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Hypogyrification in obsessive-compulsive disorder

Published online by Cambridge University Press:  12 December 2016

O. G. Rus ,
T. J. Reess ,
G. Wagner ,
M. Zaudig ,
C. Zimmer  and
K. Koch
O. G. Rus*
Affiliation:
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany
T. J. Reess
Affiliation:
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany
G. Wagner
Affiliation:
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
M. Zaudig
Affiliation:
Windach Institute and Hospital of Neurobehavioural Research and Therapy (WINTR), Windach, Germany
C. Zimmer
Affiliation:
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany
K. Koch
Affiliation:
Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany
*
*Address for correspondence: Dipl.-Psych. O. G. Rus, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany. (Email: georgiana.rus@tum.de)
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Abstract

Background

Previous studies hypothesized that neurodevelopmental risk factors may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Cortical folding has been shown to be a reliable indicator for normal and altered neurodevelopment, but in OCD it has barely been investigated up to now. The present study investigates whether alterations in gyrification are detectable in OCD and, if so, how these are associated with clinical characteristics.

Method

We compared the local Gyrification Index (lGI) between 75 OCD patients and 75 matched healthy subjects across the whole brain. In addition, for those regions exhibiting an altered lGI in patients we explored a potential relationship to symptom severity, age of onset, and influence of medication.

Results

OCD patients had a significantly decreased lGI in right parietal, precentral but also insula, temporal, pars triangularis and rostral middle frontal regions compared to healthy subjects. A positive association with age of onset was found but no association with symptom severity. There was no effect of co-morbidity or medication.

Conclusions

The reduced gyrification found in OCD confirms previous findings in other psychiatric disorders and suggests that alterations may already occur during early stages of brain development. Our findings support the idea that altered cortical folding might represent a trait characteristic of the disorder although longitudinal studies are needed to clarify the trajectory of this morphological measure in OCD.

Keywords

Cortical foldingfreesurfergyrification OCDlocal gyrification indexobsessive compulsive disorder
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 6 , April 2017 , pp. 1053 - 1061
Copyright
Copyright © Cambridge University Press 2016 

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