND-IT investigators (2007). Effects of antidepressant treatment following myocardial infarction. British Journal of Psychiatry 190, 460–466.Google Scholar
Von Korff, M, Katon, WJ, Lin, EH, Ciechanowski, P, Peterson, D, Ludman, EJ, Young, B, Rutter, CM (2011). Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial. British Medical Journal 343, d6612.Google Scholar
Zhang, X, Patel, A, Horibe, H, Wu, Z, Barzi, F, Rodgers, A, MacMahon, S, Woodward, M; Asia Pacific Cohort Studies Collaboration (2003). Cholesterol, coronary heart disease, and stroke in the Asia Pacific region. International Journal of Epidemiology 32, 563–572.Google Scholar