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Improvement in central monoamine metabolism in adult coeliac patients starting a gluten-free diet

Published online by Cambridge University Press:  09 July 2009

Claes Hallert  and
Göran Sedvall
Claes Hallert*
Affiliation:
Department of Internal Medicine, Central Hospital, Växjö, and the Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden
Göran Sedvall
Affiliation:
Department of Internal Medicine, Central Hospital, Växjö, and the Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden
*
1Address for correspondence: Dr Claes Hallert, Department of Internal Medicine, Central Hospital, S-351 85 Växjö, Sweden.
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Synopsis

Adult coeliac patients taking a gluten-free diet for one year showed an increase of 33% in the concentrations in CSF of major monoamine metabolites (5-HIAA, HVA and MOPEG). Tryptophan in CSF rose by 10%. There was concomitant morphological improvement in the jejunal mucosa, and the results would seem to indicate that the reduced central monoamine metabolism in untreated adult coeliacs is not primarily genetically determined but is probably related to the poor intestinal absorption.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 2 , May 1983 , pp. 267 - 271
Copyright
Copyright © Cambridge University Press 1983

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