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Effects of major depression on the cognitive function of younger and older subjects

Published online by Cambridge University Press:  09 July 2009

A. F. Tarbuck*
Affiliation:
Department of Old Age Psychiatry, Fulbourn Hospital, Cambridge; Department of Psychiatry, University of Cambridge
E. S. Paykel
Affiliation:
Department of Old Age Psychiatry, Fulbourn Hospital, Cambridge; Department of Psychiatry, University of Cambridge
*
1Address for correspondence: Dr Andrew F. Tarbuck, Psychiatric Services for the Elderly, Fulbourn Hospital, Cambridge, CB1 5EF.

Synopsis

The effects of age and depression on cognitive function were investigated in two groups of in-patient major depressives aged under and over 60 years who were tested when depressed and after recovery. The majority of the tests showed impaired performance during depression with improvement after recovery, and also differences between the two age-groups in both the depressed and recovered phases. However, the older subjects were not more severely affected by depression than the younger subjects. The pattern of impairment associated with depression was different to that associated with older age: depression affected performance on more ‘complex tasks’, whereas age was associated particularly with slowing on timed tests. This study did not suggest that the impairment from baseline due to depression is greater in the elderly than in younger subjects.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1995

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References

Abas, M. A., Sahakian, B. J. & Levy, R. (1990). Neuropsychological deficits and CT scan changes in elderly depressives. Psychological Medicine 20, 507520.CrossRefGoogle ScholarPubMed
Alexopoulos, G. S. (1989). Late-life depression and neurological brain disease. International Journal of Geriatric Psychiatry 4, 187190.CrossRefGoogle Scholar
Alexopoulos, G. S., Young, R. C., Meyers, B. S., Abrams, R. C. & Shamoian, C. A. (1988). Late-onset depression. Psychiatric Clinics 11, 101115.Google ScholarPubMed
Benton, A. L. (1977). Interactive effects of age and brain disease on reaction time. Archives on Neurology 34, 369370.CrossRefGoogle ScholarPubMed
Bhaji, S. & Lader, M. (1977). The electroencephalographic and physiological effects of imipramine in depressed patients. European Journal of Clinical Pharmacology 112, 349359.CrossRefGoogle Scholar
Caine, E. D. (1981). Pseudodementia; current concepts and future directions. Archives of General Psychiatry 38, 13591364.CrossRefGoogle ScholarPubMed
Cockburn, J. & Smith, P. T. (1989). The Rivermead Behavioural Memory Test, Supplement 3: Elderly People. Thames Valley Test Company: Titchfield, Hants.Google Scholar
Coffey, C. E., Wilkinson, W. E., Weiner, R. D., Parashos, I. A., Djang, W. T. & Webb, M. C. (1993). Quantitative cerebral anatomy in depression; a controlled magnetic resonance imaging study. Archives of General Psychiatry 50, 716.CrossRefGoogle ScholarPubMed
Cohen, R. M., Weingartner, H., Smallberg, S. A., Pickar, D. & Murphy, D. L. (1982). Effort and cognition in depression. Archives of General Psychiatry 39, 593597.CrossRefGoogle ScholarPubMed
Cole, J. O. & Davis, J. M. (1975). Antidepressant drugs. In Comprehensive Textbook of Psychiatry, 2nd edn. (ed. Freedman, A. M., Kaplan, H. I. and Sadock, B. J.), pp. 19411956. Williams & Wilkins Company: Baltimore.Google Scholar
Collins, A. M. & Quillian, M. R. (1969). Retrieval time from semantic memory. Journal of Verbal Learning and Verbal Behaviour 8, 240247.CrossRefGoogle Scholar
Cummings, J., Benson, D. F. & LoVerme, S. (1980). Reversible dementia. Journal of the American Medical Association 243, 24342439.CrossRefGoogle ScholarPubMed
Davies, R. K., Tucker, G. J. & Harrow, M. (1971). Confusional episodes and antidepressant medication. American Journal of Psychiatry 128, 9599.CrossRefGoogle ScholarPubMed
Dolan, R. J., Calloway, S. P. & Mann, A. H. (1985). Cerebral ventricular size in depressed patients. Psychological Medicine 15, 873878.CrossRefGoogle Scholar
Dysken, M. W., Merry, W. & Davis, J. M. (1978). Anticholinergic psychosis. Psychiatry Annals 8, 452456.CrossRefGoogle Scholar
Feehan, M., Knight, R. G. & Partridge, F. M. (1991). Cognitive complaint and test performance in elderly patients suffering from depression or dementia. International Journal of Geriatric Psychiatry 6, 287293.CrossRefGoogle Scholar
Feinberg, T. & Goodman, B. (1984). Affective illness, dementia and pseudodementia. Journal of Clinical Psychiatry 45, 99103.Google ScholarPubMed
Folstein, M. G., Folstein, S. E. & McHugh, P. R. (1975). Minimental state. Psychiatry Research 12, 189198.CrossRefGoogle Scholar
Glass, R. M., Uhlenhuth, R. H., Hartel, F. W., Matuzas, W. & Fischman, M. W. (1981). Cognitive dysfunction and imipramine in out-patient depressives. Archives of General Psychiatry 38, 10481051.CrossRefGoogle Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 135, 7778.Google Scholar
Hart, R. P. & Kwentus, J. A. (1987). Psychomotor slowing and subcortical-type dysfunction in depression. Journal of Neurology, Neurosurgery and Psychiatry 50, 12631266.CrossRefGoogle ScholarPubMed
Hart, R. P., Kwentus, J. A., Taylor, J. R. & Hamer, R. M. (1988). Productive naming and memory in depression and Alzheimer's type dementia. Archives of Clinical neuropsychology 3, 313322.CrossRefGoogle ScholarPubMed
Huppert, F. A. (1987). Cognitive function. In Health and Lifestyle Survey; Preliminary Report of a Nationwide Survey of Physical and Mental Health, Attitudes and Lifestyle in a Random Sample of 9003 British Adults (ed. Cox, B. D.), pp. 4350. Health Promotion Research Trust: London.Google Scholar
Jacoby, R. J. & Levy, R. (1980). Computed tomography in the elderly; 3, affective disorder. British Journal of Psychiatry 136, 270275.CrossRefGoogle ScholarPubMed
Jansen, W. & Siegfried, K. (1984). Nomifensine in geriatric in-patients, a placebo-controlled study. Journal of Clinical Psychiatry 45, (sect. 2), 6367.Google Scholar
Kahn, R. L., Zarit, S. H., Hilbert, N. M. & Niederehe, G. (1975). Memory complaint in the aged. Archives of General Psychiatry 32, 15691573.CrossRefGoogle ScholarPubMed
Kellner, C. H., Rubinow, D. R. & Post, R. M. (1986). Cerebral ventricular size and cognitive impairment in depression. Journal of Affective Disorders 10, 215219.CrossRefGoogle ScholarPubMed
Kral, V. A. & Emery, V. B. (1989). Long-term follow-up of depressive pseudodementia of the aged. Canadian Journal of Psychiatry 34, 445446.CrossRefGoogle ScholarPubMed
Kramer, N. A. & Jarvik, L. (1979). Assessment of intellectual changes in the elderly. In Psychiatric Symptoms and Cognitive Loss in the Elderly (ed Raskin, A. and Jarvik, L.), pp. 221271. Hemisphere: Washington, DC.Google Scholar
Lamberty, G. J. & Bieliauskas, L. A. (1993). Distinguishing between depression and dementia in the elderly: a review of neuropsychological findings. Archives of Clinical Neuropsychology 8, 149170.CrossRefGoogle ScholarPubMed
Lezak, M. D. (1983). Neuropsychological Assessment. Oxford University Press: Oxford.Google Scholar
Lowenthal, M. F. & Berkman, P. L. (1967). Ageing and Mental Disorder in San Francisco. Jossey-Bass Inc.: San Francisco.Google Scholar
McAllister, T. W. (1983). Overview; pseudodementia. American Journal of Psychiatry, 140, 528533.Google ScholarPubMed
McNair, D. M. & Kahn, R. J. (1983). Self-assessment of cognitive deficits. In Assessment in Geriatric Psychopharmacology (ed. Crook, T., Ferris, S. and Bartus, R.), pp. 137143. Mark Powley Associates Inc.: Connecticut.Google Scholar
Marsden, C. D. & Harrison, M. J. G. (1972). Outcome of investigation of patients with presenile dementia. British Medical Journal 17, 249252.CrossRefGoogle Scholar
Miller, W. R. (1975). Psychological deficits in depression. Psychological Bulletin 82, 238260.CrossRefGoogle ScholarPubMed
Montgomery, S. A. & Åsberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382389.CrossRefGoogle ScholarPubMed
Nelson, H. E. (1982). The National Adult Reading Test Manual. NEFR Nelson: Windsor.Google Scholar
Niederehe, G. (1986). Depression and memory impairment in the aged. In Handbook for Clinical Memory Assessment in Older Adults (ed. Poon, L.), pp. 226237. American Psychological Association: Washington, DC.CrossRefGoogle Scholar
Norušis, M. (1988). Statistical Package for Social Sciences (SPSS/PC+). SPSS Inc.: Chicago.Google Scholar
Nott, P. N. & Fleminger, J. J. (1975). Presenile dementia, the difficulties of early diagnosis. Acta Psychiatrica Scandanavica 51, 210217.CrossRefGoogle ScholarPubMed
O'Connor, D. W., Pollit, P. A., Roth, M., Brook, C. P. B. & Reiss, B. B. (1990). Memory complaints and impairment in normal, depressed and demented elderly persons identified in a community survey. Archives of General Psychiatry 47, 224227.CrossRefGoogle Scholar
Paykel, E. S. (1985). Clinical interview for depression, development, reliability and validity. Journal of Affective Disorders 9, 8596.CrossRefGoogle ScholarPubMed
Pirozzolo, F. J., Mahurin, R. K., Loring, D. W., Appel, S. H. & Maletta, G. J. (1985). Choice reaction time modifiability in dementia and depression. International Journal of Neuroscience 26, 17.CrossRefGoogle ScholarPubMed
Plotkin, D. A., Mintz, J. & Jarvik, L. (1985). Subjective memory complaints in geriatric depression. American Journal of Psychiatry 142, 11031105.Google ScholarPubMed
Popkin, S. J., Gallagher, D., Thompson, L. W. & Moore, M. (1982). Memory complaint and performance in normal and depressed older adults. Experimental Ageing Research 8, 141145.CrossRefGoogle ScholarPubMed
Rabins, P. V., Merchant, A. & Nedstadt, G. (1984). Criteria for diagnosing reversible dementia caused by depression; validation of a 2 year follow-up. British Journal of Psychiatry 144, 488492.CrossRefGoogle Scholar
Raskin, A. (1986). Partialing out the effects of depression and age on cognitive functions; experimental data and methodologic issues. In Handbook for Clinical Memory Assessment of Older Adults (ed. Poon, L.), pp. 244256. American Psychological Association: Washington, DC.CrossRefGoogle Scholar
Raskin, A., Friedman, A. S. & DiMascio, A. (1982). Cognitive and performance deficits in depression. Psychopharmacology Bulletin 18, 196202.Google ScholarPubMed
Ron, M. A., Toone, B. K., Garralda, M. E. & Lishman, W. A. (1979). Diagnostic accuracy in presenile dementia. British Journal of Psychiatry 134, 161168.CrossRefGoogle ScholarPubMed
Roy-Byrne, P. P., Weingartner, H., Bierer, L. M. & Post, R. M. (1986). Effortful and automatic cognitive processes in depression. Archives of General Psychiatry 43, 265267.CrossRefGoogle ScholarPubMed
Savard, R. J., Rey, A. C. & Post, R. M. (1980). Halstead-Reitan category test in bipolar and unipolar affective disorders; relationships to age and phase of illness. Journal of Nervous and Mental Disease 168, 297304.CrossRefGoogle ScholarPubMed
Siegfried, K. (1985). Cognitive symptoms in late life depression and their treatment. Journal of Affective Disorders supplement 1, S33S40.CrossRefGoogle Scholar
Spring, B., Gelenberg, A. J., Garvin, R. & Thompson, S. (1992). Amitriptyline, clovoxamine and cognitive function; a placebo-controlled comparison in depressed out-patients. Psychopharmacology; Berlin 108, 327332.CrossRefGoogle Scholar
Steingart, A. & Hermann, N. (1991). Major depressive disorder in the elderly; the relationship between age of onset and cognitive impairment. International Journal of Geriatric Psychiatry 6, 593598.CrossRefGoogle Scholar
Sternberg, D. E. & Jarvik, M. E. (1976). Memory functions in depression. Archives of General Psychiatry 33, 219224.CrossRefGoogle ScholarPubMed
Tombaugh, T. N. & McIntyre, N. J. (1992). The mini-mental state examination: a comprehensive review. Journal of the American Geriatrics Society 40, 922935.CrossRefGoogle ScholarPubMed
Weckowicz, T. E., Nutter, R. W. & Cruise, D. G. (1972). Speed in test performance in relation to depressive illness and age. Journal of the Canadian Psychiatric Association 17, supplement 288, 241250.CrossRefGoogle ScholarPubMed
Weingartner, H. (1986). Automatic and effort-demanding cognitive processes in depression In Handbook for Clinical Memory Assessment of Older Adults (ed. Poon, L.), pp. 218225. American Psychological Association: Washington, DC.CrossRefGoogle Scholar
Weingartner, H. & Silberman, E. (1984). Cognitive changes in depression. In Frontiers of Clinical Neuroscience; Neurobiology of Mood Disorders Volume 1 (ed. Post, R. M. and Ballinger, J. C.), pp. 121135. Williams and Wilkins: Baltimore, MD.Google Scholar
Whitehead, A. (1974). Verbal learning and memory in elderly depressives. British Journal of Psychiatry 123, 203208.CrossRefGoogle Scholar
Wilson, B. A., Cockburn, J. & Baddeley, A. D. (1985). The Rivermead Behavioural Memory Test. Thames Valley Test Company: Titchfield, Hants.Google Scholar
Wilson, B. A., Cockburn, J. & Halligan, P. (1987). Behavioural Inattention Test. Thames Valley Test Company: Titchfield, Hants.Google Scholar
Zubenko, G. S., Sullivan, P., Nelson, J. P., Belle, S. H., Hutt, F. J. & Wolf, G. L. (1990). Brain imaging abnormalities in mental disorders of late life. Archives of Neurology 47, 11071111.CrossRefGoogle ScholarPubMed